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1.E.14.1.2
Holin, CidA (Bayles, 2003; Yang et al., 2005; Ranjit et al. 2011).  Functions in biofilm formation in part by mediating release of cytoplasmic DNA during cell lysis to contribute to the biofilm matrix (Ranjit et al. 2011; Fischer et al. 2013).  This protein contributes to cell lysis of dying cells (Patton et al. 2005).  Calcium-chelating alizarin and other anthraquinones inhibit biofilm formation and modulate the expression of the cid/lrg genes (encoding the holin/antiholin system) (Lee et al. 2016).

Accession Number:P60646
Protein Name:Holin-like protein cidA
Length:131
Molecular Weight:14730.00
Species:Staphylococcus aureus [158879]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate endolysin

Cross database links:

eggNOG: COG1380
HEGENOM: HBG697118
RefSeq: NP_375653.1   
Entrez Gene ID: 1125256   
Pfam: PF03788   
BioCyc: SAUR158879:SA2329-MONOMER   
KEGG: sau:SA2329   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0019835 P:cytolysis
GO:0012501 P:programmed cell death

References (1)

[1] “Whole genome sequencing of meticillin-resistant Staphylococcus aureus.”  Kuroda M.et.al.   11418146

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MHKVQLIIKL LLQLGIIIVI TYIGTEIQKI FHLPLAGSIV GLFLFYLLLQ FKIVPLTWVE 
61:	DGANFLLKTM VFFFIPSVVG IMDVASEITL NYILFFAVII IGTCIVALSS GYIAEKMSVK 
121:	HKHRKGVDAY E