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1.G.3.1.1
Tick-borne encephalitis virus (TBEV) (Class II) polyprotein of 3414 aas.  Residues 281 - 776 include the envelop protein that includes the viral fusion protein (Zhang et al. 2017).

Accession Number:P14336
Protein Name:Genome polyprotein
Length:3414
Molecular Weight:378322.00
Species:Tick-borne encephalitis virus European subtype (strain Neudoerfl) PE=1 SV=4 [11088]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Host membrane1 / Multi-pass membrane protein2
Substrate small molecules

Cross database links:

RefSeq: NP_043135.1   
Entrez Gene ID: 1489719   
Pfam: PF01003    PF02832    PF00869    PF01004    PF00948    PF01005    PF01002    PF01350    PF01349    PF00972    PF01570    PF01728    PF00271    PF00949   

Gene Ontology

GO:0033644 C:host cell membrane
GO:0016021 C:integral to membrane
GO:0019031 C:viral envelope
GO:0019013 C:viral nucleocapsid
GO:0005524 F:ATP binding
GO:0003725 F:double-stranded RNA binding
GO:0004482 F:mRNA (guanine-N7-)-methyltransferase activity
GO:0004483 F:mRNA (nucleoside-2'-O-)-methyltransferase a...
GO:0003724 F:RNA helicase activity
GO:0003968 F:RNA-directed RNA polymerase activity
GO:0004252 F:serine-type endopeptidase activity
GO:0005198 F:structural molecule activity
GO:0032259 P:methylation
GO:0016070 P:RNA metabolic process
GO:0006410 P:transcription, RNA-dependent
GO:0019079 P:viral genome replication

References (4)

[1] “The flavivirus 3'-noncoding region: extensive size heterogeneity independent of evolutionary relationships among strains of tick-borne encephalitis virus.”  Wallner G.et.al.   7483260
[2] “Sequence of the structural proteins of tick-borne encephalitis virus (western subtype) and comparative analysis with other flaviviruses.”  Mandl C.W.et.al.   3413985
[3] “Genome sequence of tick-borne encephalitis virus (Western subtype) and comparative analysis of nonstructural proteins with other flaviviruses.”  Mandl C.W.et.al.   2554575
[4] “The envelope glycoprotein from tick-borne encephalitis virus at 2-A resolution.”  Rey F.A.et.al.   7753193
Structure:
1N6G   1NA4   1SVB   1URZ     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MVKKAILKGK GGGPPRRVSK ETATKTRQPR VQMPNGLVLM RMMGILWHAV AGTARNPVLK 
61:	AFWNSVPLKQ ATAALRKIKR TVSALMVGLQ KRGKRRSATD WMSWLLVITL LGMTLAATVR 
121:	KERDGSTVIR AEGKDAATQV RVENGTCVIL ATDMGSWCDD SLSYECVTID QGEEPVDVDC 
181:	FCRNVDGVYL EYGRCGKQEG SRTRRSVLIP SHAQGELTGR GHKWLEGDSL RTHLTRVEGW 
241:	VWKNKLLALA MVTVVWLTLE SVVTRVAVLV VLLCLAPVYA SRCTHLENRD FVTGTQGTTR 
301:	VTLVLELGGC VTITAEGKPS MDVWLDAIYQ ENPAKTREYC LHAKLSDTKV AARCPTMGPA 
361:	TLAEEHQGGT VCKRDQSDRG WGNHCGLFGK GSIVACVKAA CEAKKKATGH VYDANKIVYT 
421:	VKVEPHTGDY VAANETHSGR KTASFTISSE KTILTMGEYG DVSLLCRVAS GVDLAQTVIL 
481:	ELDKTVEHLP TAWQVHRDWF NDLALPWKHE GAQNWNNAER LVEFGAPHAV KMDVYNLGDQ 
541:	TGVLLKALAG VPVAHIEGTK YHLKSGHVTC EVGLEKLKMK GLTYTMCDKT KFTWKRAPTD 
601:	SGHDTVVMEV TFSGTKPCRI PVRAVAHGSP DVNVAMLITP NPTIENNGGG FIEMQLPPGD 
661:	NIIYVGELSH QWFQKGSSIG RVFQKTKKGI ERLTVIGEHA WDFGSAGGFL SSIGKAVHTV 
721:	LGGAFNSIFG GVGFLPKLLL GVALAWLGLN MRNPTMSMSF LLAGGLVLAM TLGVGADVGC 
781:	AVDTERMELR CGEGLVVWRE VSEWYDNYAY YPETPGALAS AIKETFEEGS CGVVPQNRLE 
841:	MAMWRSSVTE LNLALAEGEA NLTVVVDKFD PTDYRGGVPG LLKKGKDIKV SWKSWGHSMI 
901:	WSIPEAPRRF MVGTEGQSEC PLERRKTGVF TVAEFGVGLR TKVFLDFRQE PTHECDTGVM 
961:	GAAVKNGMAI HTDQSLWMRS MKNDTGTYIV ELLVTDLRNC SWPASHTIDN ADVVDSELFL 
1021:	PASLAGPRSW YNRIPGYSEQ VKGPWKYTPI RVIREECPGT TVTINAKCDK RGASVRSTTE 
1081:	SGKVIPEWCC RACTMPPVTF RTGTDCWYAM EIRPVHDQGG LVRSMVVADN GELLSEGGVP 
1141:	GIVALFVVLE YIIRRRPSTG TTVVWGGIVV LALLVTGMVR IESLVRYVVA VGITFHLELG 
1201:	PEIVALMLLQ AVFELRVGLL SAFALRRSLT VREMVTTYFL LLVLELGLPG ASLEEFWKWG 
1261:	DALAMGALIF RACTAEGKTG AGLLLMALMT QQDVVTVHHG LVCFLSVASA CSVWRLLKGH 
1321:	REQKGLTWVV PLAGLLGGEG SGIRLLAFWE LSAHRGRRSF SEPLTVVGVM LTLASGMMRH 
1381:	TSQEALCALA VASFLLLMLV LGTRKMQLVA EWSGCVEWYP ELVNEGGEVS LRVRQDAMGN 
1441:	FHLTELEKEE RMMAFWLIAG LAASAIHWSG ILGVMGLWTL TEMLRSSRRS DLVFSGQGGR 
1501:	ERGDRPFEVK DGVYRIFSPG LFWGQNQVGV GYGSKGVLHT MWHVTRGAAL SIDDAVAGPY 
1561:	WADVREDVVC YGGAWSLEEK WKGETVQVHA FPPGRAHEVH QCQPGELILD TGRKLGAIPI 
1621:	DLVKGTSGSP ILNAQGVVVG LYGNGLKTNE TYVSSIAQGE AEKSRPNLPQ AVVGTGWTSK 
1681:	GQITVLDMHP GSGKTHRVLP ELIRQCIDRR LRTLVLAPTR VVLKEMERAL NGKRVRFHSP 
1741:	AVSDQQAGGA IVDVMCHATY VNRRLLPQGR QNWEVAIMDE AHWTDPHSIA ARGHLYTLAK 
1801:	ENKCALVLMT ATPPGKSEPF PESNGAITSE ERQIPDGEWR DGFDWITEYE GRTAWFVPSI 
1861:	AKGGAIARTL RQKGKSVICL NSKTFEKDYS RVRDEKPDFV VTTDISEMGA NLDVSRVIDG 
1921:	RTNIKPEEVD GKVELTGTRR VTTASAAQRR GRVGRQDGRT DEYIYSGQCD DDDSGLVQWK 
1981:	EAQILLDNIT TLRGPVATFY GPEQDKMPEV AGHFRLTEEK RKHFRHLLTH CDFTPWLAWH 
2041:	VAANVSSVTD RSWTWEGPEA NAVDEASGDL VTFRSPNGAE RTLRPVWKDA RMFKEGRDIK 
2101:	EFVAYASGRR SFGDVLTGMS GVPELLRHRC VSALDVFYTL MHEEPGSRAM RMAERDAPEA 
2161:	FLTMVEMMVL GLATLGVIWC FVVRTSISRM MLGTLVLLAS LLLLWAGGVG YGNMAGVALI 
2221:	FYTLLTVLQP EAGKQRSSDD NKLAYFLLTL CSLAGLVAAN EMGFLEKTKA DLSTALWSER 
2281:	EEPRPWSEWT NVDIQPARSW GTYVLVVSLF TPYIIHQLQT KIQQLVNSAV ASGAQAMRDL 
2341:	GGGAPFFGVA GHVMTLGVVS LIGATPTSLM VGVGLAALHL AIVVSGLEAE LTQRAHKVFF 
2401:	SAMVRNPMVD GDVINPFGEG EAKPALYERK MSLVLATVLC LMSVVMNRTV ASITEASAVG 
2461:	LAAAGQLLRP EADTLWTMPV ACGMSGVVRG SLWGFLPLGH RLWLRASGGR RGGSEGDTLG 
2521:	DLWKRRLNNC TREEFFVYRR TGILETERDK ARELLRRGET NVGLAVSRGT AKLAWLEERG 
2581:	YATLKGEVVD LGCGRGGWSY YAASRPAVMS VRAYTIGGKG HEAPKMVTSL GWNLIKFRSG 
2641:	MDVFSMQPHR ADTVMCDIGE SSPDAAVEGE RTRKVILLME QWKNRNPTAA CVFKVLAPYR 
2701:	PEVIEALHRF QLQWGGGLVR TPFSRNSTHE MYYSTAVTGN IVNSVNVQSR KLLARFGDQR 
2761:	GPTKVPELDL GVGTRCVVLA EDKVKEQDVQ ERIRALREQY SETWHMDEEH PYRTWQYWGS 
2821:	YRTAPTGSAA SLINGVVKLL SWPWNAREDV VRMAMTDTTA FGQQRVFKDK VDTKAQEPQP 
2881:	GTRVIMRAVN DWILERLAQK SKPRMCSREE FIAKVKSNAA LGAWSDEQNR WASAREAVED 
2941:	PAFWRLVDEE RERHLMGRCA HCVYNMMGKR EKKLGEFGVA KGSRAIWYMW LGSRFLEFEA 
3001:	LGFLNEDHWA SRESSGAGVE GISLNYLGWH LKKLSTLNGG LFYADDTAGW DTKVTNADLE 
3061:	DEEQILRYME GEHKQLATTI MQKAYHAKVV KVARPSRDGG CIMDVITRRD QRGSGQVVTY 
3121:	ALNTLTNIKV QLIRMMEGEG VIEAADAHNP RLLRVERWLK EHGEERLGRM LVSGDDCVVR 
3181:	PLDDRFGKAL YFLNDMAKTR KDIGEWEHSA GFSSWEEVPF CSHHFHELVM KDGRTLVVPC 
3241:	RDQDELVGRA RISPGCGWSV RETACLSKAY GQMWLLSYFH RRDLRTLGLA INSAVPADWV 
3301:	PTGRTTWSIH ASGAWMTTED MLDVWNRVWI LDNPFMQNKE RVMEWRDVPY LPKAQDMLCS 
3361:	SLVGRRERAE WAKNIWGAVE KVRKMIGPEK FKDYLSCMDR HDLHWELRLE SSII