TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.E.17.1.1
BlyA holin-like protein.  When expressed in E. coli, it can release a latent ClyA (HlyE; 1.C.10.1.1) cytolysin from the cell (Ludwig et al. 2008).

Accession Number:Q44828
Protein Name:BlyA aka BBP23 aka BBS23 aka BBR23 aka BBM23 aka BBO23 aka BBL23 aka BBN23 aka BBQ30 aka ORF11
Length:67
Molecular Weight:7478.00
Species:Borrelia burgdorferi (Lyme disease spirochete) [139]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate endolysin

Cross database links:

HEGENOM: HBG037231
RefSeq: NP_051184.1    NP_051226.1    NP_051270.1    NP_051314.1    NP_051356.1    NP_051400.1    NP_051436.1    NP_051492.1    NP_862634.1   
Entrez Gene ID: 1194451    1194483    1194538    1194574    1194632    1194676    1194707    1194766    1343054   
Pfam: PF05102   
BioCyc: BBUR224326:BB_L23-MONOMER    BBUR224326:BB_M23-MONOMER    BBUR224326:BB_N23-MONOMER    BBUR224326:BB_O23-MONOMER    BBUR224326:BB_P23-MONOMER    BBUR224326:BB_Q30-MONOMER    BBUR224326:BB_R23-MONOMER    BBUR224326:BB_S23-MONOMER   
KEGG: bbu:BB_L23    bbu:BB_M23    bbu:BB_O23    bbu:BB_P23    bbu:BB_Q30    bbu:BB_R23    bbu:BB_S23    bbu:BBN23   

References (6)

[1] “Borrelia burgdorferi supercoiled plasmids encode multicopy tandem open reading frames and a lipoprotein gene family.”  Porcella S.F.et.al.   8655511
[2] “Cloning and analysis of a Borrelia burgdorferi membrane-interactive protein exhibiting haemolytic activity.”  Guina T.et.al.   9218769
[3] “Molecular and evolutionary characterization of the cp32/18 family of supercoiled plasmids in Borrelia burgdorferi 297.”  Caimano M.J.et.al.   10678977
[4] “Identification, characterization, and expression of three new members of the Borrelia burgdorferi Mlp (2.9) lipoprotein gene family.”  Yang X.et.al.   10531261
[5] “Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi.”  Fraser C.M.et.al.   9403685
[6] “A bacterial genome in flux: the twelve linear and nine circular extrachromosomal DNAs in an infectious isolate of the Lyme disease spirochete Borrelia burgdorferi.”  Casjens S.et.al.   10672174

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MDTIKLTELL INLNEIKLIA VMIFVTVLVL GVLILLKPLL KDILTIVIGK IFKNGNGNGK 
61:	NHIKKRD