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1.G.12 The Avian Leukosis Virus gp95 Fusion Protein (ALV-gp95) Family

Retroviruses rely on low pH to activate their fusion proteins that merge the viral envelope with an endosomal membrane, releasing the viral nucleocapsid into the cytosol (Jha et al., 2011). The fusion process involves a relatively stable hemifusion-like intermediate that precedes fusion pore opening. EnvA (gp95) mediates entry through alternative receptor isoforms and intermediates of virus-endosome fusion (Jha et al., 2011).

References associated with 1.G.12 family:

Apellaniz B., Huarte N., Largo E. and Nieva JL. (2014). The three lives of viral fusion peptides. Chem Phys Lipids. 181:40-55. 24704587
Jha, N.K., O. Latinovic, E. Martin, G. Novitskiy, M. Marin, K. Miyauchi, J. Naughton, J.A. Young, and G.B. Melikyan. (2011). Imaging single retrovirus entry through alternative receptor isoforms and intermediates of virus-endosome fusion. PLoS Pathog 7: e1001260. 21283788