TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.H.1.1.8
PM22_Claudin family (CLDN_18A2.1; CRA_C; 264 aas)

Accession Number:P56857
Protein Name:Claudin-18A2.1 aka Cldn18
Length:264
Molecular Weight:28122.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell junction1 / Multi-pass membrane protein2
Substrate ions

Cross database links:

Genevestigator: P56857
eggNOG: roNOG09605
HEGENOM: HBG716859
RefSeq: NP_062789.1   
Entrez Gene ID: 56492   
Pfam: PF00822   
KEGG: mmu:56492   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005923 C:tight junction
GO:0042802 F:identical protein binding
GO:0005198 F:structural molecule activity
GO:0016338 P:calcium-independent cell-cell adhesion

References (2)

[1] “Claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing.”  Niimi T.et.al.   11585919
[2] “Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry.”  Dai J.et.al.   17203969

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MATTTCQVVG LLLSLLGLAG CIAATGMDMW STQDLYDNPV TAVFQYEGLW RSCVQQSSGF 
61:	TECRPYFTIL GLPAMLQAVR ALMIVGIVLG VIGILVSIFA LKCIRIGSMD DSAKAKMTLT 
121:	SGILFIISGI CAIIGVSVFA NMLVTNFWMS TANMYSGMGG MGGMVQTVQT RYTFGAALFV 
181:	GWVAGGLTLI GGVMMCIACR GLTPDDSNFK AVSYHASGQN VAYRPGGFKA STGFGSNTRN 
241:	KKIYDGGART EDDEQSHPTK YDYV