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1.H.1.1.11
Claudin 2 (Claudin-2) (forms narrow, fluid filled, water-permeable cation-selective paracellular pores) (Angelow et al., 2008; Yu et al., 2009).  It is a dimer in a high molecular weight protein complex (Van Itallie et al. 2011; Krug et al. 2014). Transports Na+, K+, smal organic molecules and water through the paracellular channel (Fromm et al. 2017). Site-specific distributions of claudin-2- and claudin-15-based paracellular channels drive their organ-specific functions in the liver, kidney, and intestine (Tanaka et al. 2017). Disruption of the gastrointestinal epithelial barrier is a hallmark of chronic inflammatory bowel diseases (IBDs), and in the intestines of patients with IBDs, the expression of CLDN2 is upregulated (Takigawa et al. 2017).

Accession Number:O88552
Protein Name:Cldn2
Length:230
Molecular Weight:24484.00
Species:Mus musculus [10090]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell junction1 / Multi-pass membrane protein2
Substrate K+, Na+, water, cations

Cross database links:

Genevestigator: O88552
HEGENOM: HBG716859
RefSeq: NP_057884.1   
Entrez Gene ID: 12738   
Pfam: PF00822   
KEGG: mmu:12738   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005923 C:tight junction
GO:0042802 F:identical protein binding
GO:0005198 F:structural molecule activity
GO:0016338 P:calcium-independent cell-cell adhesion

References (7)

[1] “Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin.”  Furuse M.et.al.   9647647
[2] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Ca(2+)-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions.”  Kubota K.et.al.   10508613
[5] “Manner of interaction of heterogeneous claudin species within and between tight junction strands.”  Furuse M.et.al.   10562289
[6] “Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins.”  Itoh M.et.al.   10601346
[7] “Cloning of the human claudin-2 5'-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alpha.”  Sakaguchi T.et.al.   11934881
Structure:
4P5H     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MASLGVQLVG YILGLLGLLG TSIAMLLPNW RTSSYVGASI VTAVGFSKGL WMECATHSTG 
61:	ITQCDIYSTL LGLPADIQAA QAMMVTSSAM SSLACIISVV GMRCTVFCQD SRAKDRVAVV 
121:	GGVFFILGGI LGFIPVAWNL HGILRDFYSP LVPDSMKFEI GEALYLGIIS ALFSLVAGVI 
181:	LCFSCSPQGN RTNYYDGYQA QPLATRSSPR SAQQPKAKSE FNSYSLTGYV