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1.G.20.2.1
Envelope glycoprotein of 1684 aas and 5 - 8 TMSs, Env-GP, including Gn and Gc (Xiao et al. 2011).  Blocking transport out of multivesicular bodies still allowed virus entry while preventing vesicular acidification, required for membrane fusion, trapping virions in the MVBs (Shtanko et al. 2014).  Entry is dependent on the CCHFV envelope GP (Suda et al. 2016).

Accession Number:Q66034
Protein Name:Envelope glycoprotein
Length:1684
Molecular Weight:186679.00
Species:Crimean-Congo hemorrhagic fever virus [11593]
Number of TMSs:5
Substrate small molecules

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MHISLMYAIL CLQLCGLGET HGSHNETRHN KTDTMTTHGD NPSSEPPVST ALSITLDPST 
61:	VTPTTPASGL EGSGEVYTSP PITTGSLPLS ETTPELPVTT GTDTLSAGDV DPSTQTAGGT 
121:	SAPTVRTSLP NSPSTPSTPQ DTHHPVRNLL SVTSPGPDET STPSGTGKES SATSSPHPVS 
181:	NRPPTPPATA QGPTENDSHN ATEHPESLTQ SATPGLMTSP TQIVHPQSAT PITVQDTHPS 
241:	PTNRSKRNLK MEIILTLSQG LKKYYGKILR LLQLTLEEDT EGLLEWCKRN LGLDCDDTFF 
301:	QKRIEEFFIT GEGHFNEVLQ FRTPGTLSTT ESTPAGLPTA EPFKSYFAKG FLSIDSGYYS 
361:	AKCYSGTSNS GLQLINITRH STRIVDTPGP KITNLKTINC INLKASIFKE HREVEINVLL 
421:	PQVAVNLSNC HVVIKSHVCD YSLDIDGAVR LPHIYHEGVF IPGTYKIVID KKNKLNDRCT 
481:	LFTDCVIKGR EVRKGQSVLR QYKTEIRIGK ASTGFRRLLS EEPSDDCVSR TQLLRTETAE 
541:	IHGDNYGGPG DKITICNGST IVDQRLGSEL GCYTINRVRS FKLCENSATG KNCEIDSVPV 
601:	KCRQGYCLRI TQEGRGHVKL SRGSEVVLDA CDTSCEIMIP KGTGDILVDC SGGQQHFLKD 
661:	NLIDLGCPKI PLLGKMAIYI CRMSNHPKTT MAFLFWFSFG YVITCILCKA IFYLLIIVGT 
721:	LGRRLKQYRE LKPQTCTICE TTPVNAIDAE MHDLNCSYNI CPYCASRLTS DGLARHVIQC 
781:	PKRKEKVEET ELYLNLERIP WVVRKLLQVS ESTGVALKRS SWLIVLLVLF TVSLSPVQSA 
841:	PIGQGKTIEA YRAREGYTSI CLFVLGSILF IVSCLMKGLV DSVGNSFFPG LSICKTCSIS 
901:	SINGFEIESH KCYCSLFCCP YCRHCSTDKE IHKLHLSICK KRKTGSNVML AVCKLMCFRA 
961:	TMEVSNRALF IRSIINTTFV LCILILAVCV VSTSAVEMEN LPAGTWEREE DLTNFCHQEC 
1021:	QVTETECLCP YEALVLRKPL FLDSTAKGMK NLLNSTSLET SLSIEAPWGA INVQSTYKPT 
1081:	VSTANIALSW SSVEHRGNKI LVSGRSESIM KLEERTGISW DLGVEDASES KLLTVSVMDL 
1141:	SQMYSPVFEY LSGDRQVEEW PKATCTGDCP ERCGCTSSTC LHKEWPHSRN WRCNPTWCWG 
1201:	VGTGCTCCGL DVKDLFTDYM FVKWKVEYIK TEAIVCVELT SQERQCSLIE AGTRFNLGPV 
1261:	TITLSEPRNI QQKLPPEIIT LHPRIEEGFF DLMHVQKVLS ASTVCKLQSC THGVPGDLQV 
1321:	YHIGNLLKGD KVNGHLIHKI EPHFNTSWMS WDGCDLDYYC NMGDWPSCTY TGVTQHNHAS 
1381:	FVNLLNIETD YTKNFHFHSK RVTAHGDTPQ LDLKARPTYG AGEITVLVEV ADMELHTKKI 
1441:	EISGLKFASL ACTGCYACSS SISCKVRIHV DEPDELTVHV KSDDPDVVAA SSSLMARKLE 
1501:	FGTDSTFKAF SAMPKTSLCF YIVEREHCKS CSEEDTKKCV NTKLEQPQSI LIEHKGTIIG 
1561:	KQNSTCTAKA SCWLESVKSF FYGLKNMLSG IFGNVFMGIF LFLAPFILLI LFFMFGWRIL 
1621:	FCFKCCRRTR GLFKYRHLKD DEETGYRRII EKLNNKKGKN KLLDGERLAD GRIAELFSTK 
1681:	THIG