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1.H.1.1.10
Claudin 10a (Claudin-10a; isoform 1) has an anion-selective paracellular channel (Angelow et al., 2008) while Claudin 10b (Claudin-10b; isoform 2) has a cation-selective paracellular channel (Milatz and Breiderhoff 2017).

Accession Number:Q9Z0S6
Protein Name:Cldn10a
Length:231
Molecular Weight:24693.00
Species:Mus musculus [10090]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell junction1 / Multi-pass membrane protein2
Substrate anions, cations

Cross database links:

Genevestigator: Q9Z0S6
HEGENOM: HBG716859
Pfam: PF00822   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005923 C:tight junction
GO:0042802 F:identical protein binding
GO:0005198 F:structural molecule activity
GO:0016338 P:calcium-independent cell-cell adhesion

References (1)

[1] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MASTALEIVA FVVSISGWVL VSSTLPTDYW KVSTIDGTVI TTATYFANLW KICVTDSTGV 
61:	ANCKEFPSML ALDGYIQACR GLMIAAVSLG FFGSIFALFG MKCTKVGGSD QAKAKIACLA 
121:	GIVFILSGLC SMTGCSLYAN KITTEFFDPL YMEQKYELGA ALFIGWAGAS LCIIGGVIFC 
181:	FSISDNNKTP RMGYTYNGPT SVMSSRTKYQ GGEGDFKTAG PSKQFDKNAY V