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1.H.1.1.2
Claudin 7 (anion selective; Angelow et al., 2008).  25% identity with Cldn 16; down regulated in breast cancer. 

Accession Number:O95471
Protein Name:Cldn7
Length:211
Molecular Weight:22390.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell junction1 / Multi-pass membrane protein2
Substrate anions

Cross database links:

Genevestigator: O95471
eggNOG: prNOG11243
HEGENOM: HBG716859
RefSeq: NP_001298.3   
Entrez Gene ID: 1366   
Pfam: PF00822   
OMIM: 609131  gene
KEGG: hsa:1366   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005923 C:tight junction
GO:0042802 F:identical protein binding
GO:0005198 F:structural molecule activity
GO:0016338 P:calcium-independent cell-cell adhesion

References (4)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Regulation of the expression of the prostate-specific antigen by claudin-7.”  Zheng J.-Y.et.al.   14502431
[4] “Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast.”  Kominsky S.L.et.al.   12673207

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MANSGLQLLG FSMALLGWVG LVACTAIPQW QMSSYAGDNI ITAQAMYKGL WMDCVTQSTG 
61:	MMSCKMYDSV LALSAALQAT RALMVVSLVL GFLAMFVATM GMKCTRCGGD DKVKKARIAM 
121:	GGGIIFIVAG LAALVACSWY GHQIVTDFYN PLIPTNIKYE FGPAIFIGWA GSALVILGGA 
181:	LLSCSCPGNE SKAGYRAPRS YPKSNSSKEY V