TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.H.1.1.4
Claudin 23 (function unknown; distantly related to most claudins including Cldn 22). Related to cancer invasion/metastasis; it may regulate these phenomena through activation of the MEK signalling pathway in pancreatic cancer (Wang et al., 2010). Shows reduced levels in atopic dermatitis (De Benedetto et al., 2011).

Accession Number:Q96B33
Protein Name:Cldn23
Length:292
Molecular Weight:31915.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Cell junction1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

Genevestigator: Q96B33
RefSeq: NP_919260.2   
Entrez Gene ID: 137075   
Pfam: PF00822   
OMIM: 609203  gene
KEGG: hsa:137075   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005923 C:tight junction
GO:0042802 F:identical protein binding
GO:0005198 F:structural molecule activity
GO:0016338 P:calcium-independent cell-cell adhesion

References (3)

[1] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[2] “CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family.”  Katoh M.et.al.   12736707
[3] “Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.”  Rikova K.et.al.   18083107

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MRTPVVMTLG MVLAPCGLLL NLTGTLAPGW RLVKGFLNQP VDVELYQGLW DMCREQSSRE 
61:	RECGQTDQWG YFEAQPVLVA RALMVTSLAA TVLGLLLASL GVRCWQDEPN FVLAGLSGVV 
121:	LFVAGLLGLI PVSWYNHFLG DRDVLPAPAS PVTVQVSYSL VLGYLGSCLL LLGGFSLALS 
181:	FAPWCDERCR RRRKGPSAGP RRSSVSTIQV EWPEPDLAPA IKYYSDGQHR PPPAQHRKPK 
241:	PKPKVGFPMP RPRPKAYTNS VDVLDGEGWE SQDAPSCSTH PCDSSLPCDS DL