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1.H.2 The Invertebrate PMP22-Claudin (Claudin2) Family

Claudins are integral transmembrane components of tight junctions (TJs), forming trans-epithelial barriers in many organs, such as the nervous system, lungs and epidermis. In Drosophila, three claudins have been identified which are required for forming the TJ analogous structures - the septate junctions (SJs). The lack of claudins results in disruption of the integrity of the SJs, leading to the breakdown of the trans-epithelial barrier and disturbed epithelial morphogenesis. These homologues are involved in transport and membrane organization. They associate with over 100 proteins in the Drosophila proteome (Jaspers et al., 2012).

References associated with 1.H.2 family:

Jaspers MH., Nolde K., Behr M., Joo SH., Plessmann U., Nikolov M., Urlaub H. and Schuh R. (2012). The claudin Megatrachea protein complex. J Biol Chem. 287(44):36756-65. 22930751