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1.E.3.1.1
Lysis protein TM (gene Y product), 93aas; 3 TMSs, N out; C in (predicted).  This holin has been functionally characterized (To et al. 2013).  It's function is counteracted by the anti-holin, LysA.

Accession Number:P51773
Protein Name:HOLI aka Y
Length:93
Molecular Weight:9818.00
Species:Bacteriophage P2 [10679]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Host cell inner membrane1 / Multi-pass membrane protein2
Substrate endolysin

Cross database links:

RefSeq: NP_046764.1   
Entrez Gene ID: 1261546   
Pfam: PF04550   

Gene Ontology

GO:0020002 C:host cell plasma membrane
GO:0016021 C:integral to membrane
GO:0016998 P:cell wall macromolecule catabolic process
GO:0019835 P:cytolysis

References (1)

[1] “Functions involved in bacteriophage P2-induced host cell lysis and identification of a new tail gene.”  Ziermann R.et.al.   8051010

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTAEEKSVLS LFMIGVLIVV GKVLAGGEPI TPRLFIGRML LGGFVSMVAG VVLVQFPDLS 
61:	LPAVCGIGSM LGIAGYQVIE IAIQRRFKGR GKQ