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1.G.12.2.5
The small secreted glycoprotein GP2 of 364 aas, containing the viroporin, GP2-δ, the last 40 aas of GP2 of Zaire ebolavirus (He et al. 2017). This nonstructural polypeptide, called the delta peptide, is produced in abundance during Ebola virus infection. Full length and conserved C-terminal delta peptide fragments permeabilize the plasma membranes of nucleated cells, increase ion permeability across confluent cell monolayers and permeabilize synthetic lipid bilayers. Permeabilization activity is dependent on the disulfide bond between the two conserved cysteines. The conserved C-terminal portion of the peptide is biochemically stable in human serum, and most serum-stable fragments have full activity (He et al. 2017).

Accession Number:ARV89891.1
Protein Name:ARV89891.1 small secreted glycoprotein GP [Zaire ebolavirus]
Length:365
Molecular Weight:
Species:Zaire ebolavirus [186538]
Number of TMSs:1
Substrate

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FASTA formatted sequence
1:	MGVTGILQLP RDRFKRTSFF LWVIILFQRT FSIPLGVIHN STLQVSDVDK LVCRDKLSST 
61:	NQLRSVGLNL EGNGVATDVP SATKRWGFRS GVPPKVVNYE AGEWAENCYN LEIKKPDGSE 
121:	CLPAAPDGIR GFPRCRYVHK VSGTGPCAGD FAFHKEGAFF LYDRLASTVI YRGTTFAEGV 
181:	VAFLILPQAK KDFFSSHPLR EPVNATEDPS SGYYSTTIRY QATGFGTNET EYLFEVDNLT 
241:	YVQLESRFTP QFLLQLNETI YASGKRSNTT GKLIWKVNPE IDTTIGEWAF WETKKTSLEK 
301:	FAVKSCLSQL YQMDPKTSVV RVRRELLPTQ RPTQQMKTTK SWLQKIPLQW FKCTVKEGKL 
361:	QCRI