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1.E.14.1.1
LrgA holin-like protein (Bayles, 2003; Yang et al., 2005; Ranjit et al. 2011).  Functions in biofilm formation (Ranjit et al. 2011).  Calcium-chelating alizarin and other anthraquinones inhibit biofilm formation and modulate the expression of the cid/lrg genes (encoding the holin/antiholin system) (Lee et al. 2016).

Accession Number:P72358
Protein Name:LrgA
Length:147
Molecular Weight:15780.00
Species:Staphylococcus aureus [93061]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate endolysin

Cross database links:

eggNOG: COG1380
HEGENOM: HBG338218
RefSeq: YP_498827.1   
Entrez Gene ID: 3920307   
Pfam: PF03788   
BioCyc: SAUR93061:SAOUHSC_00232-MONOMER   
KEGG: sao:SAOUHSC_002   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0019835 P:cytolysis
GO:0012501 P:programmed cell death

References (4)

[1] “Identification of LytSR-regulated genes from Staphylococcus aureus.”  Brunskill E.W.et.al.   8824633
[2] “The Staphylococcus aureus lrgAB operon modulates murein hydrolase activity and penicillin tolerance.”  Groicher K.H.et.al.   10714982
[3] “The Staphylococcus aureus cidAB operon: evaluation of its role in regulation of murein hydrolase activity and penicillin tolerance.”  Rice K.C.et.al.   12670989
[4] “Death's toolbox: examining the molecular components of bacterial programmed cell death.”  Rice K.C.et.al.   14617136

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVVKQQKDAS KPAHFFHQVI VIALVLFVSK IIESFMPIPM PASVIGLVLL FVLLCTGAVK 
61:	LGEVEKVGTT LTNNIGLLFV PAGISVVNSL GVISQAPFLI IGLIIVSTIL LLICTGYVTQ 
121:	IIMKVTSRSK GDKVTKKIKI EEAQAHD