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|---|---|
| Accession Number: | Q9Y5I7 |
| Protein Name: | Cldn16 |
| Length: | 305 |
| Molecular Weight: | 33836.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 4 |
| Location1 / Topology2 / Orientation3: | Cell junction1 / Multi-pass membrane protein2 |
Cross database links:
| Genevestigator: | Q9Y5I7 |
|---|---|
| HEGENOM: | HBG280494 |
| RefSeq: | NP_006571.1 |
| Entrez Gene ID: | 10686 |
| Pfam: | PF00822 |
| OMIM: |
248250 phenotype 603959 gene |
| KEGG: | hsa:10686 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005923
C:tight junction
GO:0042802
F:identical protein binding
GO:0015095
F:magnesium ion transmembrane transporter act...
GO:0005198
F:structural molecule activity
GO:0016338
P:calcium-independent cell-cell adhesion
GO:0006875
P:cellular metal ion homeostasis
GO:0007588
P:excretion
GO:0006811
P:ion transport
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References (4)[1] “Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption.” Simon D.B.et.al. 10390358 [2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [3] “Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis maps to chromosome 3q27 and is associated with mutations in the PCLN-1 gene.” Weber S.et.al. 10878661 [4] “Novel paracellin-1 mutations in 25 families with familial hypomagnesemia with hypercalciuria and nephrocalcinosis.” Weber S.et.al. 11518780
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | |||
| FASTA formatted sequence |
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1: MTSRTPLLVT ACLYYSYCNS RHLQQGVRKS KRPVFSHCQV PETQKTDTRH LSGARAGVCP 61: CCHPDGLLAT MRDLLQYIAC FFAFFSAGFL IVATWTDCWM VNADDSLEVS TKCRGLWWEC 121: VTNAFDGIRT CDEYDSILAE HPLKLVVTRA LMITADILAG FGFLTLLLGL DCVKFLPDEP 181: YIKVRICFVA GATLLIAGTP GIIGSVWYAV DVYVERSTLV LHNIFLGIQY KFGWSCWLGM 241: AGSLGCFLAG AVLTCCLYLF KDVGPERNYP YSLRKAYSAA GVSMAKSYSA PRTETAKMYA 301: VDTRV
