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Toxic protein, HokC or Gef of the Hok/Gef family. When injected into melanoma cells, gef caused the appearance of pore-like structures in the cell membrane (Boulaiz et al. 2003).

Accession Number:P0ACG4
Protein Name:Protein HOKC aka GEF aka B0018.1
Molecular Weight:5502.00
Species:Escherichia coli [83333]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Single-pass type II membrane protein2
Substrate endolysin

Cross database links:

Genevestigator: P0ACG4
EchoBASE: EB0368
EcoGene: EG10373
eggNOG: NOG12921
RefSeq: AP_000682.1    YP_025292.1   
Entrez Gene ID: 2847744   
Pfam: PF01848   
BioCyc: EcoCyc:MONOMER0-1564   
KEGG: ecj:JW5002    eco:b4412   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane

References (6)

[1] “A family of genes encoding a cell-killing function may be conserved in all Gram-negative bacteria.”  Poulsen   2693900
[2] “Systematic sequencing of the Escherichia coli genome: analysis of the 0-2.4 min region.”  Yura   1630901
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi   16738553
[5] “Topographic analysis of the toxic Gef protein from Escherichia coli.”  Poulsen   1943700
[6] “Multiple hok genes on the chromosome of Escherichia coli.”  Pedersen   10361310

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FASTA formatted sequence