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1.E.1.1.1
Lysis protein S; also called ''pinholin''; forms small heptameric pores that depolarize the membrane (Park et al., 2007; Pang et al., 2009).  This holin is of topological Class II, forming 2 TMSs, with the N- and C-termini inside (Park et al. 2006).

Accession Number:P27360
Protein Name:VLYS aka S
Length:71
Molecular Weight:7893.00
Species:Bacteriophage P21 (Bacteriophage 21) [10711]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate endolysin, small molecules

Cross database links:

Pfam: PF04971   

Gene Ontology

GO:0016998 P:cell wall macromolecule catabolic process
GO:0019835 P:cytolysis

References (1)

[1] “Dual start motif in two lambdoid S genes unrelated to lambda S.”  Bonovich M.T.et.al.   2019562

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKSMDKISTG IAYGTSAGSA GYWFLQWLDQ VSPSQWAAIG VLGSLVLGFL TYLTNLYFKI 
61:	REDRRKAARG E