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1.H.1.4.6
Ecm7, (448aas; 4 TMS), is a member of the PMP-22/EMP/MP20 Claudin superfamily of transmembrane proteins that includes gamma-subunits of voltage-gated calcium channels.  It appears to interact with Mid1 and regulate the activity of the Cch1/Mid1 channel (TC# 1.A.1.11.10; Martin et al., 2011). Ecm7p is related to members of TC families 1.H.1, 1.H.2 and 1.A.81.

Accession Number:Q06200
Protein Name:Protein ECM7
Length:448
Molecular Weight:50328.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+

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FASTA formatted sequence
1:	MVMSRIRDTI ARPFQNLTAL EKVVQWLRLG TTLLIISFGL ALTVGPLSSP RTLYMSRLDT 
61:	YSADITTGLF TVLRESMEQS TSTEENNGVG LTTSELYILT AYTESQIKNV PQYITVSLYG 
121:	RCDSTYTMVE VFDSEGNMHS VKNSTTKSTC SSIGTDYLFD YREVLESLGL DIILDYAYNK 
181:	IGSQQAESSA YTTYMRSLKH KKANVLHLLY AVISFQVCML FFMIWYYYIK GRFMNALKER 
241:	ALVHINSLLS LVVFIGGLIS SISLAWVNYT IQSRINTELE AFGFSYHLGV TWFALLWCFA 
301:	GLISVSCLAW SGLEWCISDN GTSYGGGIDD KFLGYQAGVF TDADLDDETS YSQRYPQRQS 
361:	TSGEAELMRN SDTMATIRKT SDVDLNSEND ANTSLDHGNP TANISNGGKH EPFATREEFE 
421:	LQDIRFRSSN DSEESMQRVI KPSSALQF