TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.C.97.1.1









Pleurotolysin A/B pore-forming toxin. Pleurotolysin A (PlyA; also called ostreolysin A, OlyA) binds first in a sphingomyelin-dependent process; Pleurotolysin B (PlyS) binds to A in the membrane and inserts (Kondos et al., 2011).  The binary cytolytic pore-forming complex forms non-selective ion conducting pores of variable size (Schlumberger et al. 2013) to promote fruiting (Ota et al. 2014). Conformational changes accompanying pore formation have been reported (Lukoyanova et al. 2015).   In these systems, the aegerolysin-like proteins provide the membrane cholesterol/sphingomyelin selectivity and recruit oligomerised pleurotolysin B molecules, to create a membrane-inserted pore complex. The resulting protein structure has been imaged with electron microscopy, and it has a 13-meric rosette-like structure, with a central lumen that is ~4-5 nm in diameter. The opened transmembrane pore is non-selectively permeable for ions and smaller neutral solutes, and is a cause of cytolysis of a colloid-osmotic type (Ota et al. 2014).

Eukaryota
Fungi
Pleurotolysin A/B of Pleurotus ostreatus
Pleurotolysin A (138aas) (Q8X1M9)
Pleurotolysin B precursor (Q5W9E8)
*1.C.97.1.2









Pleurotolysin B

Eukaryota
Fungi

*1.C.97.1.3









MACPF protein homologue of Erylysin B

Eukaryota
Dictyosteliida
MACPF protein of Dictyostelium discoideum (Q54I05)
*1.C.97.1.4









Hypothetical protein homologous to Erylysin B of 924aas with a MACPF domain.

Eukaryota
Fungi
Hypothetical protein of Chaetomium globosum (Q2GRU1)
*1.C.97.1.5









Uncharacterized protein of 557 aas

Eukaryota
Fungi
UP of Aspergillus oryzae
*1.C.97.1.6









Uncharacterized protein homologous to Erylysin B (892aas) Residues 85-337aas of Erylysin B align with residues 242-477 of the Chlorobium sequence.

Bacteria
Bacteroidetes/Chlorobi group
Hypothetical protein of Chlorobium limicola (B3EDT0)
*1.C.97.1.7









Uncharacterized protein of 1165 aas

Bacteria
Proteobacteria
UP of Tistrella mobilis
*1.C.97.1.8









Uncharacterized protein of 800 aas with an N-terminal 280 aa soluble PQ-rich domain that shows similarity with TC# 1.B.27.1.9 and a C-terminal domain rich in predicted β-structure that shows similarity to Pleurotolysin snf its homologues.

Eukaryota
Fungi
UP of Hypocrea virens (Gliocladium virens) (Trichoderma virens)
*1.C.97.1.9









Uncharacterized protein of 668 aas

Eukaryota
Fungi
UP of Piriformospora indica
*1.C.97.2.1









Putative hemolysin of 224 aas

Eukaryota
Fungi
Putative hemolysin of Ajellomyces dermatitidis (Blastomyces dermatitidis)
*1.C.97.2.2









Uncharacterized protein of 282 aas

Eukaryota
Fungi
UP of Coccidioides posadasii (Valley fever fungus)
*1.C.97.2.3









Uncharacterized protein of 244 aas

Eukaryota
Fungi
UP of Ajellomyces capsulatus (Darling's disease fungus) (Histoplasma capsulatum)
*1.C.97.2.4









Uncharacterized protein of 190 aas

Eukaryota
Fungi
UP of Cyphellophora europaea
*1.C.97.3.1









Hemolysin of 198 aas

Eukaryota
Fungi
Hemolysin of Neurospora crassa
*1.C.97.3.2









Pore-forming ostreolysin (Berne et al., 2005). 97% identical to Erylysin A (1.C.97.1.2).

Eukaryota
Fungi
Ostreolysin of Pleurotus osteatus (P83467)
*1.C.97.3.3









Aegerolysin (135aas) (Homologous to Pleurotolysin A).  Aegerolysin-like proteins provide the membrane cholesterol/sphingomyelin selectivity and recruit oligomerized pleurotolysin B molecules to create a membrane-inserted pore complex (Ota et al. 2014).

Bacteria
Bacteroidetes/Chlorobi group
Aegerolysin of Spirosoma linguale (D2QTE8)
*1.C.97.3.4









Aegerolysin (121aas) (Homologous to Pleurotolysin A)

Bacteria
Proteobacteria
Aegerolysin of Pseudomonas aeruginosa (A6UXQ8)
*1.C.97.3.5









Putative hemolysin of 140 aas

Eukaryota
Fungi
Hemolysin of Penicillium oxalicum (Penicillium decumbens)
*1.C.97.3.6









Putative hemolysin of  199 aas

Eukaryota
Fungi
Putative hemolysin of Ajellomyces capsulatus (Darling's disease fungus) (Histoplasma capsulatum)
*1.C.97.3.7









Putative hemolysin of 222 aas

Viruses
Ascoviridae
Putative hemolysin of Trichoplusia ni ascovirus 2c
*1.C.97.3.8









Putative hemolysin of 204 aas

Eukaryota
Viridiplantae
Putative hemolysin of Selaginella moellendorffii (Spikemoss)