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1.H.1.1.6
Claudin 4 (209aas) forms paracellular chloride channels in the kidney collecting duct and requires Claudin 8 for tight junctions localization (Hou et al., 2010).

Accession Number:O14493
Protein Name:Claudin-4
Length:209
Molecular Weight:22077.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell junction1
Substrate Cl-

Cross database links:

Genevestigator: O14493
eggNOG: prNOG11270
HEGENOM: HBG716859
Entrez Gene ID: 1364   
Pfam: PF00822   
KEGG: hsa:1364   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005923 C:tight junction
GO:0042802 F:identical protein binding
GO:0005198 F:structural molecule activity
GO:0004888 F:transmembrane receptor activity
GO:0016338 P:calcium-independent cell-cell adhesion

References (2)

[1] “Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo.”  Katahira J.et.al.   9334247
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
Structure:
5b2g     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MASMGLQVMG IALAVLGWLA VMLCCALPMW RVTAFIGSNI VTSQTIWEGL WMNCVVQSTG 
61:	QMQCKVYDSL LALPQDLQAA RALVIISIIV AALGVLLSVV GGKCTNCLED ESAKAKTMIV 
121:	AGVVFLLAGL MVIVPVSWTA HNIIQDFYNP LVASGQKREM GASLYVGWAA SGLLLLGGGL 
181:	LCCNCPPRTD KPYSAKYSAA RSAAASNYV