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1.H.1.1.12
Claudin-15 of 227 aas and 4 TMSs, Cldn15.  Suzuki et al. 2013 reported the crystal structure of mouse claudin-15 at a resolution of 2.4 angstroms. The structure revealed a characteristic β-sheet fold consisting of two extracellular segments anchored to a transmembrane four-helix bundle by a consensus motif. Potential paracellular pathways with distinctive charges on the extracellular surface provided insight into the molecular basis of ion homeostasis across tight junctions. Site-specific distributions of claudin-2- and claudin-15-based paracellular channels drive their organ-specific functions in the liver, kidney, and intestine (Tanaka et al. 2017). A model of the claudin-15-based paracellular channel has been presented (Alberini et al. 2017).

Accession Number:Q9Z0S5
Protein Name:Claudin-15
Length:227
Molecular Weight:24280.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell junction1
Substrate ions

Cross database links:

Structure:
4P79     

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FASTA formatted sequence
1:	MSVAVETFGF FMSALGLLML GLTLSNSYWR VSTVHGNVIT TNTIFENLWY SCATDSLGVS 
61:	NCWDFPSMLA LSGYVQGCRA LMITAILLGF LGLFLGMVGL RCTNVGNMDL SKKAKLLAIA 
121:	GTLHILAGAC GMVAISWYAV NITTDFFNPL YAGTKYELGP ALYLGWSASL LSILGGICVF 
181:	STCCCSSKEE PATRAGLPYK PSTVVIPRAT SDESDISFGK YGKNAYV