1.E.1.1.3
Holin of 68 aas and 1 TMS. Deleting the lysis module, encoding the holin, lysin and two spanins, increases outer membrane vesicle (OMV) production, suggesting that
during evolution this operon has been domesticated to regulate
vesiculation, possibly through the elimination of non-recyclable
peptidoglycan fragments (Pasqua et al. 2021). The expression of the lysis
module is negatively regulated by environmental stress stimuli as high
osmolarity, low pH and low temperature (Pasqua et al. 2021).
|
| Accession Number: | O48430 |
|---|
| Protein Name: | Putative holin protein S |
|---|
| Length: | 68 |
|---|
| Molecular Weight: | 7626.00 |
|---|
| Species: | Bacteriophage H19B [69932] |
|---|
| Number of TMSs: | 1 |
|---|
| Location1 / Topology2 / Orientation3: |
Secreted1 |
|---|
| Substrate |
molecule |
|---|
| Pfam: |
PF04971
|
|---|
[1] “Functional and genetic analysis of regulatory regions of coliphage H-19B: location of shiga-like toxin and lysis genes suggest a role for phage functions in toxin release.” Neely M.N. et.al. 9680214
[2] “Arrangement and functional identification of genes in the regulatory region of lambdoid phage H-19B, a carrier of a shiga-like toxin.” Neely M.N. et.al. 9858702
|
1: MEKITTGVSY TTSAVGTGYW LLQLLDKVSP SQWVAIGVLG SLLFGLLTYL TNLYFKIRED
61: RRKAVRGE