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1.H.1.1.3
Claudin 22 (function unknown; distantly related to most claudins)

Accession Number:Q8N7P3
Protein Name:Cldn22
Length:220
Molecular Weight:24509.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell junction1 / Multi-pass membrane protein2
Substrate ions

Cross database links:

Genevestigator: Q8N7P3
eggNOG: prNOG20197
HEGENOM: HBG716859
RefSeq: NP_001104789.1   
Entrez Gene ID: 53842   
Pfam: PF00822   
KEGG: hsa:53842   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005923 C:tight junction
GO:0042802 F:identical protein binding
GO:0005198 F:structural molecule activity
GO:0016338 P:calcium-independent cell-cell adhesion

References (2)

[1] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MALVFRTVAQ LAGVSLSLLG WVLSCLTNYL PHWKNLNLDL NEMENWTMGL WQTCVIQEEV 
61:	GMQCKDFDSF LALPAELRVS RILMFLSNGL GFLGLLVSGF GLDCLRIGES QRDLKRRLLI 
121:	LGGILSWASG VTALVPVSWV AHKTVQEFWD ENVPDFVPRW EFGEALFLGW FAGLSLLLGG 
181:	CLLHCAACSS HAPLASGHYA VAQTQDHHQE LETRNTNLKH