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1.E.5.1.1
P35 holin of phage PRD1 (Rydman and Bamford 2003; Ziedaite et al. 2005)

Accession Number:Q3T4L9
Protein Name:Holin aka Protein P35
Length:117
Molecular Weight:12778.00
Species:Bacteriophage PRD1 [10658]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Host membrane1 / Multi-pass membrane protein2
Substrate autolysin

Cross database links:

RefSeq: YP_001542615.1   
Entrez Gene ID: 5729504   

Gene Ontology

GO:0033644 C:host cell membrane
GO:0016021 C:integral to membrane
GO:0003824 F:catalytic activity
GO:0016998 P:cell wall macromolecule catabolic process
GO:0019835 P:cytolysis
GO:0042742 P:defense response to bacterium

References (4)

[1] “Genome organization of membrane-containing bacteriophage PRD1.”  Bamford J.K.H.et.al.   1853567
[2] “A snapshot of viral evolution from genome analysis of the tectiviridae family.”  Saren A.M.et.al.   15946683
[3] “Identification and mutational analysis of bacteriophage PRD1 holin protein P35.”  Rydman P.S.et.al.   12813073
[4] “The holin protein of bacteriophage PRD1 forms a pore for small-molecule and endolysin translocation.”  Ziedaite G.et.al.   16030234

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MMENDEWWKY LIFPLVATLG GIVNYSKRAL AMKRFSKLEF AVEAVSAAFV GLMVTLGGAA 
61:	MDLSPHWLGM AAGMSGWMGA DFVKAVFSQF VQSKIAPINQ PGPIDSDNDK PGRTFND