TCDB is operated by the Saier Lab Bioinformatics Group

2.A.1 The Major Facilitator Superfamily (MFS)

The MFS is a very old, large and diverse superfamily that includes over 10,000 sequenced members. They catalyze uniport, solute:cation (H+ or Na+) symport and/or solute:H+ or solute:solute antiport. Most are of 400-600 amino acyl residues in length and possess either 12, 14 or 24 putative transmembrane α-helical spanners. The mechanistic principles applicable to all MFS carriers have been summarized by Law et al (2008). The 24 TMS MFS permease, NarK, of Paracoccus pantotrophus has two 12 TMS domains, NarK1 and NarK2, both of which are required for normal nitrate uptake. NarK1 catalyzes NO3-:H+ symport, dependent on the pmf, while NarK2 catalyzes NO3-:NO2- antiport, independent of the pmf (Wood et al., 2002). Thus, the protein is a fusion protein of two homologous but distinct MFS permeases.

MFS permeases exhibit specificity for sugars, polyols, drugs, neurotransmitters, Krebs cycle metabolites, phosphorylated glycolytic intermediates, amino acids, peptides, osmolites, siderophores (efflux), iron-siderophores (uptake), nucleosides, organic anions, inorganic anions, etc. They are found ubiquitously in all three kingdoms of living organisms. One member of the DHA2 family with 14 spanners, the TetL Me2+ · tetracycline:H+ antiporter of B. subtilis (TC #2.A.1.3.16), which also exhibits monovalent ion antiport activity, can be converted to a monovalent cation (Na+, K+, H+) antiporter with no tetracycline transport activity by deletion of TMSs 7 and 8, the two central and extra TMSs (Jin et al., 2001). Genome analyses of MFS permeases have been published (Lorca et al., 2007).

A 6.5 Å resolution structure for the MFS permease, OxlT (TC #2.A.1.11.1) has been obtained (Heymann et al., 2001; Hirai et al., 2002) which shows the positions of the transmembrane α-helices but does not allow assignment of the TMS # to these helices. Molecular modeling (Hirai et al., 2003) led to the suggestion that the 12 TMS protein arose from a 3 TMS element by two successive duplication events. The same suggestion resulted from sequence comparisons showing that the primordial 3 TMS element may have arisen from a VIC family (TC #1.A.1) 2 TMS channel-forming unit Hvorup & Saier, (2002). TMSs 3, 6, 9 and 12 are hydrophobic while TMSs 1, 2, 4, 5, 7, 8, 10 and 11 line the channel. The protein may exhibit 4 fold symmetry.

The high-resolution 3-dimensional structures (3.3 and 3.5 Å resolution) of the glycerol-3-P:P antiporter (GlpT; TC #2.A.1.4.3) and the lactose:H+ symporter (LacY; TC #2.A.1.5.1), respectively (Huang et al., 2003 and Abramson et al., 2003, respectively; see also Locher et al., 2003; Guan et al., 2007) have been determined. These structures reveal the 2-fold symmetry expected, based on sequence similarity of the two halves. However, the 4-fold symmetry seen in the OxlT structure was not observed. The substrate pathway is predicted to exist between the two halves of the permeases using an alternating access mechanism with a single substrate binding site (Huang et al., 2003). This mechanism is termed a 'rocker switch' type of movement.

MFS antiporters operate via a single binding site, alternating-access mechanism that involves a rocker-switch type movement of the two halves of the protein (Law et al., 2008). In the sn-glycerol-3-phosphate transporter (GlpT) from Escherichia coli, the substrate-binding site is formed by several charged residues and a histidine that can be protonated. Salt-bridge formation and breakage are involved in the conformational changes of the protein during transport (Law et al., 2008).

Vesicular glutamate transporters (VGLUTs [2.A.1.14.13 and 2.A.1.14.16]) are responsible for the vesicular storage of L-glutamate and play an essential role in glutamatergic signal transmission in the central nervous system. VGLUT2 facilitates L-glutamate uptake in a membrane potential (ΔΨ)-dependent fashion. Uptake exhibits an absolute requirement for ~4 mM Cl- and was sensitive to Evans blue, but was insensitive to D,L-aspartate. VGLUT2s with mutations in the transmembrane-located residues Arg184, His128, and Glu191 showed a dramatic loss in L-glutamate transport activity, whereas Na+-dependent inorganic phosphate (Pi) uptake remained comparable to that of the wild type. Furthermore, Pi transport did not require Cl- and was not inhibited by Evans blue. Thus, VGLUT2 appears to possess two intrinsic transport machineries that are independent of each other: a ΔΨ-dependent L-glutamate uptake and a Na+-dependent Pi uptake (Juge et al., 2006). 

Trichoderma spp. are avirulent, fungal, opportunistic plant symbionts present in nearly all climatic soils. These Trichoderma strains produce secondary metabolites that are potent bio-control agents against microbial pathogens and also can be plant growth promoters. The MFS includes a large proportion of efflux-pumps which are linked with membrane transport of these secondary metabolites in T. reesei (Chaudhary et al. 2016).

The generalized transport reactions catalyzed by MFS porters are:

(1) Uniport: S (out) ⇌ S (in).

(2) Symport: S (out) + [H+ or Na+] (out) ⇌ S (in) + [H+ or Na+] (in).

(3) Antiport: S1 (out) + S2 (in) ⇌ S1 (in) + S2 (out) (S1 may be H+ or a solute).


This family belongs to the: MFS Superfamily.

References associated with 2.A.1 family:

Abbas, A., J.E. McGuire, D. Crowley, C. Baysse, M. Dow, and F. O'Gara. (2004). The putative permease PhlE of Pseudomonas fluorescens F113 has a role in 2,4-diacetylphloroglucinol resistance and in general stress tolerance. Microbiology 150: 2443-2450. 15256586
Abdulhussein AA. and Wallace HM. (2014). Polyamines and membrane transporters. Amino Acids. 46(3):655-60. 23851697
Abramson, J., I. Smirnova, V. Kasho, G. Verner, H.R. Kaback, and S. Iwata. (2003). Structure and mechanism of the lactose permease of Escherichia coli. Science 301: 610-615. 12893935
AbuAli, G. and S. Grimm. (2014). Isolation and Characterization of the Anticancer Gene Organic Cation Transporter Like-3 (ORCTL3). Adv Exp Med Biol 818: 213-227. 25001539
Adler, J. and E. Bibi. (2004). Determinants of substrate recognition by the Escherichia coli multidrug transporter MdfA identified on both sides of the membrane. J. Biol. Chem. 279: 8957-8965. 14688269
Ai, P., S. Sun, J. Zhao, X. Fan, W. Xin, Q. Guo, L. Yu, Q. Shen, P. Wu, A.J. Miller, and G. Xu. (2009). Two rice phosphate transporters, OsPht1;2 and OsPht1;6, have different functions and kinetic properties in uptake and translocation. Plant J. 57: 798-809. 18980647
Alexander, N.J., S.P. McCormick, and T.M. Hohn. (1999). TRI12, a trichothecene efflux pump from Fusarium sporotrichioides: gene isolation and expression in yeast. Mol. Gen. Genet. 261: 977-984. 10485289
Alfonso, A., K. Grundahl, J.R. McManus, J.M. Asbury, and J.B. Rand. (1994). Alternative splicing leads to two cholinergic proteins in Caenorhabditis elegans. J. Mol. Biol. 241: 627-630. 8057385
Allard, K.A., V. K. Viswanathan, and N.P. Cianciotto. (2006). lbtA and lbtB Are Required for Production of the Legionella pneumophila Siderophore Legiobactin. J. Bacteriol. 188: 1351-1363. 16452417
Almaguer, C., E. Fisher, and J. Patton-Vogt. (2006). Posttranscriptional regulation of Git1p, the glycerophosphoinositol/glycerophosphocholine transporter of Saccharomyces cerevisiae. Curr. Genet. 50: 367-375. 16924500
Aluri, S. and M. Büttner. (2007). Identification and functional expression of the Arabidopsis thaliana vacuolar glucose transporter 1 and its role in seed germination and flowering. Proc. Natl. Acad. Sci. U.S.A. 104: 2537-2542. 17284600
Alvarez, F.J., and J.B. Konopka. (2007). Identification of an N-acetylglucosamine transporter that mediates hyphal induction in Candida albicans. Mol. Biol. Cell. 18: 965-975. 17192409
Ambrose, K.D., R. Nisbet, and D.S. Stephens. (2005). Macrolide efflux in Streptococcus pneumoniae is mediated by a dual efflux pump (mel and mef) and is erythromycin inducible. Antimicrob. Agents Chemother. 49: 4203-4209. 16189099
Amilhon, B., E. Lepicard, T. Renoir, R. Mongeau, D. Popa, O. Poirel, S. Miot, C. Gras, A.M. Gardier, J. Gallego, M. Hamon, L. Lanfumey, B. Gasnier, B. Giros, and S. El Mestikawy. (2010). VGLUT3 (vesicular glutamate transporter type 3) contribution to the regulation of serotonergic transmission and anxiety. J. Neurosci. 30: 2198-2210. 20147547
Anderson, P.M., Y.C. Sung, and J.A. Fuchs. (1990). The cyanase operon and cyanate metabolism. FEMS Microbiol. Rev. 7: 247-252. 2094285
Anzai, N. and H. Endou. (2011). Urate transporters: an evolving field. Semin Nephrol 31: 400-409. 22000646
Anzai, N., H. Miyazaki, R. Noshiro, S. Khamdang, A. Chairoungdua, J.-J. Shin, A. Enomoto, S. Sakamoto, T. Hirata, K. Tomita, Y. Kanai, and H. Endou. (2004). The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus. J. Biol. Chem. 279: 45942-45950. 15304510
Anzai, N., K. Ichida, P. Jutabha, T. Kimura, E. Babu, C.J. Jin, S. Srivastava, K. Kitamura, I. Hisatome, H. Endou, and H. Sakurai. (2008). Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans. J. Biol. Chem. 283: 26834-26838. 18701466
AONO, K. (1962). [Studies on protein in gallstone]. Fukuoka Igaku Zasshi 53: 897-926. 14013424
Aouameur, R., S. Da Cal, P. Bissonnette, M.J. Coady, and J.Y. Lapointe. (2007). SMIT2 mediates all myo-inositol uptake in apical membranes of rat small intestine. Am. J. Physiol. Gastrointest. Liver. Physiol. 293(6):G1300-G1307.
Araki N., Suzuki T., Miyauchi K., Kasai D., Masai E. and Fukuda M. (201). Identification and characterization of uptake systems for glucose and fructose in Rhodococcus jostii RHA1. J Mol Microbiol Biotechnol. 20(3):125-36. 21464575
Arjona, F.J., E. de Vrieze, T.J. Visser, G. Flik, and P.H. Klaren. (2011). Identification and functional characterization of zebrafish solute carrier Slc16a2 (Mct8) as a thyroid hormone membrane transporter. Endocrinology 152: 5065-5073. 21952246
Babu, E., Y. Kanai, A. Chairoungdua, D.K. Kim, Y. Iribe, S. Tangtrongsup, P. Jutabha, Y. Li, N. Ahmed, S. Sakamoto, N. Anzai, S. Nagamori, and H. Endou. (2003). Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. J. Biol. Chem. 278: 43838-43845. 12930836
Bacher, P., S. Giersiefer, M. Bach, C. Fork, E. Schömig, and D. Gründemann. (2009). Substrate discrimination by ergothioneine transporter SLC22A4 and carnitine transporter SLC22A5: gain-of-function by interchange of selected amino acids. Biochim. Biophys. Acta. 1788: 2594-2602. 19814996
Bahn, A., Y. Hagos, S. Reuter, D. Balen, H. Brzica, W. Krick, B.C. Burckhardt, I. Sabolic, and G. Burckhardt. (2008). Identification of a New Urate and High Affinity Nicotinate Transporter, hOAT10 (SLC22A13). J. Biol. Chem. 283: 16332-16341. 18411268
Bai J., Mosley L. and Fralick JA. (2010). Evidence that the C-terminus of OprM is involved in the assembly of the VceAB-OprM efflux pump. FEBS Lett. 584(8):1493-7. 20206171
Baker, J., S.H. Wright, and F. Tama. (2012). Simulations of substrate transport in the multidrug transporter EmrD. Proteins 80: 1620-1632. 22434745
Baldwin, S.A. (1993). Mammalian passive glucose transporters: members of an ubiquitous family of active and passive transport proteins. Biochim. Biophys. Acta 1154: 17-49. 8507645
Balmaceda-Aguilera C., Martos-Sitcha JA., Mancera JM. and Martinez-Rodriguez G. (2012). Cloning and expression pattern of facilitative glucose transporter 1 (GLUT1) in gilthead sea bream Sparus aurata in response to salinity acclimation. Comp Biochem Physiol A Mol Integr Physiol. 163(1):38-46. 22580053
Baltazar, F., C. Pinheiro, F. Morais-Santos, J. Azevedo-Silva, O. Queirós, A. Preto, and M. Casal. (2014). Monocarboxylate transporters as targets and mediators in cancer therapy response. Histol Histopathol 29: 1511-1524. 24921258
Bannam, T.L., P.A. Johanesen, C.L. Salvado, S.J. Pidot, K.A. Farrow, and J.I. Rood. (2004). The Clostridium perfringens TetA(P) efflux protein contains a functional variant of the Motif A region found in major facilitator superfamily transport proteins. Microbiology 150: 127-134. 14702405
Bansal, A., D. Mallik, D. Kar, and A.S. Ghosh. (2016). Identification of a multidrug efflux pump in Mycobacterium smegmatis. FEMS Microbiol. Lett. [Epub: Ahead of Print] 27190152
Bapna, A., L. Federici, H. Venter, S. Velamakanni, B. Luisi, T.P. Fan, and H.W. van Veen. (2007). Two proton translocation pathways in a secondary active multidrug transporter. J. Mol. Microbiol. Biotechnol. 12: 197-209. 17587868
Baranova, N. and H. Nikaido. (2002). The baeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate. J. Bacteriol. 184: 4168-4176. 12107134
Barton, A., S. Eyre, J. Bowes, P. Ho, S. John, and J. Worthington. (2005). Investigation of the SLC22A4 gene (associated with rheumatoid arthritis in a Japanese population) in a United Kingdom population of rheumatoid arthritis patients. Arthritis Rheum 52: 752-758. 15751072
Baruffini, E., P. Goffrini, C. Donnini, and T. Lodi. (2006). Galactose transport in Kluyveromyces lactis: major role of the glucose permease Hgt1. FEMS Yeast Research DOI: 10.1111/j.1364.2006.00107.x. 17156020
Basso LR Jr., Gast CE., Mao Y. and Wong B. (2010). Fluconazole transport into Candida albicans secretory vesicles by the membrane proteins Cdr1p, Cdr2p, and Mdr1p. Eukaryot Cell. 9(6):960-70. 20348384
Beasley, F.C., E.D. Vinés, J.C. Grigg, Q. Zheng, S. Liu, G.A. Lajoie, M.E. Murphy, and D.E. Heinrichs. (2009). Characterization of staphyloferrin A biosynthetic and transport mutants in Staphylococcus aureus. Mol. Microbiol. 72: 947-963. 19400778
Beaudoin, J., R. Ioannoni, L. López-Maury, J. Bähler, S. Ait-Mohand, B. Guérin, S.C. Dodani, C.J. Chang, and S. Labbé. (2011). Mfc1 is a novel forespore membrane copper transporter in meiotic and sporulating cells. J. Biol. Chem. 286: 34356-34372. 21828039
Becker, H.M. and J.W. Deitmer. (2008). Nonenzymatic proton handling by carbonic anhydrase II during H+-lactate cotransport via monocarboxylate transporter 1. J. Biol. Chem. 283: 21655-21667. 18539591
Becker, H.M., D. Hirnet, C. Fecher-Trost, D. Sultemeyer, and J.W. Deitmer. (2005). Transport activity of MCT1 expressed in Xenopus oocytes is increased by interaction with carbonic anhydrase. J. Biol. Chem. 280: 39882-39889. 16174776
Becker, H.M., M. Klier, and J.W. Deitmer. (2010). Nonenzymatic augmentation of lactate transport via monocarboxylate transporter isoform 4 by carbonic anhydrase II. J. Membr. Biol. 234: 125-135. 20300744
Beckham, K.S., J.A. Potter, and S.E. Unkles. (2010). Formate-nitrite transporters: optimisation of expression, purification and analysis of prokaryotic and eukaryotic representatives. Protein Expr Purif 71: 184-189. 20006708
Behr, S., L. Fried, and K. Jung. (2014). Identification of a novel nutrient-sensing histidine kinase/response regulator network in Escherichia coli. J. Bacteriol. 196: 2023-2029. 24659770
Bellocchio, E.E., R.J. Reimer, R.T. Fremeau, Jr., and R.H. Edwards. (2000). Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter. Science 289: 957-960. 10938000
Benko, Z., C. Fenyvesvolgyi, M. Pesti, and M. Sipiczki. (2004). The transcription factor Pap1/Caf3 plays a central role in the determination of caffeine resistance in Schizosaccharomyces pombe. Mol. Genet. Genomics 271: 161-170. 14758541
Bennett, K.M., J. Liu, C. Hoelting, and J. Stoll. (2011). Expression and analysis of two novel rat organic cation transporter homologs, SLC22A17 and SLC22A23. Mol. Cell Biochem 352: 143-154. 21359964
Bernal J., Guadano-Ferraz A. and Morte B. (2015). Thyroid hormone transporters--functions and clinical implications. Nat Rev Endocrinol. 11(7):406-17. 25942657
Besse A., Peduzzi J., Rebuffat S. and Carre-Mlouka A. (2015). Antimicrobial peptides and proteins in the face of extremes: Lessons from archaeocins. Biochimie. 118:344-55. 26092421
Bhaskar, B.V., T.M. Babu, N.V. Reddy, and W. Rajendra. (2016). Homology modeling, molecular dynamics, and virtual screening of NorA efflux pump inhibitors of Staphylococcus aureus. Drug Des Devel Ther 10: 3237-3252. 27757014
Bianco, M.V., F.C. Blanco, B. Imperiale, M.A. Forrellad, R.V. Rocha, L.I. Klepp, A.A. Cataldi, N. Morcillo, and F. Bigi. (2011). Role of P27 -P55 operon from Mycobacterium tuberculosis in the resistance to toxic compounds. BMC Infect Dis 11: 195. 21762531
Bleuel, C., Grosse, C., Taudte, N., Scherer, J., Wesenberg, D., Krauss, G.J., Nies, D.H., and Grass, G. (2005). TolC is involved in enterobactin efflux across the outer membrane of Escherichia coli. J. Bacteriol. 187: 6701-6707. 16166532
Boccone, L., S. Mariotti, V. Dessì, D. Pruna, A. Meloni, and G. Loudianos. (2010). Allan-Herndon-Dudley syndrome (AHDS) caused by a novel SLC16A2 gene mutation showing severe neurologic features and unexpectedly low TRH-stimulated serum TSH. Eur J Med Genet 53: 392-395. 20713192
Bodoy, S., L. Martin, A. Zorzano, M. Palacín, R. Estévez, and J. Bertran. (2005). Identification of LAT4, a novel amino acid transporter with system L activity. J. Biol. Chem. 280: 12002-12011. 15659399
Bohn, C. and P. Bouloc. (1998). The Escherichia coli cmlA gene encodes the multidrug efflux pump Cmr/MdfA and is responsible for isopropyl-β-D-thiogalactopyranoside exclusion and spectinomycin sensitivity. J. Bacteriol. 180: 6072-6075. 9811673
Boles, E. and C.P. Hollenberg. (1997). The molecular genetics of hexose transport in yeasts. FEMS Microbiol. Rev. 21: 85-111. 9299703
Boorer, K.J., D.D. Loo, and E.M. Wright. (1994). Steady-state and presteady-state kinetics of the H+/hexose cotransporter (STP1) from Arabidopsis thaliana expressed in Xenopus oocytes. J. Biol. Chem. 269: 20417-20424. 8051137
Bossuyt, X., M. Müller, B. Hagenbuch, and P.J. Meier. (1996). Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver. J. Pharmacol. Exper. Therapeutics 276: 891-896. 8786566
Bost, S., F. Silva, and D. Belin. (1999). Transcriptional activation of ydeA, which encodes a member of the major facilitator superfamily, interferes with arabinose accumulation and induction of the Escherichia coli arabinose PBAD promoter. J. Bacteriol. 181: 2185-2191. 10094697
Bozdag, G.O., I. Uluisik, G.S. Gulculer, H.C. Karakaya, and A. Koc. (2011). Roles of ATR1 paralogs YMR279c and YOR378w in boron stress tolerance. Biochem. Biophys. Res. Commun. 409: 748-751. 21621519
Brandenstein, L., M. Schweizer, J. Sedlacik, J. Fiehler, and S. Storch. (2015). Lysosomal dysfunction and impaired autophagy in a novel mouse model deficient for the lysosomal membrane protein Cln7. Hum Mol Genet. [Epub: Ahead of Print] 26681805
Brickman, T.J. and S.K. Armstrong. (2005). Bordetella AlcS transporter functions in alcaligin siderophore export and is central to inducer sensing in positive regulation of alcaligin system gene expression. J. Bacteriol. 187: 3650-3661. 15901687
Brignone, M.S., A. Lanciotti, S. Camerini, C. De Nuccio, T.C. Petrucci, S. Visentin, and E. Ambrosini. (2015). MLC1 protein: a likely link between leukodystrophies and brain channelopathies. Front Cell Neurosci 9: 66. 25883547
Brown, M.G., E.H. Mitchell, and D.L. Balkwill. (2008). Tet 42, a novel tetracycline resistance determinant isolated from deep terrestrial subsurface bacteria. Antimicrob. Agents Chemother. 52: 4518-4521. 18809935
Bukhari, F.J., H. Moradi, P. Gollapudi, H. Ju Kim, N.D. Vaziri, and H.M. Said. (2011). Effect of chronic kidney disease on the expression of thiamin and folic acid transporters. Nephrol Dial Transplant 26: 2137-2144. 21149507
Buyse, M., S.V. Sitaraman, X. Liu, A. Bado, and D. Merlin. (2002). Luminal leptin enhances CD147/MCT-1-mediated uptake of butyrate in the human intestinal cell line Caco2-BBE. J. Biol. Chem. 277: 28182-28190. 12034734
Cai, H., M. Hauser, F. Naider, and J.M. Becker. (2007). Differential regulation and substrate preferences in two peptide transporters of Saccharomyces cerevisiae. Eukaryot. Cell. 6: 1805-1813. 17693598
Callewaert, B.L., A. Willaert, W.S. Kerstjens-Frederikse, J. De Backer, K. Devriendt, B. Albrecht, M.A. Ramos-Arroyo, M. Doco-Fenzy, R.C. Hennekam, R.E. Pyeritz, O.N. Krogmann, G. Gillessen-kaesbach, E.L. Wakeling, S. Nik-zainal, C. Francannet, P. Mauran, C. Booth, M. Barrow, R. Dekens, B.L. Loeys, P.J. Coucke, and A.M. De Paepe. (2008). Arterial tortuosity syndrome: clinical and molecular findings in 12 newly identified families. Hum Mutat 29(1): 150-158. 17935213
Cannon, R.D., F.J. Fischer, K. Niimi, M. Niimi, and M. Arisawa. (1998). Drug pumping mechanisms in Candida albicans. Nippon Ishinkin Gakkai Zasshi 39: 73-78. 9580031
Cao, C., E.K. Pressman, E.M. Cooper, R. Guillet, M. Westerman, and K.O. O'Brien. (2014). Placental heme receptor LRP1 correlates with the heme exporter FLVCR1 and neonatal iron status. Reproduction 148: 295-302. 24947444
Carayannopoulos, M.O., A. Schlein, A. Wyman, M. Chi, C. Keembiyehetty, and K.H. Moley. (2004). GLUT9 is differentially expressed and targeted in the preimplantation embryo. Endocrinology 145: 1435-1443. 14657010
Carayannopoulos, M.O., M.M. Chi, Y. Cui, J.M. Pingsterhaus, R.A. McKnight, M. Mueckler, S.U. Devaskar, and K.H. Moley. (2000). GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocyst. Proc. Natl. Acad. Sci. USA 97: 7313-7318. 10860996
Carolé, S., S. Pichoff, and J.P. Bouché. (1999). Escherichia coli gene ydeA encodes a major facilitator pump which exports L-arabinose and isopropyl-β-D-thiogalactopyranoside. J. Bacteriol. 181: 5123-5125. 10438792
Carter, E.L., L. Jager, L. Gardner, C.C. Hall, S. Willis, and J.M. Green. (2007). Escherichia coli abg genes enable uptake and cleavage of the folate catabolite p-aminobenzoyl-glutamate. J. Bacteriol. 189: 3329-3334. 17307853
Cartier, E.A., L.A. Parra, T.B. Baust, M. Quiroz, G. Salazar, V. Faundez, L. Egaña, and G.E. Torres. (2010). A biochemical and functional protein complex involving dopamine synthesis and transport into synaptic vesicles. J. Biol. Chem. 285: 1957-1966. 19903816
Cecchetto, G., S. Amillis, G. Diallinas, C. Scazzocchio, and C. Drevet. (2004). The AzgA purine transporter of Aspergillus nidulans: characterization of a protein belonging to a new phylogenetic cluster. J. Biol. Chem. 279: 3132-3141. 14597637
Cesareo, R., M. Iozzino, D. Alva, C. Napolitano, B. De Rosa, S. Contini, L. Mallardo, A. Lauria, G. Reda, and A. Orsini. (2007). Evidence based medicine and effective interventions of pharmacological therapy for the prevention of osteoporotic fractures. Minerva Endocrinol 32: 275-295. 18091664
Chahine, S. and M.J. O'Donnell. (2010). Effects of acute or chronic exposure to dietary organic anions on secretion of methotrexate and salicylate by Malpighian tubules of Drosophila melanogaster larvae. Arch Insect Biochem Physiol 73: 128-147. 20077573
Chahine, S., A. Campos, and M.J. O''Donnell. (2012). Genetic knockdown of a single organic anion transporter alters the expression of functionally related genes in Malpighian tubules of Drosophila melanogaster. J Exp Biol 215: 2601-2610. 22786636
Chahine, S., S. Seabrooke, and M.J. O''Donnell. (2012). Effects of genetic knock-down of organic anion transporter genes on secretion of fluorescent organic ions by Malpighian tubules of Drosophila melanogaster. Arch Insect Biochem Physiol 81: 228-240. 22972675
Chaillou, S., Y.C. Bor, C.A. Batt, P.W. Postma, and P.H. Pouwels. (1998). Molecular cloning and functional expression in Lactobacillus plantarum 80 of xylT, encoding the D-xylose-H+ symporter of Lactobacillus brevis. Appl. Environ. Microbiol. 64: 4720-4728. 9835554
Chang, H.-K. and G.J. Zylstra. (1999). Characterization of the phthalate permease OphD from Burkholderia cepacia ATCC 17616. J. Bacteriol. 181: 6197-6199. 10498738
Chang, Y.C., M.J. Tsai, Y.W. Huang, T.C. Chung, and T.C. Yang. (2011). SmQnrR, a DeoR-type transcriptional regulator, negatively regulates the expression of Smqnr and SmtcrA in Stenotrophomonas maltophilia. J Antimicrob Chemother 66: 1024-1028. 21393212
Chardwiriyapreecha, S., M. Shimazu, T. Morita, T. Sekito, K. Akiyama, K. Takegawa, and Y. Kakinuma. (2008). Identification of the fnx1(+) and fnx2(+) genes for vacuolar amino acid transporters in Schizosaccharomyces pombe. FEBS Lett. 582: 2225-2230. 18503766
Chaudhary, N., I. Kumari, P. Sandhu, M. Ahmed, and Y. Akhter. (2016). Proteome scale census of major facilitator superfamily transporters in Trichoderma reesei using protein sequence and structure based classification enhanced ranking. Gene. [Epub: Ahead of Print] 27041239
Chaudhary, N., P. Sandhu, M. Ahmed, and Y. Akhter. (2016). Structural basis of transport function in major facilitator superfamily protein from Trichoderma harzianum. Int J Biol Macromol. [Epub: Ahead of Print] 27816530
Chen, D.E., S. Podell, J.D. Sauer, M.S. Swanson, and M.H. Saier. (2008). The phagosomal nutrient transporter (Pht) family. Microbiology. 154: 42-53. 18174124
Chen, S.Y., C.J. Pan, K. Nandigama, B.C. Mansfield, S.V. Ambudkar, and J.Y. Chou. (2008). The glucose-6-phosphate transporter is a phosphate-linked antiporter deficient in glycogen storage disease type Ib and Ic. FASEB J. 22: 2206-2213. 18337460
Cheng, Q. and J.T. Park. (2002). Substrate specificity of the AmpG permease required for recycling of cell wall anhydro-muropeptides. J. Bacteriol. 184: 6434-6436. 12426329
Cho, Y.-H., E.-J. Kim, H.-J. Chung, J.-H. Choi, K.F. Chater, B.-E. Ahn, J.-H. Shin, and Y.-H. Roe. (2003). The pqrAB operon is responsible for paraquat resistance in Streptomyces coelicolor. J. Bacteriol. 185: 6756-6763. 14617639
Chou, J.Y. and B.C. Mansfield. (2014). The SLC37 family of sugar-phosphate/phosphate exchangers. Curr Top Membr 73: 357-382. 24745989
Christensen, M., T. Borza, G. Dandanell, A.-M. Gilles, O. Barzu, R.A. Kelln, and J. Neuhard. (2003). Regulation of expression of the 2-deoxy-D-ribose utilization regulon, deoQKPX, from Salmonella enterica serovar typhimurium. J. Bacteriol. 185: 6042-6050. 14526015
Clark, T.J., C. Momany, and E.L. Neidle. (2002). The benPK operon, proposed to play a role in transport, is part of a regulon for benzoate catabolism in Acinetobacter sp. strain ADP1. Microbiology 148: 1213-1223. 11932465
Clegg, S., F. Yu, L. Griffiths, and J.A. Cole. (2002). The roles of the polytopic membrane proteins NarK, NarU and NirC in Escherichia coli K-12: two nitrate and three nitrite transporters. Mol. Microbiol. 44: 143-155. 11967075
Clegg, S.J., W. Jia, and J.A. Cole. (2006). Role of the Escherichia coli nitrate transport protein, NarU, in survival during severe nutrient starvation and slow growth. Microbiology 152: 2091-2100. 16804183
Cliburn, R.A., A.R. Dunn, K.A. Stout, C.A. Hoffman, K.M. Lohr, A.I. Bernstein, E.J. Winokur, J. Burkett, Y. Shmitz, W.M. Caudle, and G.W. Miller. (2016). Immunochemical localization of vesicular monoamine transporter 2 (VMAT2) in mouse brain. J Chem Neuroanat. [Epub: Ahead of Print] 27836486
Collier, L.S., N.N. Nichols, and E.L. Neidle. (1997). benK encodes a hydrophobic permease-like protein involved in benzoate degradation by Acinetobacter sp. strain ADP1. J. Bacteriol. 179: 5943-5946. 9294456
Condemine, G. (2000). Characterization of SotA and SotB, two Erwinia chrysanthemi proteins which modify isopropyl-β-D-thiogalactopyranoside and lactose induction of the Escherichia coli lac promoter. J. Bacteriol. 182: 1340-1345. 10671456
Cooper, G.J., B. Leighton, A.C. Willis, and A.J. Day. (1989). The amylin superfamily: a novel grouping of biologically active polypeptides related to the insulin A-chain. Prog Growth Factor Res 1: 99-105. 2491258
Coucke, P.J., A. Willaert, M.W. Wessels, B. Callewaert, N. Zoppi, J. De Backer, J.E. Fox, G.M. Mancini, M. Kambouris, R. Gardella, F. Facchetti, P.J. Willems, R. Forsyth, H.C. Dietz, S. Barlati, M. Colombi, B. Loeys, and A. De Paepe. (2006). Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome. Nat. Genet. 38: 452-457. 16550171
Courville, P., M. Quick, and R.J. Reimer. (2010). Structure-function studies of the SLC17 transporter sialin identify crucial residues and substrate-induced conformational changes. J. Biol. Chem. 285: 19316-19323. 20424173
Crouch, M.L., M. Castor, J.E. Karlinsey, T. Kalhorn, and F.C. Fang (2008). Biosynthesis and IroC-dependent export of the siderophore salmochelin are essential for virulence of Salmonella enterica serovar Typhimurium. Mol Microbiol 67: 971-983. 18194158
Cui, H., L. Li, W. Wang, J. Shen, Z. Yue, X. Zheng, X. Zuo, B. Liang, M. Gao, X. Fan, X. Yin, C. Shen, C. Yang, C. Zhang, X. Zhang, Y. Sheng, J. Gao, Z. Zhu, D. Lin, A. Zhang, Z. Wang, S. Liu, L. Sun, S. Yang, Y. Cui, and X. Zhang. (2014). Exome sequencing identifies SLC17A9 pathogenic gene in two Chinese pedigrees with disseminated superficial actinic porokeratosis. J Med Genet 51: 699-704. 25180256
Cuív, P.O., P. Clarke, D. Lynch, and M. O'Connell. (2004). Identification of rhtX and fptX, novel genes encoding proteins that show homology and function in the utilization of the siderophores rhizobactin 1021 by Sinorhizobium meliloti and pyochelin by Pseudomonas aeruginosa, respectively. J. Bacteriol. 186: 2996-3005. 15126460
Cunningham P. and Naftalin RJ. (2014). Reptation-induced coalescence of tunnels and cavities in Escherichia Coli XylE transporter conformers accounts for facilitated diffusion. J Membr Biol. 247(11):1161-79. 25163893
Cunningham, P., Afzal-Ahmed, I., and Naftalin, R.J. (2006). Docking studies show that D-glucose and quercetin slide through the transporter GLUT1. J. Biol. Chem. 281: 5797-5803. 16407180
Cura, A.J. and A. Carruthers. (2010). Acute modulation of sugar transport in brain capillary endothelial cell cultures during activation of the metabolic stress pathway. J. Biol. Chem. 285: 15430-15439. 20231288
Cushion, M.T., M.S. Collins, T. Sesterhenn, A. Porollo, A.K. Vadukoot, and E.J. Merino. (2016). Functional Characterization of Pneumocystis carinii Inositol Transporter 1. MBio 7:. 27965450
Czeredys, M., L. Samluk, K. Michalec, K. Tułodziecka, K. Skowronek, and K.A. Nałęcz. (2013). Caveolin-1 - a novel interacting partner of organic cation/carnitine transporter (octn2): effect of protein kinase C on this interaction in rat astrocytes. PLoS One 8: e82105. 24349196
D'Argenio, D.A., A. Segura, W.M. Coco, P.V. Bünz, and L.N. Ornston. (1999). The physiological contribution of Acinetobacter PcaK, a transport system that acts upon protocatechuate, can be masked by the overlapping specificity of VanK. J. Bacteriol. 181: 3505-3515. 10348864
Dahlin, A., E. Geier, S.L. Stocker, C.D. Cropp, E. Grigorenko, M. Bloomer, J. Siegenthaler, L. Xu, A.S. Basile, D.D. Tang-Liu, and K.M. Giacomini. (2013). Gene expression profiling of transporters in the solute carrier and ATP-binding cassette superfamilies in human eye substructures. Mol Pharm 10: 650-663. 23268600
Dang, S., L. Sun, Y. Huang, F. Lu, Y. Liu, H. Gong, J. Wang, and N. Yan. (2010). Structure of a fucose transporter in an outward-open conformation. Nature 467: 734-738. 20877283
Darley, P.I., J.A. Hellstern, J.I. Medina-Bellver, S. Marqués, B. Schink, and B. Philipp. (2007). Heterologous expression and identification of the genes involved in anaerobic degradation of 1,3-dihydroxybenzene (resorcinol) in Azoarcus anaerobius. J. Bacteriol. 189: 3824-3833. 17369298
Date, S.S., C.Y. Chen, Y. Chen, and M. Jansen. (2016). Experimentally optimized threading structures of the proton-coupled folate transporter. FEBS Open Bio 6: 216-230. 27047750
De Zutter JK., Levine KB., Deng D. and Carruthers A. (2013). Sequence determinants of GLUT1 oligomerization: analysis by homology-scanning mutagenesis. J Biol Chem. 288(28):20734-44. 23720776
Deng, D., P. Sun, C. Yan, M. Ke, X. Jiang, L. Xiong, W. Ren, K. Hirata, M. Yamamoto, S. Fan, and N. Yan. (2015). Molecular basis of ligand recognition and transport by glucose transporters. Nature 526: 391-396. 26176916
Di Daniel, E., M.H. Mok, E. Mead, C. Mutinelli, E. Zambello, L.L. Caberlotto, T.J. Pell, C.J. Langmead, A.J. Shah, G. Duddy, J.N. Kew, and P.R. Maycox. (2009). Evaluation of expression and function of the H+/myo-inositol transporter HMIT. BMC Cell Biol 10: 54. 19607714
Díaz, E., A. Ferrández, and J.L. García. (1998). Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12. J. Bacteriol. 180: 2915-2923. 9603882
Dietvorst, J., J. Londesborough, and H.Y. Steensma. (2005). Maltotriose utilization in lager yeast strains: MTT1 encodes a maltotriose transporter. Yeast 22: 775-788. 16088872
Dietvorst, J., K. Karhumaa, M.C. Kielland-Brandt, and A. Brandt. (2010). Amino acid residues involved in ligand preference of the Snf3 transporter-like sensor in Saccharomyces cerevisiae. Yeast 27: 131-138. 20014043
Diezemann, A. and E. Boles. (2003). Functional characterization of the Frt1 sugar transporter and of fructose uptake in Kluyveromyces lactis. Curr. Genet. 43: 281-288. 12677461
Divito, C.B., K. Steece-Collier, D.T. Case, S.P. Williams, J.A. Stancati, L. Zhi, M.E. Rubio, C.E. Sortwell, T.J. Collier, D. Sulzer, R.H. Edwards, H. Zhang, and R.P. Seal. (2015). Loss of VGLUT3 Produces Circadian-Dependent Hyperdopaminergia and Ameliorates Motor Dysfunction and l-Dopa-Mediated Dyskinesias in a Model of Parkinson''s Disease. J. Neurosci. 35: 14983-14999. 26558771
Doege, H., A. Schürmann, G. Bahrenberg, A. Brauers, and H.G. Joost. (2000). GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity. J. Biol. Chem. 275: 16275-16280. 10821868
Dowhan, W. and M. Bogdanov. (2011). Lipid-protein interactions as determinants of membrane protein structure and function. Biochem Soc Trans 39: 767-774. 21599647
Duan, P., J. Wu, and G. You. (2011). Mutational analysis of the role of GXXXG motif in the function of human organic anion transporter 1 (hOAT1). Int J Biochem Mol Biol 2: 1-7. 21340049
Duffy, S.P., J. Shing, P. Saraon, L.C. Berger, M.V. Eiden, A. Wilde, and C.S. Tailor. (2010). The Fowler syndrome-associated protein FLVCR2 is an importer of heme. Mol. Cell Biol. 30: 5318-5324. 20823265
Eames, M. and T. Kortemme. (2012). Cost-benefit tradeoffs in engineered lac operons. Science 336: 911-915. 22605776
Egenberger B., Gorboulev V., Keller T., Gorbunov D., Gottlieb N., Geiger D., Mueller TD. and Koepsell H. (2012). A substrate binding hinge domain is critical for transport-related structural changes of organic cation transporter 1. J Biol Chem. 287(37):31561-73. 22810231
Ekici, S., H. Yang, H.G. Koch, and F. Daldal. (2012). Novel transporter required for biogenesis of cbb3-type cytochrome c oxidase in Rhodobacter capsulatus. MBio 3:. 22294680
Elkins, C.A. and D.C. Savage. (1998). Identification of genes encoding conjugated bile salt hydrolase and transport in Lactobacillus johnsonii 100-100. J. Bacteriol. 180: 4344-4349. 9721268
Elkins, C.A. and L.B. Mullis. (2006). Mammalian steroid hormones are substrates for the major RND- and MFS-type tripartite multidrug efflux pumps of Escherichia coli. J. Bacteriol. 188: 1191-1195. 16428427
Enomoto, A., H. Kumura, A. Chairoungdua, Y. Shigeta, P. Jutabha, S.H. Cha, M. Hosoyamada, M. Takeda, T. Sekine, T. Igarashi, H. Matsuo, Y. Kikuchi, T. Oda, K. Ichida, T. Hosoya, K. Shimokata, T. Niwa, Y. Kanai, and H. Endou. (2002). Molecular identification of a renal urate-anion exchanger that regulates blood urate levels. Nature 417: 447-450. 12024214
Enomoto, A., M.F. Wempe, H. Tsuchida, H.J. Shin, S.H. Cha, N. Anzai, A. Goto, A. Sakamoto, T. Niwa, Y. Kanai, M.W. Anders, and H. Endou. (2002). Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition. J. Biol. Chem. 277: 36262-36271. 12089149
Eraly, S.A., B.A. Hamilton, and S.K. Nigam. (2003). Organic anion and cation transporters occur in pairs of similar and similarly expressed genes. Biochem. Biophys. Res. Commun. 300: 333-342. 12504088
Eraly, S.A., J.C. Monte, and S.K. Nigam. (2004). Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters. Physiol Genomics 18: 12-24. 15054140
Eraly, S.A., K.T. Bush, R.V. Sampogna, V. Bhatnagar, and S.K. Nigam. (2003). The molecular biology of organic anion transporters: from DNA to FDA? Mol. Pharmacol. in press. 12920404
Eraly, S.A., V. Vallon, T. Rieg, J.A. Gangoiti, W.R. Wikoff, G. Siuzdak, B.A. Barshop, and S.K. Nigam. (2008). Multiple organic anion transporters contribute to net renal excretion of uric acid. Physiol Genomics 33: 180-192. 18270321
Erb, R.W., K.N. Timmis, and D.H. Pieper DH. (1998). Characterization of a gene cluster from Ralstonia eutropha JMP134 encoding metabolism of 4-methylmuconolactone. Gene. 206: 53-62. 9461415
Erickson, J.D., M.K. Schafer, T.I. Bonner, L.E. Eiden, and E. Weihe. (1996). Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter. Proc. Natl. Acad. Sci. USA 93: 5166-5171. 8643547
Ernst, C.M., P. Staubitz, N.N. Mishra, S.J. Yang, G. Hornig, H. Kalbacher, A.S. Bayer, D. Kraus, and A. Peschel. (2009). The bacterial defensin resistance protein MprF consists of separable domains for lipid lysinylation and antimicrobial peptide repulsion. PLoS Pathog 5: e1000660. 19915718
Ernst, C.M., S. Kuhn, C.J. Slavetinsky, B. Krismer, S. Heilbronner, C. Gekeler, D. Kraus, S. Wagner, and A. Peschel. (2015). The lipid-modifying multiple Peptide resistance factor is an oligomer consisting of distinct interacting synthase and flippase subunits. MBio 6:. 25626904
Evers, M.E., H. Trip, M.A. van den Berg, R.A. Bovenberg, and A.J. Driessen. (2004). Compartmentalization and transport in β-lactam antibiotics biosynthesis. Adv Biochem Eng Biotechnol 88: 111-135. 15719554
Fàbrega, A., R.G. Martin, J.L. Rosner, M.M. Tavio, and J. Vila. (2010). Constitutive SoxS expression in a fluoroquinolone-resistant strain with a truncated SoxR protein and identification of a new member of the marA-soxS-rob regulon, mdtG. Antimicrob. Agents Chemother. 54: 1218-1225. 20008776
Fang H., Wu Y., Guo J., Rong J., Ma L., Zhao Z., Zuo D. and Peng S. (2012). T-2 toxin induces apoptosis in differentiated murine embryonic stem cells through reactive oxygen species-mediated mitochondrial pathway. Apoptosis. 17(8):895-907. 22614820
Farrow, M.F. and E.J. Rubin. (2008). Function of a mycobacterial major facilitator superfamily pump requires a membrane-associated lipoprotein. J. Bacteriol. 190: 1783-1791. 18156250
Farsi, Z., J. Preobraschenski, G. van den Bogaart, D. Riedel, R. Jahn, and A. Woehler. (2016). Single-vesicle imaging reveals different transport mechanisms between glutamatergic and GABAergic vesicles. Science 351: 981-984. 26912364
Farwick, A., S. Bruder, V. Schadeweg, M. Oreb, and E. Boles. (2014). Engineering of yeast hexose transporters to transport D-xylose without inhibition by D-glucose. Proc. Natl. Acad. Sci. USA 111: 5159-5164. 24706835
Fernandez-Aguado M., Martin JF., Rodriguez-Castro R., Garcia-Estrada C., Albillos SM., Teijeira F. and Ullan RV. (2014). New insights into the isopenicillin N transport in Penicillium chrysogenum. Metab Eng. 22:89-103. 24480587
Fernández-Aguado, M., R.V. Ullán, F. Teijeira, R. Rodríguez-Castro, and J.F. Martín. (2013). The transport of phenylacetic acid across the peroxisomal membrane is mediated by the PaaT protein in Penicillium chrysogenum. Appl. Microbiol. Biotechnol. 97: 3073-3084. 23053082
Ferreira, C., F. van Voorst, A. Martins, L. Neves, R. Oliveira, M.C. Kielland-Brandt, C. Lucas, and A. Brandt. (2005). A member of the sugar transporter family, Stl1p is the glycerol/H+ symporter in Saccharomyces cerevisiae. Mol. Biol. Cell 16: 2068-2076. 15703210
Ferreira, M.J. and I. Sá-Nogueira. (2010). A multitask ATPase serving different ABC-type sugar importers in Bacillus subtilis. J. Bacteriol. 192: 5312-5318. 20693325
Filippo, C.A., O. Ardon, and N. Longo. (2011). Glycosylation of the OCTN2 carnitine transporter: study of natural mutations identified in patients with primary carnitine deficiency. Biochim. Biophys. Acta. 1812: 312-320. 21126579
Fiorentino, G., R. Ronca, R. Cannio, M. Rossi, and S. Bartolucci. (2007). MarR-like transcriptional regulator involved in detoxification of aromatic compounds in Sulfolobus solfataricus. J. Bacteriol. 189: 7351-7360. 17675388
Fisel P., Stuhler V., Bedke J., Winter S., Rausch S., Hennenlotter J., Nies AT., Stenzl A., Scharpf M., Fend F., Kruck S., Schwab M. and Schaeffeler E. (2015). MCT4 surpasses the prognostic relevance of the ancillary protein CD147 in clear cell renal cell carcinoma. Oncotarget. 6(31):30615-27. 26384346
Floyd, J.L., K.P. Smith, S.H. Kumar, J.T. Floyd, and M.F. Varela. (2010). LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus. Antimicrob. Agents Chemother. 54: 5406-5412. 20855745
Fluman, N., D. Cohen-Karni, T. Weiss, and E. Bibi. (2009). A promiscuous conformational switch in the secondary multidrug transporter MdfA. J. Biol. Chem. 284: 32296-32304. 19808670
Fomenko, D.E., A.Z. Metlitskaya, J. Péduzzi, C. Goulard, G.S. Katrukha, L.V. Gening, S. Rebuffat, and I.A. Khmel. (2003). Microcin C51 plasmid genes: possible source of horizontal gene transfer. Antimicrob. Agents Chemother. 47: 2868-2874. 12936987
Fonseca, M.V., J.D. Sauer, S. Crepin, B. Byrne, and M.S. Swanson. (2014). The phtC-phtD locus equips Legionella pneumophila for thymidine salvage and replication in macrophages. Infect. Immun. 82: 720-730. 24478086
Forment, J.V., M. Flipphi, D. Ramón, L. Ventura, and A.P. Maccabe. (2006). Identification of the mstE gene encoding a glucose-inducible, low affinity glucose transporter in Aspergillus nidulans. J. Biol. Chem. 281: 8339-8346. 16418173
Franza, T., B. Mahé, and D. Expert. (2005). Erwinia chrysanthemi requires a second iron transport route dependent of the siderophore achromobactin for extracellular growth and plant infection. Mol. Microbiol. 55: 261-275. 15612933
Friesema, E.C.H., S. Ganguly, A. Abdalla, J.E. Manning Fox, A.P. Halestrap, and T.J. Visser. (2003). Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. J. Biol. Chem. 278: 40128-40135. 12871948
Frohlich, K.M. and J.P. Audia. (2013). Dual mechanisms of metabolite acquisition by the obligate intracytosolic pathogen Rickettsia prowazekii reveal novel aspects of triose phosphate transport. J. Bacteriol. 195: 3752-3760. 23772074
Fu, D. and P.C. Maloney. (1998). Structure-function relationships in OxlT, the oxalate/formate transporter of Oxalobacter formigenes. Topological features of transmembrane helix 11 as visualized by site-directed fluorescent labeling. J. Biol. Chem. 273: 17962-17967. 9651403
Fu, D., R.I. Sarker, K. Abe, E. Bolton, and P.C. Maloney. (2001). Structure/function relationships in OxlT, the oxalate-formate transporter of oxalobacter formigenes. Assignment of transmembrane helix 11 to the translocation pathway. J. Biol. Chem. 276: 8753-8760. 11113128
Fukuda, M., H. Takeda, H.E. Kato, S. Doki, K. Ito, A.D. Maturana, R. Ishitani, and O. Nureki. (2015). Structural basis for dynamic mechanism of nitrate/nitrite antiport by NarK. Nat Commun 6: 7097. 25959928
Fukuhara, S., S. Simmons, S. Kawamura, A. Inoue, Y. Orba, T. Tokudome, Y. Sunden, Y. Arai, K. Moriwaki, J. Ishida, A. Uemura, H. Kiyonari, T. Abe, A. Fukamizu, M. Hirashima, H. Sawa, J. Aoki, M. Ishii, and N. Mochizuki. (2012). The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. J Clin Invest 122: 1416-1426. 22406534
Furrer, J.L., D.N. Sanders, I.G. Hook-Barnard, and M.A. McIntosh. (2002). Export of the siderophore enterobactin in Escherichia coli: involvement of a 43 kDa membrane exporter. Mol. Microbiol. 44: 1225-1234. 12068807
Gaballa, A., M. Cao, and J.D. Helmann. (2003). Two MerR homologues that affect copper induction of the Bacillus subtilis copZA operon. Microbiology 149: 3413-3421. 14663075
Galazka, J.M., C. Tian, W.T. Beeson, B. Martinez, N.L. Glass, and J.H. Cate. (2010). Cellodextrin transport in yeast for improved biofuel production. Science 330: 84-86. 20829451
Ganapathy, M.E., W. Huang, D.P. Rajan, A.L. Carter, M. Sugawara, K. Iseki, F.H. Leibach, and V. Ganapathy. (2000). β-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. J. Biol. Chem. 275: 1699-1707. 10636865
Garcia, D.L. and J.P. Dillard. (2008). Mutations in ampG or ampD affect peptidoglycan fragment release from Neisseria gonorrhoeae. J. Bacteriol. 190: 3799-3807. 18390650
Garcia-Dominguez, M., L. Lopez-Maury, F.J. Florencio, and J.C. Reyes. (2000). A gene cluster involved in metal homeostasis in the cyanobacterium Synechocystis sp. strain PCC 6803. J. Bacteriol. 182: 1507-1514. 10692354
Gerin, I., M. Veiga-da-Cunha, Y. Achouri, J.F. Collet, and E.V. Schaftingen. (1999). Sequence of a putative glucose 6-phosphate translocase, mutated in glycogen storage disease type Ib. Fed. Euro. Biochem. 419: 235-238. 9428641
Ghssein, G., C. Brutesco, L. Ouerdane, C. Fojcik, A. Izaute, S. Wang, C. Hajjar, R. Lobinski, D. Lemaire, P. Richaud, R. Voulhoux, A. Espaillat, F. Cava, D. Pignol, E. Borezée-Durant, and P. Arnoux. (2016). Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus. Science 352: 1105-1109. 27230378
Girin T., El-Kafafi el-S., Widiez T., Erban A., Hubberten HM., Kopka J., Hoefgen R., Gojon A. and Lepetit M. (2010). Identification of Arabidopsis mutants impaired in the systemic regulation of root nitrate uptake by the nitrogen status of the plant. Plant Physiol. 153(3):1250-60. 20448103
Goddard, A.D., J.W. Moir, D.J. Richardson, and S.J. Ferguson. (2008). Interdependence of two NarK domains in a fused nitrate/nitrite transporter. Mol. Microbiol. 70: 667-681. 18823285
Goffeau, A., J. Park, I.T. Paulsen, J.-L. Jonniaux, T. Dinh, P. Mordant, and M.H. Saier, Jr. (1997). Multidrug resistant transport proteins in yeast. Complete inventory and phylogenetic characterization of yeast open reading frames within the major facilitator superfamily. Yeast 13: 43-54. 9046086
Gonzalez, E., E. Flier, D. Molle, D. Accili, and T.E. McGraw. (2011). Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor. Proc. Natl. Acad. Sci. USA 108: 10162-10167. 21646544
González-Pasayo, R. and E. Martínez-Romero. (2000). Multiresistance genes of Rhizobium etli CFN42. Mol. Plant-Microbe Interact. 13: 572-577. 10796024
Gründemann, D., J. Babin-Ebell, F. Martel, N. Ording, A. Schmidt, and E. Schömig. (1997). Primary structure and functional expression of the apical organic cation transporter from kidney epithelial LLC-PK1 cells. J. Biol. Chem. 272: 10408-10413. 9099681
Gras, C., E. Herzog, G.C. Bellenchi, V. Bernard, P. Ravassard, M. Pohl, B. Gasnier, B. Giros, and S. El Mestikawy. (2002). A third vesicular glutamate transporter expressed by cholinergic and serotoninergic neurons. J. Neurosci. 22: 5442-5451. 12097496
Green, A.L., E.J. Anderson, and R.J. Brooker. (2000). A revised model for the structure and function of the lactose permease. J. Biol. Chem. 275: 23240-23246. 10807929
Griffith, J.K., M.E. Baker, D.A. Rouch, M.G.P. Page, R.A. Skurray, I.T. Paulsen, K.F. Chater, S.A. Baldwin, and P.J.F. Henderson. (1992). Membrane transport proteins: implications of sequence comparisons. Curr. Opin. Cell Biol. 4: 684-695. 1419050
Groeneweg S., Friesema EC., Kersseboom S., Klootwijk W., Visser WE., Peeters RP. and Visser TJ. (2014). The role of Arg445 and Asp498 in the human thyroid hormone transporter MCT8. Endocrinology. 155(2):618-26. 24265446
Gronskiy, S.V., N.P. Zakataeva, M.V. Vitushkina, L.R. Ptitsyn, I.B. Altman, A.E. Novikova, and V.A. Livshits. (2005). The yicM (nepI) gene of Escherichia coli encodes a major facilitator superfamily protein involved in efflux of purine ribonucleosides. FEMS Microbiol. Lett. 250: 39-47. 16040204
Großhennig, S., S.R. Schmidl, G. Schmeisky, J. Busse, and J. Stülke. (2013). Implication of glycerol and phospholipid transporters in Mycoplasma pneumoniae growth and virulence. Infect. Immun. 81: 896-904. 23297388
Gründling, A. and O. Schneewind. (2007). Genes required for glycolipid synthesis and lipoteichoic acid anchoring in Staphylococcus aureus. J. Bacteriol. 189: 2521-2530. 17209021
Guan, L., O. Mirza, G. Verner, S. Iwata, and H.R. Kaback. (2007). Structural determination of wild-type lactose permease. Proc. Natl. Acad. Sci. USA 104: 15294-15298. 17881559
Halestrap, A.P. (2013). Monocarboxylic acid transport. Compr Physiol 3: 1611-1643. 24265240
Hamacher, T., J. Becker, M. Gárdonyi, B. Hahn-Hägerdal, and E. Boles. (2002). Characterization of the xylose-transporting properties of yeast hexose transporters and their influence on xylose utilization. Microbiology 148: 2783-2788. 12213924
Hanschmann EM., Godoy JR., Berndt C., Hudemann C. and Lillig CH. (2013). Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling. Antioxid Redox Signal. 19(13):1539-605. 23397885
Harris, K.G. and C.B. Coyne. (2015). Unc93b Induces Apoptotic Cell Death and Is Cleaved by Host and Enteroviral Proteases. PLoS One 10: e0141383. 26509685
Harvat, E.M., Y.M. Zhang, C.V. Tran, Z. Zhang, M.W. Frank, C.O. Rock, and M.H. Saier, Jr. (2005). Lysophospholipid flipping across the Escherichia coli inner membrane catalyzed by a transporter (LplT) belonging to the major facilitator superfamily. J. Biol. Chem. 280: 12028-12034. 15661733
Hassan, K.A., A.J. Brzoska, N.L. Wilson, B.A. Eijkelkamp, M.H. Brown, and I.T. Paulsen. (2011). Roles of DHA2 family transporters in drug resistance and iron homeostasis in Acinetobacter spp. J. Mol. Microbiol. Biotechnol. 20: 116-124. 21430390
Hassan, K.A., R.A. Skurray, and M.H. Brown. (2007). Transmembrane helix 12 of the Staphylococcus aureus multidrug transporter QacA lines the bivalent cationic drug binding pocket. J. Bacteriol. 189: 9131-9134. 17951386
Hawkins, A.C. and C.S. Harwood. (2002). Chemotaxis of Ralstonia eutropha JMP134(pJP4) to the herbicide 2,4-dichlorophenoxyacetate. Appl. Environ. Microbiol. 68: 968-972. 11823246
Hayashi, M., K. Tabata, M. Yagasaki, and Y. Yonetani. (2010). Effect of multidrug-efflux transporter genes on dipeptide resistance and overproduction in Escherichia coli. FEMS Microbiol. Lett. 304: 12-19. 20067529
Hayashi, T., Y. Tanaka, N. Sakai, U. Okada, M. Yao, N. Watanabe, T. Tamura, and I. Tanaka. (2013). SCO4008, a putative TetR transcriptional repressor from streptomyces coelicolor A3(2), regulates transcription of sco4007 by multidrug recognition. J. Mol. Biol. 425: 3289-3300. 23831227
Heiland, S., N. Radovanovic, M. Höfer, J. Winderickx, and H. Lichtenberg. (2000). Multiple hexose transporters of Schizosaccharomyces pombe. J. Bacteriol. 182: 2153-2162. 10735857
Hellborg, L., M. Woolfit, M. Arthursson-Hellborg, and J. Piskur. (2008). Complex evolution of the DAL5 transporter family. BMC Genomics 9: 164. 18405355
Hernández-Montalvo, V., F. Valle, F. Bolivar, and G. Gosset. (2001). Characterization of sugar mixtures utilization by an Escherichia coli mutant devoid of the phosphotransferase system. Appl. Microbiol. Biotechnol. 57: 186-191. 11693918
Heuel, H., S. Turgut, K. Schmid, and J.W. Lengeler. (1997). Substrate recognition domains as revealed by active hybrids between D-arabinitol and ribitol transporters from Klebsiella pneumoniae. J. Bacteriol. 179: 6014-6019. 9324246
Heymann, J.A.W., R. Sarker, T. Hirai, D. Shi, J.L.S. Milne, P.C. Maloney, and S. Subramaniam. (2001). Projection structure and molecular architecture of OxlT, a bacterial membrane transporter. EMBO J. 20: 4408-4413. 11500368
Higgins, C.F. (2007). Multiple molecular mechanisms for multidrug resistance transporters. Nature 446: 749-757. 17429392
Hirabayashi, Y., K.H. Nomura, and K. Nomura. (2013). The acetyl-CoA transporter family SLC33. Mol Aspects Med 34: 586-589. 23506891
Hirai, T., J.A.W. Heymann, D. Shi, R. Sarker, P.C. Maloney, and S. Subramaniam. (2002). Three-dimensional structure of a bacterial oxalate transporter. Nature Struct. Biol. 9: 597-600. 12118242
Hirai, T., J.A.W. Heymann, P.C. Maloney, and S. Subramaniam. (2003). A structural model for 12-helix transporters belonging to the major facilitator superfamily. J. Bacteriol. 185: 1712-1718. 12591890
Hisano, Y., N. Kobayashi, A. Kawahara, A. Yamaguchi, and T. Nishi. (2011). The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720. J. Biol. Chem. 286: 1758-1766. 21084291
Hopkins AP., Hawkhead JA. and Thomas GH. (2013). Transport and catabolism of the sialic acids N-glycolylneuraminic acid and 3-keto-3-deoxy-D-glycero-D-galactonononic acid by Escherichia coli K-12. FEMS Microbiol Lett. 347(1):14-22. 23848303
Horiba, N., S. Masuda, A. Takeuchi, D. Takeuchi, M. Okuda, and K. Inui. (2003). Cloning and characterization of a novel Na+-dependent glucose transporter (NaGLT1) in rat kidney. J. Biol. Chem. 278: 14669-14676. 12590146
Hoshino, H. (2012). Cellular Factors Involved in HTLV-1 Entry and Pathogenicit. Front Microbiol 3: 222. 22737146
Hosoyamada, M., K. Ichida, A. Enomoto, T. Hosoya, and H. Endou. (2004). Function and localization of urate transporter 1 in mouse kidney. J Am Soc Nephrol 15: 261-268. 14747372
Hosoyamada, M., T. Sekine, Y. Kanai, and H. Endou. (1999). Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. Am. J. Physiol. 276: F122-128. 9887087
Hu, Y., V. Fernández, and L. Ma. (2014). Nitrate transporters in leaves and their potential roles in foliar uptake of nitrogen dioxide. Front Plant Sci 5: 360. 25126090
Huang, H.T., J.H. Leu, P.Y. Huang, and L.L. Chen. (2012). A putative cell surface receptor for white spot syndrome virus is a member of a transporter superfamily. PLoS One 7: e33216. 22427993
Huang, Y., M.J. Lemieux, J. Song, M. Auer, and D.N. Wang. (2003). Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli. Science 301: 616-620. 12893936
Hvorup, R.N. and M.H. Saier, Jr. (2002). Sequence similarity between the channel-forming domains of voltage-gated ion channel proteins and the C-terminal domains of secondary carriers of the major facilitator superfamily. Microbiology 148: 3760-3762. 12480878
Igarashi, K. and K. Kashiwagi. (2010). Characteristics of cellular polyamine transport in prokaryotes and eukaryotes. Plant Physiol. Biochem 48: 506-512. 20159658
Ikeda, M., Y. Mizuno, S. Awane, M. Hayashi, S. Mitsuhashi, and S. Takeno. (2011). Identification and application of a different glucose uptake system that functions as an alternative to the phosphotransferase system in Corynebacterium glutamicum. Appl. Microbiol. Biotechnol. 90: 1443-1451. 21452034
Inaoka, T., K. Takahashi, M. Ohnishi-Kameyama, M. Yoshida,and K. Ochi. (2003). Guanine nucleotides guanosine 5'-diphosphate 3'-diphosphate and GTP co-operatively regulate the production of an antibiotic bacilysin in Bacillus subtilis. J. Biol. Chem. 278: 2169-2176. 12372825
Ingoglia F., Visigalli R., Rotoli BM., Barilli A., Riccardi B., Puccini P. and Dall'Asta V. (2016). Functional activity of L-carnitine transporters in human airway epithelial cells. Biochim Biophys Acta. 1858(2):210-9. 26607009
Inoue, K., Y. Nakai, S. Ueda, S. Kamigaso, K.Y. Ohta, M. Hatakeyama, Y. Hayashi, M. Otagiri, and H. Yuasa. (2008). Functional characterization of PCFT/HCP1 as the molecular entity of the carrier-mediated intestinal folate transport system in the rat model. Am. J. Physiol. Gastrointest. Liver Physiol. 294: G660-668. 18174275
Iserovich, P., D. Wang, L. Ma, H. Yang, F.A. Zuniga, J.M. Pascual, K. Kuang, D.C. De Vivo, and J. Fischbarg. (2002). Changes in glucose transport and water permeability resulting from the T310I pathogenic mutation in Glut1 are consistent with two transport channels per monomer. J. Biol. Chem. 277: 30991-30997. 12032147
Isnardi, I., Y.S. Ng, I. Srdanovic, R. Motaghedi, S. Rudchenko, H. von Bernuth, S.Y. Zhang, A. Puel, E. Jouanguy, C. Picard, B.Z. Garty, Y. Camcioglu, R. Doffinger, D. Kumararatne, G. Davies, J.I. Gallin, S. Haraguchi, N.K. Day, J.L. Casanova, and E. Meffre. (2008). IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans. Immunity 29: 746-757. 19006693
Iwabuchi, T., and S. Harayama. (1997). Biochemical and genetic characterization of 2-carboxybenzaldehyde dehydrogenase, an enzyme involved in phenanthrene degradation by Nocardioides sp. strain KP7. J. Bacteriol. 179: 6488-6494. 9335300
Jacobs, C., L. Huang, E. Bartowsky, S. Normark, and J.T. Park. (1994). Bacterial cell wall recycling provides cystolic muropeptides as effectors for β-lactamase induction. EMBO J. 13: 4684-4694. 7925310
Jansen, J., E.C. Friesema, M.H. Kester, C.E. Schwartz, and T.J. Visser. (2008). Genotype-phenotype relationship in patients with mutations in thyroid hormone transporter MCT8. Endocrinology 149(5): 2184-2190. 18187543
Jeanguenin, L., A. Lara-Núñez, D.A. Rodionov, A.L. Osterman, N.Y. Komarova, D. Rentsch, J.F. Gregory, 3rd, and A.D. Hanson. (2012). Comparative genomics and functional analysis of the NiaP family uncover nicotinate transporters from bacteria, plants, and mammals. Funct Integr Genomics 12: 25-34. 21953179
Jensen, L.T., M. Ajua-Alemanji, and V. Cizewski Culotta. (2003). The Saccharomyces cerevisiae high affinity phosphate transporter encoded by PHO84 also functions in manganese homeostasis. J. Biol. Chem. 278: 42036-42040. 12923174
Jia, W., N. Tovell, S. Clegg, M. Trimmer, and J. Cole. (2009). A single channel for nitrate uptake, nitrite export and nitrite uptake by Escherichia coli NarU and a role for NirC in nitrite export and uptake. Biochem. J. 417: 297-304. 18691156
Jiang, D., Y. Zhao, J. Fan, X. Liu, Y. Wu, W. Feng, and X.C. Zhang. (2014). Atomic resolution structure of the E. coli YajR transporter YAM domain. Biochem. Biophys. Res. Commun. 450: 929-935. 24952155
Jiang, D., Y. Zhao, X. Wang, J. Fan, J. Heng, X. Liu, W. Feng, X. Kang, B. Huang, J. Liu, and X.C. Zhang. (2013). Structure of the YajR transporter suggests a transport mechanism based on the conserved motif A. Proc. Natl. Acad. Sci. USA 110: 14664-14669. 23950222
Jin, J., A.A. Guffanti, C. Beck, and T.A. Krulwich. (2001). Twelve-transmembrane-segment (TMS) version (*TMS VII-VIII) of the 14-TMS Tel(L) antibiotic resistance protein retains monovalent cation transport modes but lacks tetracycline efflux capacity. J. Bacteriol. 183: 2667-2671. 11274128
Jin, J., A.A. Guffanti, D.H. Bechhofer, and T.A. Krulwich. (2002). Tet(L) and Tet(K) tetracycline-divalent metal/H+ antiporters: characterization of multiple catalytic modes and a mutagenesis approach to differences in their efflux substrate and coupling ion preferences. J. Bacteriol. 184: 4722-4732. 12169596
Johannes, J., D. Braun, A. Kinne, D. Rathmann, J. Köhrle, and U. Schweizer. (2016). Few amino acid exchanges expand the substrate spectrum of monocarboxylate transporter 10. Mol Endocrinol me20161037. [Epub: Ahead of Print] 27244477
Johannes, J., R. Jayarama-Naidu, F. Meyer, E. Katrin Wirth, U. Schweizer, L. Schomburg, J. Köhrle, and K. Renko. (2016). Silychristin, a flavonolignan derived from the milk thistle is a potent inhibitor of the thyroid hormone transporter MCT8. Endocrinology en20151933. [Epub: Ahead of Print] 26910310
Johansen, L.E., P. Nygaard, C. Lassen, Y. Agerso, and H.H. Saxild. (2003). Definition of a second Bacillus subtilis pur regulon comprising the pur and xpt-pbuX operons plus pbuG, nupG (yxjA), and pbuE (ydhL). J. Bacteriol. 185: 5200-5209. 12923093
Johansson, L. and G. Lidén. (2006). Transcriptome analysis of a shikimic acid producing strain of Escherichia coli W3110 grown under carbon- and phosphate-limited conditions. J Biotechnol 126: 528-545. 16828913
Johnston, M. (1999). Feasting, fasting and fermenting, glucose sensing in yeast and other cells. Trends Genet. 15: 29-33. 10087931
Jones, R.S. and M.E. Morris. (2016). Monocarboxylate Transporters: Therapeutic Targets and Prognostic Factors in Disease. Clin Pharmacol Ther 100: 454-463. 27351344
Joost, H.-G. and B. Thorens. (2001). The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members. Mol. Membr. Biol. 18: 247-256. 11780753
Juge, N., Y. Yoshida, S. Yatsushiro, H. Omote, and Y. Moriyama. (2006). Vesicular glutamate transporter contains two independent transport machineries. J. Biol. Chem. 281: 39499-39506. 17046815
Jutabha, P., Y. Kanai, M. Hosoyamada, A. Chairoungdua, D.K. Kim, Y. Iribe, E. Babu, J.Y. Kim, N. Anzai, V. Chatsudthipong, and H. Endou. (2003). Identification of a novel voltage-driven organic anion tansporter present at apical membrane of renal proximal tubule. J. Biol. Chem. 278: 27930-27938. 12740363
Jørgensen T.R., P.A. vanKuyk, B.R. Poulsen, G.J. Ruijter, J. Visser, J.J. Iversen. (2007). Glucose uptake and growth of glucose-limited chemostat cultures of Aspergillus niger and a disruptant lacking MstA, a high-affinity glucose transporter. Microbiology. 153: 1963-1973. 17526853
Kaback, H.R. (2015). A chemiosmotic mechanism of symport. Proc. Natl. Acad. Sci. USA 112: 1259-1264. 25568085
Kaback, H.R. and J. Wu. (1997). From membrane to molecule to the third amino acid from the left with a membrane transport protein. Quart. Rev. Biophys. 30: 333-364. 9634651
Kaler, G., D.M. Truong, A. Khandelwal, M. Nagle, S.A. Eraly, P.W. Swaan, and S.K. Nigam. (2007). Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. J. Biol. Chem. 282: 23841-23853. 17553798
Kanamori, A., J. Nakayama, M.N. Fukuda, W.B. Stallcup, K. Sasaki, M. Fukuda, and Y. Hirabayashi. (1997). Expression cloning and characterization of a cDNA encoding a novel membrane protein required for the formation of O-acetylated ganglioside: a putative acetyl-CoA transporter. Proc. Natl. Acad. Sci. USA 94: 2897-2902. 9096318
Kanamori, Y., A. Saito, Y. Hagiwara-Komoda, D. Tanaka, K. Mitsumasu, S. Kikuta, M. Watanabe, R. Cornette, T. Kikawada, and T. Okuda. (2010). The trehalose transporter 1 gene sequence is conserved in insects and encodes proteins with different kinetic properties involved in trehalose import into peripheral tissues. Insect Biochem Mol Biol 40: 30-37. 20035867
Karimian, M. and L.N. Ornston. (1981). Participation of the β-ketoadipate transport system in chemotaxis. J Gen Microbiol 124: 25-28. 7320700
Kasahara, T. and M. Kasahara. (2010). Identification of a key residue determining substrate affinity in the yeast glucose transporter Hxt7: a two-dimensional comprehensive study. J. Biol. Chem. 285: 26263-26268. 20525688
Kasahara, T., K. Shimogawara, and M. Kasahara. (2011). Crucial effects of amino acid side chain length in transmembrane segment 5 on substrate affinity in yeast glucose transporter Hxt7. Biochemistry 50: 8674-8681. 21892826
Kasho, V.N., I.N. Smirnova, and H.R. Kaback. (2006). Sequence alignment and homology threading reveals prokaryotic and eukaryotic proteins similar to lactose permease. J. Mol. Biol. 358: 1060-1070. 16574153
Kaur, J. and A.K. Bachhawat. (2007). Yct1p, a novel, high-affinity, cysteine-specific transporter from the yeast Saccharomyces cerevisiae. Genetics 176: 877-890. 17435223
Kawahara, A., T. Nishi, Y. Hisano, H. Fukui, A. Yamaguchi, and N. Mochizuki. (2009). The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors. Science 323: 524-527. 19074308
Kawano-Kawada M., Pongcharoen P., Kawahara R., Yasuda M., Yamasaki T., Akiyama K., Sekito T. and Kakinuma Y. (2016). Vba4p, a vacuolar membrane protein, is involved in the drug resistance and vacuolar morphology of Saccharomyces cerevisiae. Biosci Biotechnol Biochem. 80(2):279-87. 26325352
Kaya A., Karakaya HC., Fomenko DE., Gladyshev VN. and Koc A. (2009). Identification of a novel system for boron transport: Atr1 is a main boron exporter in yeast. Mol Cell Biol. 29(13):3665-74. 19414602
Kayingo, G., A. Martins, R. Andrie, L. Neves, C. Lucas, and B. Wong. (2009). A permease encoded by STL1 is required for active glycerol uptake by Candida albicans. Microbiology 155: 1547-1557. 19383674
Kazakov, T., A. Metlitskaya, and K. Severinov. (2007). Amino acid residues required for maturation, cell uptake, and processing of translation inhibitor microcin C. J. Bacteriol. 189: 2114-2118. 17158672
Keates, R.A., D.E. Culham, Y.I. Vernikovska, A.J. Zuiani, J.M. Boggs, and J.M. Wood. (2010). Transmembrane helix I and periplasmic loop 1 of Escherichia coli ProP are involved in osmosensing and osmoprotectant transport. Biochemistry 49: 8847-8856. 20828170
Keel, S.B., R.T. Doty, Z. Yang, J.G. Quigley, J. Chen, S. Knoblaugh, P.D. Kingsley, I. De Domenico, M.B. Vaughn, J. Kaplan, J. Palis, and J.L. Abkowitz (2008). A heme export protein is required for red blood cell differentiation and iron homeostasis. Science 319: 825-828. 18258918
Kekuda, R., P.D. Prasad, X. Wu, H. Wang, Y.-J. Fei, F.H. Leibach, and V. Ganapathy. (1998). Cloning and functional characterization of a potential-sensitive polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. J. Biol. Chem. 273: 15971-15979. 9632645
Kemp, B.J., D.L. Church, J. Hatzold, B. Conradt, and E.J. Lambie. (2009). Gem-1 encodes an SLC16 monocarboxylate transporter-related protein that functions in parallel to the gon-2 TRPM channel during gonad development in Caenorhabditis elegans. Genetics 181: 581-591. 19087963
Khalfaoui-Hassani, B., A.F. Verissimo, H.G. Koch, and F. Daldal. (2016). Uncovering the Transmembrane Metal Binding Site of the Novel Bacterial Major Facilitator Superfamily-Type Copper Importer CcoA. MBio 7:. 26787831
Khan, A.A. and J.G. Quigley. (2011). Control of intracellular heme levels: heme transporters and heme oxygenases. Biochim. Biophys. Acta. 1813: 668-682. 21238504
Khan, A.A., T. Hanada, M. Mohseni, J.J. Jeong, L. Zeng, M. Gaetani, D. Li, B.C. Reed, D.W. Speicher, and A.H. Chishti. (2008). Dematin and adducin provide a novel link between the spectrin cytoskeleton and human erythrocyte membrane by directly interacting with glucose transporter-1. J. Biol. Chem. 283: 14600-14609. 18347014
Khare, P., A. Mulakaluri, and S.M. Parsons. (2010). Search for the acetylcholine and vesamicol binding sites in vesicular acetylcholine transporter: the region around the lumenal end of the transport channel. J Neurochem 115: 984-993. 20831599
Kikawada, T., A. Saito, Y. Kanamori, Y. Nakahara, K. Iwata, D. Tanaka, M. Watanabe, and T. Okuda. (2007). Trehalose transporter 1, a facilitated and high-capacity trehalose transporter, allows exogenous trehalose uptake into cells. Proc. Natl. Acad. Sci. USA 104: 11585-11590. 17606922
Kim JY. and Kandror KV. (2012). The first luminal loop confers insulin responsiveness to glucose transporter 4. Mol Biol Cell. 23(5):910-7. 22262463
Kim M.G., F.A. Flomerfelt, K.N. Lee, C. Chen, R.H. Schwartz. (2000). A putative 12 transmembrane domain cotransporter expressed in thymic cortical epithelial cells. J. Immunol. 164:3185-3192. 10706709
Kim, O.B., H. Richter, T. Zaunmüller, S. Graf, and G. Unden. (2011). Role of secondary transporters and phosphotransferase systems in glucose transport by Oenococcus oeni. J. Bacteriol. 193: 6902-6911. 22020640
Kimura, Y., S. Ishida, H. Matoba, and N. Okahisa. (2004). A Myxococcus xanthus rppA-mmrA double mutant exhibits reduced uptake of amino acids and tolerance of some antimicrobials. FEMS Microbiol. Lett. 238: 145-150. 15336415
Kinne, A., G. Kleinau, C.S. Hoefig, A. Grüters, J. Köhrle, G. Krause, and U. Schweizer. (2010). Essential molecular determinants for thyroid hormone transport and first structural implications for monocarboxylate transporter 8. J. Biol. Chem. 285: 28054-28063. 20628049
Kinne, A., R. Schülein, and G. Krause. (2011). Primary and secondary thyroid hormone transporters. Thyroid Res 4Suppl1: S7. 21835054
Kitagawa, W., S. Takami, K. Miyauchi, E. Masai, Y. Kamagata, J.M. Tiedje, and M. Fukuda. (2002). Novel 2,4-dichlorophenoxyacetic acid degradation genes from oligotrophic Bradyrhizobium sp. strain HW13 isolated from a pristine environment. J. Bacteriol. 184: 509-518. 11751829
Klepek, Y.S., D. Geiger, R. Stadler, F. Klebl, L. Landouar-Arsivaud, R. Lemoine, R. Hedrich, and N. Sauer. (2005). Arabidopsis POLYOL TRANSPORTER5, a new member of the monosaccharide transporter-like superfamily, mediates H+-Symport of numerous substrates, including myo-inositol, glycerol, and ribose. Plant Cell 17: 204-218. 15598803
Koepsell, H. (1998). Organic cation transporters in intestine, kidney, liver, and brain. Annu. Rev. Physiol. 60: 243-266. 9558463
Koepsell, H. (2013). The SLC22 family with transporters of organic cations, anions and zwitterions. Mol Aspects Med 34: 413-435. 23506881
Koepsell, H., V. Gorboulev, and P. Arndt. (1999). Molecular pharmacology of organic cation transporters in kidney. J. Membr. Biol. 167: 103-117. 9916142
Kohyama, N., H. Shiokawa, M. Ohbayashi, Y. Kobayashi, and T. Yamamoto. (2013). Characterization of monocarboxylate transporter 6: expression in human intestine and transport of the antidiabetic drug nateglinide. Drug Metab Dispos 41: 1883-1887. 23935065
Koita, K. and C.V. Rao. (2012). Identification and analysis of the putative pentose sugar efflux transporters in Escherichia coli. PLoS One 7: e43700. 22952739
Kong, K.F., A. Aguila, L. Schneper, and K. Mathee. (2010). Pseudomonas aeruginosa β-lactamase induction requires two permeases, AmpG and AmpP. BMC Microbiol 10: 328. 21192796
Kramer, W., H.J. Burger, W.J. Arion, D. Corsiero, F. Girbig, C. Weyland, H. Hemmerle, S. Petry, P. Habermann, and A. Herling. (1999). Identification of protein components of the microsomal glucose 6-phosphate transporter by photoaffinity labelling. J. Biochem. 339: 629-638. 10215602
Krings, E., K. Krumbach, B. Bathe, R. Kelle, V.F. Wendisch, H. Sahm, and L. Eggeling. (2006). Characterization of myo-inositol utilization by Corynebacterium glutamicum: the stimulon, identification of transporters, and influence on L-lysine formation. J. Bacteriol. 188: 8054-8061. 16997948
Kroeger, J.K., K. Hassan, A. Vörös, R. Simm, M. Saidijam, K.E. Bettaney, A. Bechthold, I.T. Paulsen, P.J. Henderson, and A.B. Kolstø. (2015). Bacillus cereus efflux protein BC3310 - a multidrug transporter of the unknown major facilitator family, UMF-2. Front Microbiol 6: 1063. 26528249
Kröger, C., J. Stolz, and T.M. Fuchs. (2010). myo-Inositol transport by Salmonella enterica serovar Typhimurium. Microbiology 156: 128-138. 19833776
Kulakova, A.N., L.A. Kulakov, N.V. Akulenko, V.N. Ksenzenko, J.T. Hamilton, and J.P. Quinn. (2001). Structural and functional analysis of the phosphonoacetate hydrolase (phnA) gene region in Pseudomonas fluorescens 23F. J. Bacteriol. 183: 3268-3275. 11344133
Kusuhara, H., T. Sekine, N. Utsunomiya-Tate, M. Tsuda, R. Kojima, S.H. Cha, Y. Sugiyama, Y. Kanai, and H. Endou. (1999). Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J. Biol. Chem. 274: 13675-13680. 10224140
Langford, C.K., M.P. Kavanaugh, P.E. Stenberg, M.E. Drew, W. Zhang, and S.M. Landfear. (1995). Functional expression and subcellular localization of a high-Kmhexose transporter from Leishmania donovani. Biochemistry 34: 11814-11821. 7547915
Latunde-Dada, G.O., R.J. Simpson, and A.T. McKie. (2006). Recent advances in mammalian haem transport. Trends Biochem. Sci. 31: 182-188. 16487711
Laurent M., B. Aude and R. Cornelia. (2007). Ferripyochelin uptake genes are involved in pyochelin-mediated signaling in Pseudomonas aeruginosa. Microbiology 153: 1508-1518.
Law, C.J., P.C. Maloney, and D.N. Wang. (2008). Ins and outs of major facilitator superfamily antiporters. Annu. Rev. Microbiol. 62: 289-305. 18537473
Law, C.J., Q. Yang, C. Soudant, P.C. Maloney, and D.N. Wang. (2007). Kinetic evidence is consistent with the rocker-switch mechanism of membrane transport by GlpT. Biochemistry. 46: 12190-12197. 17915951
Lazard, M., S. Blanquet, P. Fisicaro, G. Labarraque, and P. Plateau. (2010). Uptake of selenite by Saccharomyces cerevisiae involves the high and low affinity orthophosphate transporters. J. Biol. Chem. 285: 32029-32037. 20688911
Leach, L.H. and T.A. Lewis. (2006). Identification and characterization of Pseudomonas membrane transporters necessary for utilization of the siderophore pyridine-2,6-bis(thiocarboxylic acid) (PDTC). Microbiology 152: 3157-3166. 17005994
Leandro, M.J., H. Sychrová, C. Prista, and M.C. Loureiro-Dias. (2011). The osmotolerant fructophilic yeast Zygosaccharomyces rouxii employs two plasma-membrane fructose uptake systems belonging to a new family of yeast sugar transporters. Microbiology 157: 601-608. 21051487
Leandro, M.J., I. Spencer-Martins, and P. Gonçalves. (2008). The expression in Saccharomyces cerevisiae of a glucose/xylose symporter from Candida intermedia is affected by the presence of a glucose/xylose facilitator. Microbiology 154: 1646-1655. 18524919
Leandro, M.J., P. Gonçalves, and I. Spencer-Martins. (2006). Two glucose/xylose transporter genes from the yeast Candida intermedia: first molecular characterization of a yeast xylose-H+ symporter. Biochem. J. 395: 543-549. 16402921
Lee, E.-H., C. Rouquette-Loughlin, J.P. Folster, and W.M. Shafer. (2003). FarR regulates the farAB-encoded efflux pump of Neisseria gonorrhoeae via an MtrR regulatory mechanism. J. Bacteriol. 185: 7145-7152. 14645274
Lee, E.H., S.A. Hill, R. Napier, and W.M. Shafer. (2006). Integration Host Factor is required for FarR repression of the farAB-encoded efflux pump of Neisseria gonorrhoeae. Mol Microbiol. 60: 1381-1400. 16796676
Lee, L.F., Y.J. Chen, R. Kirby, C. Chen, and C.W. Chen. (2007). A multidrug efflux system is involved in colony growth in Streptomyces lividans. Microbiology. 153: 924-934. 17379703
Lei, M., Q. Cheng, Y. Zhao, T. Liu, X. Wang, Y. Deng, J. Yang, and Z. Zhang. (2012). [Expression and Its Clinical Significance of SLC22A18 in Non-small Cell Lung Cancer]. Zhongguo Fei Ai Za Zhi 15: 17-20. 22237119
Lelandais-Brière, C., M. Jovanovic, G.A. Torres, Y. Perrin, R. Lemoine, F. Corre-Menguy, and C. Hartmann. (2007). Disruption of AtOCT1, an organic cation transporter gene, affects root development and carnitine-related responses in Arabidopsis. Plant J. 51: 154-164. 17521409
Lemieux, M.J. (2007). Eukaryotic major facilitator superfamily transporter modeling based on the prokaryotic GlpT crystal structure. Mol. Membr. Biol. 24: 333-341. 17710637
Lemieux, M.J., Y. Huang, and d.a.N. Wang. (2005). Crystal structure and mechanism of GlpT, the glycerol-3-phosphate transporter from E. coli. J Electron Microsc (Tokyo) 54Suppl1: i43-46. 16157640
Lesuisse, E., M. Simon-Casteras, and P. Labbe. (1998). Siderophore-mediated iron uptake in Saccharomyces cerevisiae: the SIT1 gene encodes a ferrioxamine B permease that belongs to the major facilitator superfamily. Microbiology 144: 3455-3462. 9884238
Lewinson O., J. Adler, N. Sigal, E. Bibi. (2006). Promiscuity in multidrug recognition and transport: the bacterial MFS Mdr transporters. Mol. Microbiol. 61: 277-284. 16856936
Lewinson, O., and E. Bibi. (2001). Evidence for simultaneous binding of dissimilar substrates by the Escherichia coli multidrug transporter MdfA. Biochem. 40: 12612-12618. 11601985
Lewis, J.A., A.R. Horswill, B.E. Schwem, and J.C. Escalante-Semerena. (2004). The tricarballylate utilization (tcuRABC) genes of Salmonella enterica serovar Typhimurium LT2. J. Bacteriol. 186: 1629-1637. 14996793
Leyn, S.A., F. Gao, C. Yang, and D.A. Rodionov. (2012). N-acetylgalactosamine utilization pathway and regulon in proteobacteria: genomic reconstruction and experimental characterization in Shewanella. J. Biol. Chem. 287: 28047-28056. 22711537
Li H., Fan R., Li L., Wei B., Li G., Gu L., Wang X. and Zhang X. (2014). Identification and characterization of a novel copper transporter gene family TaCT1 in common wheat. Plant Cell Environ. 37(7):1561-73. 24372025
Li, X., H. Yang, D. Zhang, X. Li, H. Yu, and Z. Shen. (2015). Overexpression of specific proton motive force-dependent transporters facilitate the export of surfactin in Bacillus subtilis. J Ind Microbiol Biotechnol 42: 93-103. 25366377
Li, X.Z., L. Zhang, and H. Nikaido. (2004). Efflux pump-mediated intrinsic drug resistance in Mycobacterium smegmatis. Antimicrob. Agents Chemother. 48: 2415-2423. 15215089
Lin, Y., M. Bogdanov, S. Tong, Z. Guan, and L. Zheng. (2016). Substrate Selectivity of Lysophospholipid Transporter LplT Involved in Membrane Phospholipid Remodeling in Escherichia coli. J. Biol. Chem. 291: 2136-2149. 26613781
Lindquist, S., K. Weston-Hafer, H. Schmidt, C. Pul, G. Korfmann, J. Erickson, C. Sanders, H.H. Martin, and S. Normark. (1993). AmpG, a single transducer in chromosomal β-lactamase induction. Mol. Microbiol. 9: 703-715. 8231804
Liu, H., Y. Wang, C. Wu, S. Schwarz, Z. Shen, B. Jeon, S. Ding, Q. Zhang, and J. Shen. (2012). A novel phenicol exporter gene, fexB, found in enterococci of animal origin. J Antimicrob Chemother 67: 322-325. 22096043
Liu, J., W.K. Versaw, N. Pumplin, S.K. Gomez, L.A. Blaylock, and M.J. Harrison. (2008). Closely related members of the Medicago truncatula PHT1 phosphate transporter gene family encode phosphate transporters with distinct biochemical activities. J. Biol. Chem. 283: 24673-24681. 18596039
Liu, J.Y., P.F. Miller, J. Willard, and E.R. Olson. (1999). Functional and biochemical characterization of Escherichia coli sugar efflux transporters. J. Biol. Chem. 274: 22977-22984. 10438463
Liu, J.Y., P.F. Miller, M. Gosink, and E.R. Olson. (1999). The identification of a new family of sugar efflux pumps in Escherichia coli. Mol. Microbiol. 31: 1845-1851. 10209755
Liu, K.-H. and Y.-F. Tsay. (2003). Switching between the two action modes of the dual-affinity nitrate transporter CHL1 by phosphorylation. EMBO J. 22: 1005-1013. 12606566
Liu, M., J. Liu, and W.M. Wang. (2012). Isolation and functional analysis of Thmfs1, the first major facilitator superfamily transporter from the biocontrol fungus Trichoderma harzianum. Biotechnol Lett 34: 1857-1862. 22661043
Liu, Y., D. Peter, A. Roghani, S. Schuldiner, G.G. Prive, D. Eisenberg, N. Brecha, and R.H. Edwards. (1992). A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter. Cell 70: 539-551. 1505023
Liu, Y., F. Liu, K. Iqbal, I. Grundke-Iqbal, and C.X. Gong. (2008). Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease. FEBS Lett. 582: 359-364. 18174027
Liu, Z., E. Boles, and B.P. Rosen. (2004). Arsenic trioxide uptake by hexose permeases in Saccharomyces cerevisiae. J. Biol. Chem. 279: 17312-17318. 14966117
Locher, K.P., R.B. Bass, and D.C. Rees. (2003). Breaching the barrier. Science 301: 603-604. 12893929
Lodder-Gadaczek, J., V. Gieselmann, and M. Eckhardt. (2013). Vesicular uptake of N-acetylaspartylglutamate is catalysed by sialin (SLC17A5). Biochem. J. 454: 31-38. 23889254
Lofthouse EM., Brooks S., Cleal JK., Hanson MA., Poore KR., O'Kelly IM. and Lewis RM. (2015). Glutamate cycling may drive organic anion transport on the basal membrane of human placental syncytiotrophoblast. J Physiol. 593(20):4549-59. 26277985
Lorca, G.L., R.D. Barabote, V. Zlotopolski, C. Tran, B. Winnen, R.N. Hvorup, A.J. Stonestrom, E. Nguyen, L.W. Huang, D.S. Kim, and M.H. Saier, Jr. (2007). Transport capabilities of eleven gram-positive bacteria: comparative genomic analyses. Biochim. Biophys. Acta. 1768: 1342-1366. 17490609
Ma, Y., J. Patel, and R.J. Parry. (2000). A novel valanimycin-resistance determinant (vlmF) from Streptomyces viridifaciens MG456-hF10. Microbiology 146(Pt2): 345-352. 10708373
MacMillan, S.V., D.A. Alexander, D.E. Culham, H.J. Kunte, E.V. Marshall, D. Rochon, and J.M. Wood. (1999). The ion coupling and organic substrate specificities of osmoregulatory transporter ProP in Escherichia coli. Biochim. Biophys. Acta 1420: 30-44. 10446288
Madej, M.G., S.N. Soro, and H.R. Kaback. (2012). Apo-intermediate in the transport cycle of lactose permease (LacY). Proc. Natl. Acad. Sci. USA 109: E2970-2978. 23012238
Magalhães, F., V. Vidgren, L. Ruohonen, and B. Gibson. (2016). Maltose and maltotriose utilisation by group I strains of the hybrid lager yeast Saccharomyces pastorianus. FEMS Yeast Res 16:. 27364826
Mallonee, D.H. and P.B. Hylemon. (1996). Sequencing and expression of a gene encoding a bile acid transporter from Eubacterium sp. strain VPI 12708. J. Bacteriol. 178: 7053-7058. 8955384
Mandal A., Kumar A., Singh A., Lynn AM., Kapoor K. and Prasad R. (2012). A key structural domain of the Candida albicans Mdr1 protein. Biochem J. 445(3):313-22. 22587419
Manel, N., F.J. Kim, S. Kinet, N. Taylor, M. Sitbon, and J.-L. Battini. (2003). The ubiquitous glucose transporter GLUT-1 is a receptor for HTLV. Cell 115: 449-459. 14622599
Manolescu, A., A.M. Salas-Burgos, J. Fischbarg, and C.I. Cheeseman. (2005). Identification of a hydrophobic residue as a key determinant of fructose transport by the facilitative hexose transporter SLC2A7 (GLUT7). J. Biol. Chem. 280: 42978-42983. 16186102
Mansfield, T.A., N.P. Schultes, and G.S. Mourad. (2009). AtAzg1 and AtAzg2 comprise a novel family of purine transporters in Arabidopsis. FEBS Lett. 583: 481-486. 19121308
Mardones, L., V. Ormazabal, X. Romo, C. Jaña, P. Binder, E. Peña, M. Vergara, and F.A. Zúñiga. (2011). The glucose transporter-2 (GLUT2) is a low affinity dehydroascorbic acid transporter. Biochem. Biophys. Res. Commun. 410: 7-12. 21621509
Marger, M.D. and M.H. Saier, Jr. (1993). A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport. Trends Biochem. Sci. 18: 13-20. 8438231
Mariotta L., Ramadan T., Singer D., Guetg A., Herzog B., Stoeger C., Palacin M., Lahoutte T., Camargo SM. and Verrey F. (2012). T-type amino acid transporter TAT1 (Slc16a10) is essential for extracellular aromatic amino acid homeostasis control. J Physiol. 590(Pt 24):6413-24. 23045339
Martín-Venegas, R., M.J. Rodríguez-Lagunas, P.A. Geraert, and R. Ferrer. (2007). Monocarboxylate transporter 1 mediates DL-2-Hydroxy-(4-methylthio)butanoic acid transport across the apical membrane of Caco-2 cell monolayers. J. Nutr. 137: 49-54. 17182800
Martin, V.J.J. and W.W. Mohn. (2000). Genetic investigation of the catabolic pathway for degradation of abietane diterpenoids by Pseudomonas abietaniphila BKME-9. J. Bacteriol. 182: 3784-3793. 10850995
Martinez-Garriga, B., T. Vinuesa, J. Hernandez-Borrell, and M. Viñas. (2007). The contribution of efflux pumps to quinolone resistance in Streptococcus pneumoniae clinical isolates. Int. J. Med. Microbiol. 297: 187-195. 17350332
Martinez-Jéhanne, V., L. du Merle, C. Bernier-Fébreau, C. Usein, A. Gassama-Sow, A.A. Wane, M. Gouali, M. Damian, A. Aïdara-Kane, Y. Germani, A. Fontanet, B. Coddeville, Y. Guérardel, and C. Le Bouguénec. (2009). Role of deoxyribose catabolism in colonization of the murine intestine by pathogenic Escherichia coli strains. Infect. Immun. 77: 1442-1450. 19168744
Martinussen, J., C. Sørensen, C.B. Jendresen, and M. Kilstrup. (2010). Two nucleoside transporters in Lactococcus lactis with different substrate specificities. Microbiology 156: 3148-3157. 20595258
Maruyama, S.Y., M. Ito, Y. Ikami, Y. Okitsu, C. Ito, K. Toshimori, W. Fujii, and K. Yogo. (2016). A critical role of solute carrier 22a14 in sperm motility and male fertility in mice. Sci Rep 6: 36468. 27811987
Masureel M., Martens C., Stein RA., Mishra S., Ruysschaert JM., Mchaourab HS. and Govaerts C. (2014). Protonation drives the conformational switch in the multidrug transporter LmrP. Nat Chem Biol. 10(2):149-55. 24316739
Matherly LH., Wilson MR. and Hou Z. (2014). The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer. Drug Metab Dispos. 42(4):632-49. 24396145
Mathews EA., Mullen GP., Hodgkin J., Duerr JS. and Rand JB. (2012). Genetic interactions between UNC-17/VAChT and a novel transmembrane protein in Caenorhabditis elegans. Genetics. 192(4):1315-25. 23051648
Maulén, N.P., E.A. Henríquez, S. Kempe, J.G. Cárcamo, A. Schmid-Kotsas, M. Bachem, A. Grünert, M.E. Bustamante, F. Nualart, and J.C. Vera. (2003). Up-regulation and polarized expression of the sodium-ascorbic acid transporter SVCT1 in post-confluent differentiated CaCo-2 cells. J. Biol. Chem. 278: 9035-9041. 12381735
McGee, S.L. and M. Hargreaves. (2006). Exercise and skeletal muscle glucose transporter 4 expression: molecular mechanisms. Clin Exp Pharmacol Physiol 33: 395-399. 16620308
Michel, L., A. Bachelard, and C. Reimmann. (2007). Ferripyochelin uptake genes are involved in pyochelin-mediated signalling in Pseudomonas aeruginosa. Microbiology 153: 1508-1518. 17464065
Miethke, M., S. Schmidt, and M.A. Marahiel. (2008). The major facilitator superfamily-type transporter YmfE and the multidrug-efflux activator Mta mediate bacillibactin secretion in Bacillus subtilis. J. Bacteriol. 190: 5143-5152. 18502870
Miller, A.J., X. Fan, M. Orsel, S.J. Smith, and D.M. Wells. (2007). Nitrate transport and signalling. J Exp Bot 58: 2297-306. 17519352
Miura, D., N. Anzai, P. Jutabha, S. Chanluang, X. He, T. Fukutomi, and H. Endou. (2011). Human urate transporter 1 (hURAT1) mediates the transport of orotate. J. Physiol. Sci 61: 253-257. 21350910
Montel-Hagen, A., S. Kinet, N. Manel, C. Mongellaz, R. Prohaska, J.L. Battini, J. Delaunay, M. Sitbon, and N. Taylor. (2008). Erythrocyte Glut1 triggers dehydroascorbic acid uptake in mammals unable to synthesize vitamin C. Cell 132: 1039-1048. 18358815
Moore, R.E., Y. Kim, and C.C. Philpott. (2003). The mechanism of ferrichrome transport through Arn1p and its metabolism in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 100: 5664-5669. 12721368
Moraes, T.F. and R.A. Reithmeier. (2012). Membrane transport metabolons. Biochim. Biophys. Acta. 1818: 2687-2706. 22705263
Moraleda-Muñoz, A., J. Pérez, A.L. Extremera, and J. Muñoz-Dorado. (2010). Differential regulation of six heavy metal efflux systems in the response of Myxococcus xanthus to copper. Appl. Environ. Microbiol. 76: 6069-6076. 20562277
Morin, P., C. Sagné, and B. Gasnier. (2004). Functional characterization of wild-type and mutant human sialin. EMBO. J. 23: 4560-4570. 15510212
Morishita, M. and J. Engebrecht. (2008). Sorting signals within the Saccharomyces cerevisiae sporulation-specific dityrosine transporter, Dtr1p, C terminus promote Golgi-to-prospore membrane transport. Eukaryot. Cell. 7: 1674-1684. 18676951
Moschen I., Broer A., Galic S., Lang F. and Broer S. (2012). Significance of short chain fatty acid transport by members of the monocarboxylate transporter family (MCT). Neurochem Res. 37(11):2562-8. 22878645
Mueckler, M. and C. Makepeace. (2009). Model of the exofacial substrate-binding site and helical folding of the human Glut1 glucose transporter based on scanning mutagenesis. Biochemistry 48: 5934-5942. 19449892
Murphy, P.J., S.P. Trenz, W. Grzemski, F.J. De Bruijn, and J. Schell. (1993). The Rhizobium meliloti rhizopine mos locus is a mosaic structure facilitating its symbiotic regulation. J. Bacteriol. 175: 5193-5204. 8349559
Naftalin, R.J. (2008). Osmotic water transport with glucose in GLUT2 and SGLT. Biophys. J. 94: 3912-3923. 18234816
Nagakubo, S., K. Nishino, T. Hirata, and A. Yamaguchi. (2002). The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC. J. Bacteriol. 184: 4161-4167. 12107133
Nair, A.V., H. Singh, S. Raturi, A. Neuberger, Z. Tong, N. Ding, K. Agboh, and H.W. van Veen. (2016). Relocation of active site carboxylates in major facilitator superfamily multidrug transporter LmrP reveals plasticity in proton interactions. Sci Rep 6: 38052. 27917857
Nakano, Y., K. Fujitani, J. Kurihara, J. Ragan, K. Usui-Aoki, L. Shimoda, T. Lukacsovich, K. Suzuki, M. Sezaki, Y. Sano, R. Ueda, W. Awano, M. Kaneda, M. Umeda, and D. Yamamoto. (2001). Mutations in the novel membrane protein spinster interfere with programmed cell death and cause neural degeneration in Drosophila melanogaster. Mol. Cell. Biol. 21: 3775-3788. 11340170
Nakata, T., T. Matsui, K. Kobayashi, Y. Kobayashi, and N. Anzai. (2013). Organic cation transporter 2 (SLC22A2), a low-affinity and high-capacity choline transporter, is preferentially enriched on synaptic vesicles in cholinergic neurons. Neuroscience 252: 212-221. 23958595
Nancolas, B., R.B. Sessions, and A.P. Halestrap. (2015). Identification of key binding site residues of MCT1 for AR-C155858 reveals the molecular basis of its isoform selectivity. Biochem. J. 466: 177-188. 25437897
Naseer, N., J.A. Shapiro, and M. Chander. (2014). RNA-Seq analysis reveals a six-gene SoxR regulon in Streptomyces coelicolor. PLoS One 9: e106181. 25162599
Naula, C.M., F.M. Logan, P.E. Wong, M.P. Barrett, and R.J. Burchmore. (2010). A glucose transporter can mediate ribose uptake: definition of residues that confer substrate specificity in a sugar transporter. J. Biol. Chem. 285: 29721-29728. 20601430
Nele Bourgeois, M.A., S.L. Van Herck, P. Vancamp, J. Delbaere, C. Zevenbergen, S. Kersseboom, V.M. Darras, and T.J. Visser. (2016). CHARACTERIZATION OF CHICKEN THYROID HORMONE TRANSPORTERS. Endocrinology en20152025. [Epub: Ahead of Print] 27070099
Nemoz, G., J. Robert-Baudouy, and F. Stoeber. (1976). Physiological and genetic regulation of the aldohexuronate transport system in Escherichia coli. J. Bacteriol. 127: 706-718. 783117
Nesper, J., A. Brosig, P. Ringler, G.J. Patel, S.A. Müller, J.H. Kleinschmidt, W. Boos, K. Diederichs, and W. Welte. (2008). Omp85(Tt) from Thermus thermophilus HB27: an ancestral type of the Omp85 protein family. J. Bacteriol. 190: 4568-4575. 18456816
Ng, T.S., S.Y. Chew, P. Rangasamy, M.N. Mohd Desa, D. Sandai, P.P. Chong, and L.T. Than. (2015). SNF3 as High Affinity Glucose Sensor and Its Function in Supporting the Viability of Candida glabrata under Glucose-Limited Environment. Front Microbiol 6: 1334. 26648919
Nichols, N.N. and C.S. Harwood. (1997). PcaK, a high-affinity permease for the aromatic compounds 4-hydroxybenzoate and protocatechuate from Pseudomonas putida. J. Bacteriol. 179: 5056-5061. 9260946
Nijnik, A., S. Clare, C. Hale, J. Chen, C. Raisen, L. Mottram, M. Lucas, J. Estabel, E. Ryder, H. Adissu, , N.C. Adams, R. Ramirez-Solis, J.K. White, K.P. Steel, G. Dougan, and R.E. Hancock. (2012). The role of sphingosine-1-phosphate transporter Spns2 in immune system function. J Immunol 189: 102-111. 22664872
Nishino, K. and A. Yamaguchi. (2001). Analysis of a complete library of putative drug transporter genes in Escherichia coli. J. Bacteriol. 183: 5803-5812. 11566977
Niu, C., G.A. Payne, and C.P. Woloshuk. (2016). Involvement of FST1 from Fusarium verticillioides in virulence and transport of inositol. Mol Plant Pathol. [Epub: Ahead of Print] 27195938
Nobre, A., C. Lucas, and C. Leão. (1999). Transport and utilization of hexoses and pentoses in the halotolerant yeast Debaryomyces hansenii. Appl. Environ. Microbiol. 65: 3594-3598. 10427054
Nomura N., Verdon G., Kang HJ., Shimamura T., Nomura Y., Sonoda Y., Hussien SA., Qureshi AA., Coincon M., Sato Y., Abe H., Nakada-Nakura Y., Hino T., Arakawa T., Kusano-Arai O., Iwanari H., Murata T., Kobayashi T., Hamakubo T., Kasahara M., Iwata S. and Drew D. (2015). Structure and mechanism of the mammalian fructose transporter GLUT5. Nature. 526(7573):397-401. 26416735
Norholm, M.H., H.H. Nour-Eldin, P. Brodersen, J. Mundy, and B.A. Halkier. (2006). Expression of the Arabidopsis high-affinity hexose transporter STP13 correlates with programmed cell death. FEBS Lett. 17: 2381-2387. 16616142
Nygaard, P. and H.H. Saxild. (2005). The purine efflux pump PbuE in Bacillus subtilis modulates expression of the PurR and G-box (XptR) regulons by adjusting the purine base pool size. J. Bacteriol. 187: 791-794. 15629952
Nørholm, M.H. and G. Dandanell. (2001). Specificity and topology of the Escherichia coli xanthosine permease, a representative of the NHS subfamily of the major facilitator superfamily. J. Bacteriol. 183: 4900-4904. 11466294
Oku, Y., K. Kurokawa, N. Ichihashi, and K. Sekimizu. (2004). Characterization of the Staphylococcus aureus mprF gene, involved in lysinylation of phosphatidylglycerol. Microbiology 150: 45-51. 14702396
Omote, H., T. Miyaji, N. Juge, and Y. Moriyama. (2011). Vesicular neurotransmitter transporter: bioenergetics and regulation of glutamate transport. Biochemistry 50: 5558-5565. 21612282
Ostash, I., B. Ostash, A. Luzhetskyy, A. Bechthold, S. Walker, and V. Fedorenko. (2008). Coordination of export and glycosylation of landomycins in Streptomyces cyanogenus S136. FEMS Microbiol. Lett. 285: 195-202. 18537830
Ovens, M.J., C. Manoharan, M.C. Wilson, C.M. Murray, and A.P. Halestrap. (2010). The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein. Biochem. J. 431: 217-225. 20695846
Ozcan, S. and M. Johnston. (1999). Function and regulation of yeast hexose transporters. Microbiol. Mol. Biol. Rev. 63: 554-569. 10477308
Périchon, B., P. Bogaerts, T. Lambert, L. Frangeul, P. Courvalin, and M. Galimand. (2008). Sequence of conjugative plasmid pIP1206 mediating resistance to aminoglycosides by 16S rRNA methylation and to hydrophilic fluoroquinolones by efflux. Antimicrob. Agents Chemother. 52: 2581-2592. 18458128
Périchon, B., P. Courvalin, and M. Galimand. (2007). Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. Antimicrob. Agents Chemother. 51: 2464-2469. 17470656
Pamp, S.J., M. Gjermansen, H.K. Johansen, and T. Tolker-Nielsen. (2008). Tolerance to the antimicrobial peptide colistin in Pseudomonas aeruginosa biofilms is linked to metabolically active cells, and depends on the pmr and mexAB-oprM genes. Mol. Microbiol. 68: 223-240. 18312276
Pan PY., Marrs J. and Ryan TA. (2015). Vesicular glutamate transporter 1 orchestrates recruitment of other synaptic vesicle cargo proteins during synaptic vesicle recycling. J Biol Chem. 290(37):22593-601. 26224632
Pan, C.J., S.Y. Chen, H.S. Jun, S.R. Lin, B.C. Mansfield, and J.Y. Chou. (2011). SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters. PLoS One 6: e23157. 21949678
Pao, S.S., I.T. Paulsen, and M.H. Saier, Jr. (1998). The major facilitator superfamily. Microbiol. Mol. Biol. Rev. 62: 1-32. 9529885
Parche, S., M. Beleut, E. Rezzonico, D. Jacobs, F. Arigoni, F. Titgemeyer, and I. Jankovic. (2006). Lactose-over-glucose preference in Bifidobacterium longum NCC2705: glcP, encoding a glucose transporter, is subject to lactose repression. J. Bacteriol. 188: 1260-1265. 16452407
Park, J.T., D. Raychaudhuri, H. Li, S. Normark, and D. Mengin-Lecreulx. (1998). MppA, a periplasmic binding protein essential for import of the bacterial cell wall peptide L-alanyl-γ-D-glutamyl-meso-diaminopimelate. J. Bacteriol. 180: 1215-1223. 9495761
Pascual, J.M., D. Wang, R. Yang, L. Shi, H. Yang, and D.C. De Vivo. (2008). Structural Signatures and Membrane Helix 4 in GLUT1: INFERENCES FROM HUMAN BLOOD-BRAIN GLUCOSE TRANSPORT MUTANTS. J. Biol. Chem. 283: 16732-16742. 18387950
Patching, S.G., G. Psakis, S.A. Baldwin, J. Baldwin, P.J. Henderson, and D.A. Middleton. (2008). Relative substrate affinities of wild-type and mutant forms of the Escherichia coli sugar transporter GalP determined by solid-state NMR. Mol. Membr. Biol. 25: 474-484. 18798051
Patching, S.G., S.A. Baldwin, A.D. Baldwin, J.D. Young, M.P. Gallagher, P.J. Henderson, and R.B. Herbert. (2005). The nucleoside transport proteins, NupC and NupG, from Escherichia coli: specific structural motifs necessary for the binding of ligands. Org Biomol Chem 3: 462-470. 15678184
Patrick PS., Lyons SK., Rodrigues TB. and Brindle KM. (2014). Oatp1 enhances bioluminescence by acting as a plasma membrane transporter for D-luciferin. Mol Imaging Biol. 16(5):626-34. 24798747
Paul, S., K.O. Alegre, S.R. Holdsworth, M. Rice, J.A. Brown, P. McVeigh, S.M. Kelly, and C.J. Law. (2014). A single-component multidrug transporter of the major facilitator superfamily is part of a network that protects Escherichia coli from bile salt stress. Mol. Microbiol. 92: 872-884. 24684269
Paulsen, I.T., M.H. Brown, and R.A. Skurray. (1996). Proton-dependent multidrug efflux systems. Microbiol. Rev. 60: 575-608. 8987357
Paulsen, I.T., S. Chauvaux, P. Choi, and M.H. Saier, Jr. (1998). Characterization of glucose-specific catabolite repression-resistant mutants of Bacillus subtilis: identification of a novel hexose:H+ symporter. J. Bacteriol. 180: 498-504. 9457850
Pavón, L.R., F. Lundh, B. Lundin, A. Mishra, B.L. Persson, and C. Spetea. (2008). Arabidopsis ANTR1 is a thylakoid Na+-dependent phosphate transporter: functional characterization in Escherichia coli. J. Biol. Chem. 283: 13520-13527. 18353780
Pedersen, B.P., H. Kumar, A.B. Waight, A.J. Risenmay, Z. Roe-Zurz, B.H. Chau, A. Schlessinger, M. Bonomi, W. Harries, A. Sali, A.K. Johri, and R.M. Stroud. (2013). Crystal structure of a eukaryotic phosphate transporter. Nature 496: 533-536. 23542591
Peekhaus, N. and T. Conway. (1998). What’s for dinner?: Entner-Doudoroff metabolism in Escherichia coli. J. Bacteriol 180: 3495-3502. 9657988
Pelis, R.M., X. Zhang, Y. Dangprapai, and S.H. Wright. (2006). Cysteine accessibility in the hydrophilic cleft of human organic cation transporter 2. J. Biol. Chem. 281: 35272-35280. 16990275
Pellizzaro A., Clochard T., Planchet E., Limami AM. and Morere-Le Paven MC. (2015). Identification and molecular characterization of Medicago truncatula NRT2 and NAR2 families. Physiol Plant. 154(2):256-69. 25430977
Pendse, P.Y., B.R. Brooks, and J.B. Klauda. (2010). Probing the periplasmic-open state of lactose permease in response to sugar binding and proton translocation. J. Mol. Biol. 404: 506-521. 20875429
Peng, Y., S. Kumar, R.L. Hernandez, S.E. Jones, K.M. Cadle, K.P. Smith, and M.F. Varela. (2009). Evidence for the transport of maltose by the sucrose permease, CscB, of Escherichia coli. J. Membr. Biol. 228: 79-88. 19294451
Pereira, C.A. and A.M. Silber. (2012). On the evolution of hexose transporters in kinetoplastid potozoans. PLoS One 7: e36303. 22567148
Perland, E., S.V. Hellsten, E. Lekholm, M.M. Eriksson, V. Arapi, and R. Fredriksson. (2016). The Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake. J Mol Neurosci. [Epub: Ahead of Print] 27981419
Perry, J.L., N. Dembla-Rajpal, L.A. Hall, and J.B. Pritchard. (2006). A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport. J. Biol. Chem. 281: 38071-38079. 17038320
Persson, B.L., A. Berhe, U. Fristedt, P. Martinez, J. Pattison, J. Petersson, and R. Weinander. (1998). Phosphate permeases of Saccharomyces cerevisiae. Biochim. Biophys. Acta 1365: 23-30. 9693717
Persson, B.L., J. Petersson, U. Fristedt, R. Weinander, A. Berhe, and J. Pattison. (1999). Phosphate permeases of Saccharomyces cerevisiae: structure, function and regulation. Biochim. Biophys. Acta 1422: 255-272. 10548719
Philip, M., S.A. Funkhouser, E.Y. Chiu, S.R. Phelps, J.J. Delrow, J. Cox, P.J. Fink, and J.L. Abkowitz. (2015). Heme Exporter FLVCR Is Required for T Cell Development and Peripheral Survival. J Immunol 194: 1677-1685. 25582857
Pietrancosta, N., C. Anne, H. Prescher, R. Ruivo, C. Sagné, C. Debacker, H.O. Bertrand, R. Brossmer, F. Acher, and B. Gasnier. (2012). Successful prediction of substrate-binding pocket in SLC17 transporter sialin. J. Biol. Chem. 287: 11489-11497. 22334707
Pimentel-Schmitt, E.F., K. Jahreis, M.P. Eddy, J. Amon, A. Burkovski, and F. Titgemeyer. (2009). Identification of a glucose permease from Mycobacterium smegmatis mc2 155. J. Mol. Microbiol. Biotechnol. 16: 169-175. 18311074
Pina, C., P. Goncalves, C. Prista, and M.C. Loureiro-Dias. (2004). Ffz1, a new transporter specific for fructose from Zygosaccharomyces bailii. Microbiology 150: 2429-2433. 15256584
Plourde-Owobi, L., S. Durner, J.L. Parrou, R. Wieczorke, G. Goma, and J. François. (1999). AGT1, encoding an α-glucoside transporter involved in uptake and intracellular accumulation of trehalose in Saccharomyces cerevisiae. J. Bacteriol. 181: 3830-3832. 10368160
Pochini, L., M. Scalise, M. Galluccio, and C. Indiveri. (2013). OCTN cation transporters in health and disease: role as drug targets and assay development. J Biomol Screen 18: 851-867. 23771822
Pochini, L., M. Scalise, S. Di Silvestre, S. Belviso, A. Pandolfi, A. Arduini, M. Bonomini, and C. Indiveri. (2015). Acetylcholine and acetylcarnitine transport in peritoneum: role of the SLC22A4 (OCTN1) transporter. Biochim. Biophys. Acta. [Epub: Ahead of Print] 26724204
Prestin, K., S. Wolf, R. Feldtmann, J. Hussner, I. Geissler, C. Rimmbach, H.K. Kroemer, U. Zimmermann, and H.E. Meyer zu Schwabedissen. (2014). Transcriptional regulation of urate transportosome member SLC2A9 by nuclear receptor HNF4α. Am. J. Physiol. Renal Physiol 307: F1041-1051. 25209865
Price, D.R., H.S. Wilkinson, and J.A. Gatehouse. (2007). Functional expression and characterisation of a gut facilitative glucose transporter, NlHT1, from the phloem-feeding insect Nilaparvata lugens (rice brown planthopper). Insect Biochem Mol Biol 37: 1138-1148. 17916500
Psakis, G., M. Saidijam, K. Shibayama, J. Polaczek, K.E. Bettaney, J.M. Baldwin, S.A. Baldwin, R. Hope, L.O. Essen, R.C. Essenberg, and P.J. Henderson. (2009). The sodium-dependent D-glucose transport protein of Helicobacter pylori. Mol. Microbiol. 71: 391-403. 19161491
Qin, L., X. Liu, Q. Sun, Z. Fan, D. Xia, G. Ding, H.L. Ong, D. Adams, W.A. Gahl, C. Zheng, S. Qi, L. Jin, C. Zhang, L. Gu, J. He, D. Deng, I.S. Ambudkar, and S. Wang. (2012). Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane. Proc. Natl. Acad. Sci. USA 109: 13434-13439. 22778404
Qiu, A., M. Jansen, A. Sakaris, S.H. Min, S. Chattopadhyay, E. Tsai, C. Sandoval, R. Zhao, M.H. Akabas, and I.D. Goldman. (2006). Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell 127: 917-928. 17129779
Quistgaard, E.M., C. Löw, P. Moberg, and P. Nordlund. (2013). Metal-mediated crystallization of the xylose transporter XylE from Escherichia coli in three different crystal forms. J Struct Biol 184: 375-378. 24060988
Radestock, S. and L.R. Forrest. (2011). The alternating-access mechanism of MFS transporters arises from inverted-topology repeats. J. Mol. Biol. 407: 698-715. 21315728
Rajamohan, G., V.B. Srinivasan, and W.A. Gebreyes. (2010). Molecular and functional characterization of a novel efflux pump, AmvA, mediating antimicrobial and disinfectant resistance in Acinetobacter baumannii. J Antimicrob Chemother 65: 1919-1925. 20573661
Ramìrez, S., R. Moreno, O. Zafra, P. Castàn, C. Vallès, and J. Berenguer. (2000). Two nitrate/nitrite transporters are encoded within the mobilizable plasmid for nitrate respiration of Thermus thermophilus HB8. J. Bacteriol. 182: 2179-2183. 10735860
Ramon-Garcia S., Martin C., Thompson CJ. and Ainsa JA. (2009). Role of the Mycobacterium tuberculosis P55 efflux pump in intrinsic drug resistance, oxidative stress responses, and growth. Antimicrob Agents Chemother. 53(9):3675-82. 19564371
Rani, M., S. Raj, V. Dayaman, M. Kumar, M. Dua, and A.K. Johri. (2016). Functional Characterization of a Hexose Transporter from Root Endophyte Piriformospora indica. Front Microbiol 7: 1083. 27499747
Rappold, P.M., M. Cui, A.S. Chesser, J. Tibbett, J.C. Grima, L. Duan, N. Sen, J.A. Javitch, and K. Tieu. (2011). Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3. Proc. Natl. Acad. Sci. USA 108: 20766-20771. 22143804
Raymond-Bouchard I., Carroll CS., Nesbitt JR., Henry KA., Pinto LJ., Moinzadeh M., Scott JK. and Moore MM. (2012). Structural requirements for the activity of the MirB ferrisiderophore transporter of Aspergillus fumigatus. Eukaryot Cell. 11(11):1333-44. 22903978
Reihl, P. and J. Stolz. (2005). The monocarboxylate transporter homolog Mch5p catalyzes riboflavin (vitamin B2) uptake in Saccharomyces cerevisiae. J. Biol. Chem. 280: 39809-39817. 16204239
Reinders, A., J.A. Panshyshyn, and J.M. Ward. (2005). Analysis of transport activity of Arabidopsis sugar alcohol permease homolog AtPLT5. J. Biol. Chem. 280: 1594-1602. 15525644
Remy, E., T.R. Cabrito, R.A. Batista, M.A. Hussein, M.C. Teixeira, A. Athanasiadis, I. Sá-Correia, and P. Duque. (2014). Intron retention in the 5''UTR of the novel ZIF2 transporter enhances translation to promote zinc tolerance in arabidopsis. PLoS Genet 10: e1004375. 24832541
Ren F., Zhao CZ., Liu CS., Huang KL., Guo QQ., Chang LL., Xiong H. and Li XB. (2014). A Brassica napus PHT1 phosphate transporter, BnPht1;4, promotes phosphate uptake and affects roots architecture of transgenic Arabidopsis. Plant Mol Biol. 86(6):595-607. 25194430
Reynes, J.P., T. Calmels, D. Drocourt, and G. Tiraby. (1988). Cloning, expression in Escherichia coli and nucleotide sequence of a tetracycline-resistance gene from Streptomyces rimosus. J. Gen. Microbiol. 134: 585-598. 3053973
Rizwan, A.N., W. Krick, G. Burckhardt. (2007). The chloride dependence of the human organic anion transporter 1 (hOAT1) is blunted by mutation of a single amino acid. J. Biol. Chem. 282: 13402-13409. 17353191
Roca, I., S. Marti, P. Espinal, P. Martínez, I. Gibert, and J. Vila. (2009). CraA, a major facilitator superfamily efflux pump associated with chloramphenicol resistance in Acinetobacter baumannii. Antimicrob. Agents Chemother. 53: 4013-4014. 19581458
Rodionov, D.A., A.G. Vitreschak, A.A. Mironov, and M.S. Gelfand. (2002). Comparative genomics of thiamin biosynthesis in procaryotes. New genes and regulatory mechanisms. J. Biol. Chem. 277: 48949-48959. 12376536
Rodionov, D.A., C. Yang, X. Li, I.A. Rodionova, Y. Wang, A.Y. Obraztsova, O.P. Zagnitko, R. Overbeek, M.F. Romine, S. Reed, J.K. Fredrickson, K.H. Nealson, and A.L. Osterman. (2010). Genomic encyclopedia of sugar utilization pathways in the Shewanella genus. BMC Genomics 11: 494. 20836887
Rodionov, D.A., P. Hebbeln, A. Eudes, J. ter Beek, I.A. Rodionova, G.B. Erkens, D.J. Slotboom, M.S. Gelfand, A.L. Osterman, A.D. Hanson, and T. Eitinger. (2009). A novel class of modular transporters for vitamins in prokaryotes. J. Bacteriol. 191: 42-51. 18931129
Rodionov, D.A., X. Li, I.A. Rodionova, C. Yang, L. Sorci, E. Dervyn, D. Martynowski, H. Zhang, M.S. Gelfand, and A.L. Osterman. (2008). Transcriptional regulation of NAD metabolism in bacteria: genomic reconstruction of NiaR (YrxA) regulon. Nucleic Acids Res 36: 2032-2046. 18276644
Rodrigues, L., J. Ramos, I. Couto, L. Amaral, and M. Viveiros. (2011). Ethidium bromide transport across Mycobacterium smegmatis cell-wall: correlation with antibiotic resistance. BMC Microbiol 11: 35. 21332993
Rodriguez-Contreras, D., H. Aslan, X. Feng, K. Tran, P.A. Yates, S. Kamhawi, and S.M. Landfear. (2015). Regulation and biological function of a flagellar glucose transporter in Leishmania mexicana: a potential glucose sensor. FASEB J. 29: 11-24. 25300620
Roshanbin, S., F.A. Lindberg, E. Lekholm, M.M. Eriksson, E. Perland, J. Åhlund, A. Raine, and R. Fredriksson. (2016). Histological characterization of orphan transporter MCT14 (SLC16A14) shows abundant expression in mouse CNS and kidney. BMC Neurosci 17: 43. 27364523
Rottmann, T., W. Zierer, C. Subert, N. Sauer, and R. Stadler. (2016). STP10 encodes a high-affinity monosaccharide transporter and is induced under low-glucose conditions in pollen tubes of Arabidopsis. J Exp Bot. [Epub: Ahead of Print] 26893494
Ruiz-Pavón, L., P.M. Karlsson, J. Carlsson, D. Samyn, B. Persson, B.L. Persson, and C. Spetea. (2010). Functionally important amino acids in the Arabidopsis thylakoid phosphate transporter: homology modeling and site-directed mutagenesis. Biochemistry 49: 6430-6439. 20565143
Ryu, N., B. Sagong, H.J. Park, M.A. Kim, K.Y. Lee, J.Y. Choi, and U.K. Kim. (2016). Screening of the SLC17A8 gene as a causative factor for autosomal dominant non-syndromic hearing loss in Koreans. BMC Med Genet 17: 6. 26797701
Sa-Nogueira I. and Ramos S.S. (1997). Cloning, functional analysis, and transcriptional regulation of the Bacillus subtilis araE gene involved in L-arabinose utilization. J. of Bacteriol. 179:7705-7711. 9401028
Said, H.M., K. Van Voorhis, F.K. Ghishan, N. Abumurad, W. Nylander, and R. Redha. (1989). Transport characteristics of glutamine in human intestinal brush-border membrane vesicles. Am. J. Physiol. 256: G240-245. 2492158
Saier, M.H., Jr, D.L. Wentzel, B.U. Feucht, and J.J. Judice. (1975). A transport system for phosphoenolpyruvate, 2-phosphoglycerate, and 3-phosphoglycerate in Salmonella typhimurium. J. Biol. Chem. 250: 5089-5096. 238977
Saitoh H., Hirabuchi A., Fujisawa S., Mitsuoka C., Terauchi R. and Takano Y. (2014). MoST1 encoding a hexose transporter-like protein is involved in both conidiation and mycelial melanization of Magnaporthe oryzae. FEMS Microbiol Lett. 352(1):104-13. 24372780
Sakamoto, T., K. Inoue-Sakamoto, and D.A. Bryant. (1999). A novel nitrate/nitrite permease in the marine cyanobacterium Synechococcus sp. strain PCC 7002. J. Bacteriol. 181: 7363-7372. 10572142
Santiviago, C.A., J.A. Fuentes, S.M. Bueno, A.N. Trombert, A.A. Hildago, L.T. Socias, P. Youderian, and G.C. Mora. (2002). The Salmonella entrica sv. Typhimurium smvA, yddG and ompD (porin) genes are required for the efficient efflux of methyl viologen. Mol. Microbiol. 46: 687-698. 12410826
Sanyal, S. and M. Ramaswami. (2002). Spinsters, synaptic defects, and amaurotic idiocy. Neuron 36: 335-338. 12408836
Sargiacomo, M., M. Valtieri, M. Gabbianelli, E. Pelosi, U. Testa, A. Camagna, and C. Peschle. (1991). Pure human hematopoietic progenitors: direct inhibitory effect of transforming growth factors-beta 1 and -beta 2. Ann. N.Y. Acad. Sci. 628: 84-91. 2069325
Sasaki, M. and Y. Kurusu. (2004). Analysis of spontaneous base substitutions generated in mutator strains of Bacillus subtilis. FEMS Microbiol. Lett. 234: 37-42. 15109717
Sato, M. and M. Mueckler. (1999). A conserved amino acid motif (R-X-G-R-R) in the Glut1 glucose transporter is an important determinant of membrane topology. J. Biol. Chem. 274: 24721-24725. 10455140
Sauer, J.-D., Bachman, M.A., and Swanson, M.S. (2005). The phagosomal transporter A couples threonine acquisition to differentiation and replication of Legionella pneumophila in macrophages. Proc. Natl. Acad. Sci. USA 102: 9924-9929. 15998735
Savalas, L.R., B. Gasnier, M. Damme, T. Lübke, C. Wrocklage, C. Debacker, A. Jézégou, T. Reinheckel, A. Hasilik, P. Saftig, and B. Schröder. (2011). Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L. Biochem. J. 439: 113-128. 21692750
Sawada, K., N. Echigo, N. Juge, T. Miyaji, M. Otsuka, H. Omote, A. Yamamoto, and Y. Moriyama. (2008). Identification of a vesicular nucleotide transporter. Proc. Natl. Acad. Sci. USA. 105: 5683-5686. 18375752
Schaedler TA. and van Veen HW. (2010). A flexible cation binding site in the multidrug major facilitator superfamily transporter LmrP is associated with variable proton coupling. FASEB J. 24(10):3653-61. 20472749
Scheepers, A., S. Schmidt, A. Manolescu, C.I. Cheeseman, A. Bell, C. Zahn, H.G. Joost, and A. Schürmann. (2005). Characterization of the human SLC2A11 (GLUT11) gene: alternative promoter usage, function, expression, and subcellular distribution of three isoforms, and lack of mouse orthologue. Mol. Membr. Biol. 22: 339-351. 16154905
Schilling, S. and C. Oesterhelt. (2007). Structurally reduced monosaccharide transporters in an evolutionarily conserved red alga. Biochem. J. 406: 325-331. 17497961
Schmitt, B.M. and H. Koepsell. (2005). Alkali cation binding and permeation in the rat organic cation transporter rOCT2. J. Biol. Chem. 280: 24481-24490. 15878879
Schneider, S., A. Schneidereit, K.R. Konrad, M.R. Hajirezaei, M. Gramann, R. Hedrich, and N. Sauer. (2006). Arabidopsis INOSITOL TRANSPORTER4 mediates high-affinity H+ symport of myoinositol across the plasma membrane. Plant Physiol. 141:565-577. 16603666
Schneider, S., A. Schneidereit, P. Udvardi, U. Hammes, M. Gramann, P. Dietrich, and N. Sauer. (2007). Arabidopsis INOSITOL TRANSPORTER2 Mediates H+-Symport of Different Inositol Epimers and Derivatives across the Plasma Membrane. Plant Physiol. 145: 1395-1407. 17951450
Schneider, S., D. Beyhl, R. Hedrich, and N. Sauer. (2008). Functional and Physiological Characterization of Arabidopsis INOSITOL TRANSPORTER1, a Novel Tonoplast-Localized Transporter for myo-Inositol. Plant Cell 20: 1073-1087. 18441213
Schneidereit, A., J. Scholz-Starke, N. Sauer, and M. Büttner. (2005). AtSTP11, a pollen tube-specific monosaccharide transporter in Arabidopsis. Planta.221: 48-55. 15565288
Scholz-Starke J., M. Büttner, and N. Sauer. (2003). AtSTP6, a new pollen-specific H+-monosaccharide symporter from Arabidopsis. Plant Physiol. 131:70-77. 12529516
Schubbe, S., M. Kube, A. Scheffel, C. Wawer, U. Heyen, A. Meyerdierks, M.H. Madkour, F. Mayer, R. Reinhardt, and D. Schüler. (2003). Characterization of a spontaneous nonmagnetic mutant of Magnetospirillum gryphiswaldense reveals a large deletion comprising a putative magnetosome island. J. Bacteriol. 185: 5779–5790. 13129949
Schuldiner, S., A. Shirvan, and M. Linial. (1995). Vesicular neurotransmitter transporters: from bacteria to humans. Physiol. Rev. 75: 369-392. 7724667
Schulz, A., D. Beyhl, I. Marten, A. Wormit, E. Neuhaus, G. Poschet, M. Büttner, S. Schneider, N. Sauer, and R. Hedrich. (2011). Proton-driven sucrose symport and antiport are provided by the vacuolar transporters SUC4 and TMT1/2. Plant J. 68: 129-136. 21668536
Schussler, A., H. Martin, D. Cohen, M. Fitz, and D. Wipf. (2006). Characterization of a carbohydrate transporter from symbiotic glomeromycotan fungi. Nature 444: 933-936. 17167486
Schweizer U. and Kohrle J. (2013). Function of thyroid hormone transporters in the central nervous system. Biochim Biophys Acta. 1830(7):3965-73. 22890106
Schwöppe, C., H.H. Winkler, and H.E. Neuhaus. (2002). Properties of the glucose-6-phosphate transporter from Chlamydia pneumoniae (HPTcp) and the glucose-6-phosphate sensor from Escherichia coli (UhpC). J. Bacteriol. 184: 2108-2115. 11914341
Seeger, C., C. Poulsen, and G. Dandanell. (1995). Identification and characterization of genes (xapA, xapB, and xapR) involved in xanthosine catabolism in Escherichia coli. J. Bacteriol. 177: 5506-5516. 7559336
Sekine, T., S.H. Cha, M. Tsuda, N. Apiwattanakul, N. Nakajima, Y. Kanai, and H. Endou. (1998). Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 429: 179-182. 9650585
Seol, W. and A.J. Shatkin. (1992). Escherichia coli α-ketoglutarate permease is a constitutively expressed proton symporter. J. Biol. Chem. 267: 6409-6413. 1556144
Seol, W. and A.J. Shatkin. (1992). Site-directed mutants of Escherichia coli α-ketoglutarate permease (KgtP). Biochemistry 31: 3550-3554. 1554735
Serrano-Saiz, E., R.J. Poole, T. Felton, F. Zhang, E.D. De La Cruz, and O. Hobert. (2013). Modular control of glutamatergic neuronal identity in C. elegans by distinct homeodomain proteins. Cell 155: 659-673. 24243022
Sharifi, A., M. Kousi, C. Sagné, G.C. Bellenchi, L. Morel, M. Darmon, H. Hulková, R. Ruivo, C. Debacker, S. El Mestikawy, M. Elleder, A.E. Lehesjoki, A. Jalanko, B. Gasnier, and A. Kyttälä. (2010). Expression and lysosomal targeting of CLN7, a major facilitator superfamily transporter associated with variant late-infantile neuronal ceroid lipofuscinosis. Hum Mol Genet 19: 4497-4514. 20826447
Shayeghi, M., G.O. Latunde-Dada, J.S. Oakhill, A.H. Laftah, K. Takeuchi, N. Halliday, Y. Khan, A. Warley, F.E. McCann, R.C. Hider, D.M. Frazer, G.J. Anderson, C.D. Vulpe, R.J. Simpson, and A.T. McKie. (2005). Identification of an intestinal heme transporter. Cell 122: 789-801. 16143108
Sheremet, A.S., S.V. Gronskiy, R.A. Akhmadyshin, A.E. Novikova, V.A. Livshits, R.S. Shakulov, and N.P. Zakataeva. (2011). Enhancement of extracellular purine nucleoside accumulation by Bacillus strains through genetic modifications of genes involved in nucleoside export. J Ind Microbiol Biotechnol 38: 65-70. 20814730
Shim, M.S., J.Y. Kim, K.H. Lee, H.K. Jung, B.A. Carlson, X.M. Xu, D.L. Hatfield, and B.J. Lee. (2011). l(2)01810 is a novel type of glutamate transporter that is responsible for megamitochondrial formation. Biochem. J. 439: 277-286. 21728998
Shimazu, M., T. Sekito, K. Akiyama, Y. Ohsumi, and Y. Kakinuma. (2005). A family of basic amino acid transporters of the vacuolar membrane from Saccharomyces cerevisiae. J. Biol. Chem. 280: 4851-4857. 15572352
Shin DS., Zhao R., Fiser A. and Goldman DI. (2012). Functional roles of the A335 and G338 residues of the proton-coupled folate transporter (PCFT-SLC46A1) mutated in hereditary folate malabsorption. Am J Physiol Cell Physiol. 303(8):C834-42. 22843796
Shin, D.S., R. Zhao, E.H. Yap, A. Fiser, and I.D. Goldman. (2012). A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding. Am. J. Physiol. Cell Physiol. 302: C1405-1412. 22345511
Shin, D.S., S.H. Min, L. Russell, R. Zhao, A. Fiser, and I.D. Goldman. (2010). Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption. Blood 116: 5162-5169. 20805364
Shin, H.J., N. Anzai, A. Enomoto, X. He, do K. Kim, H. Endou, and Y. Kanai. (2007). Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate. Hepatology. 45: 1046-1055. 17393504
Shinnick, S.G., S.A. Perez, and M.F. Varela. (2003). Altered substrate selection of the melibiose transporter (MelY) of Enterobacter cloacae involving point mutations in Leu-88, Leu-91, and Ala-182 that confer enhanced maltose transport. J. Bacteriol. 185: 3672-3677. 12775706
Shiraya, K., T. Hirata, R. Hatano, S. Nagamori, P. Wiriyasermkul, P. Jutabha, M. Matsubara, S. Muto, H. Tanaka, S. Asano, N. Anzai, H. Endou, A. Yamada, H. Sakurai, and Y. Kanai. (2010). A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules. J. Biol. Chem. 285: 22141-22151. 20448048
Sim, S.Y., E.J. Hong, Y. Kim, and H.S. Lee. (2014). Analysis of cepA encoding an efflux pump-like protein in Corynebacterium glutamicum. J Microbiol 52: 278-283. 24535744
Siskind, L.J., L. Feinstein, T. Yu, J.S. Davis, D. Jones, J. Choi, J.E. Zuckerman, W. Tan, R.B. Hill, J.M. Hardwick, and M. Colombini. (2008). Anti-apoptotic Bcl-2 Family proteins disassemble ceramide channels. J. Biol. Chem. 283: 6622-6630. 18171672
Skelly, P.J., J.W. Kim, J. Cunningham, and C.B. Shoemaker. (1994). Cloning, characterization, and functional expression of cDNAs encoding glucose transporter proteins from the human parasite Schistosoma mansoni. J. Biol. Chem. 269: 4247-4253. 8307988
Slavetinsky, C.J., A. Peschel, and C.M. Ernst. (2012). Alanyl-phosphatidylglycerol and lysyl-phosphatidylglycerol are translocated by the same MprF flippases and have similar capacities to protect against the antibiotic daptomycin in Staphylococcus aureus. Antimicrob. Agents Chemother. 56: 3492-3497. 22491694
Sloothaak, J., M. Schilders, P.J. Schaap, and L.H. de Graaff. (2014). Overexpression of the Aspergillus niger GatA transporter leads to preferential use of D-galacturonic acid over D-xylose. AMB Express 4: 66. 25177540
Smirnova, I., V. Kasho, and H.R. Kaback. (2011). Lactose permease and the alternating access mechanism. Biochemistry 50: 9684-9693. 21995338
Smirnova, I., V. Kasho, J. Sugihara, and H.R. Kaback. (2011). Opening the periplasmic cavity in lactose permease is the limiting step for sugar binding. Proc. Natl. Acad. Sci. USA 108: 15147-15151. 21896727
Smit, A., S.G. Moses, I.S. Pretorius, and R.R. Cordero Otero. (2008). The Thr505 and Ser557 residues of the AGT1-encoded α- glucoside transporter are critical for maltotriose transport in Saccharomyces cerevisiae. J. Appl. Microbiol. 104: 1103-1111. 18179544
Smith, K.P., S. Kumar, and M.F. Varela. (2009). Identification, cloning, and functional characterization of EmrD-3, a putative multidrug efflux pump of the major facilitator superfamily from Vibrio cholerae O395. Arch. Microbiol. 191: 903-911. 19876617
Soares-Silva, I., J. Sá-Pessoa, V. Myrianthopoulos, E. Mikros, M. Casal, and G. Diallinas. (2011). A substrate translocation trajectory in a cytoplasm-facing topological model of the monocarboxylate/H⁺ symporter Jen1p. Mol. Microbiol. 81: 805-817. 21651629
Soo, V.W., P. Hanson-Manful, and W.M. Patrick. (2011). Artificial gene amplification reveals an abundance of promiscuous resistance determinants in Escherichia coli. Proc. Natl. Acad. Sci. USA 108: 1484-1489. 21173244
Srinivas, S.R., P.D. Prasad, N.S. Umapathy, V. Ganapathy, and P.S. Shekhawat. (2007). Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB0,+. Am. J. Physiol. Gastrointest Liver Physiol 293: G1046-1053. 17855766
Stadler, R., M. Büttner, P. Ache, R. Hedrich, N. Ivashikina, M. Melzer, S.M. Shearson, S.M. Smith, and N. Sauer. (2003). Diurnal and light-regulated expression of AtSTP1 in guard cells of Arabidopsis. Plant Physiol. 133: 528-537. 12972665
Stasyk, O.G., M.M. Maidan, O.V. Stasyk, P. Van Dijck, J.M. Thevelein, and A.A. Sibirny. (2008). Identification of hexose transporter-like sensor HXS1 and functional hexose transporter HXT1 in the methylotrophic yeast Hansenula polymorpha. Eukaryot. Cell. 7(4): 735-746. 18310355
Staub, J.M., L. Brand, M. Tran, Y. Kong, and S.G. Rogers. (2012). Bacterial glyphosate resistance conferred by overexpression of an E. coli membrane efflux transporter. J Ind Microbiol Biotechnol 39: 641-647. 22089966
Staubitz, P., H. Neumann, T. Schneider, I. Wiedemann, and A. Peschel. (2004). MprF-mediated biosynthesis of lysylphosphatidylglycerol, an important determinant in staphylococcal defensin resistance. FEMS Microbiol. Lett. 231: 67-71. 14769468
Stolz, J. (2003). Isolation and characterization of the plasma membrane biotin transporter from Schizosaccharomyces pombe. Yeast. 20: 221-231. 12557275
Stolz, J., H.J. Wöhrmann, and C. Vogl. (2005). Amiloride uptake and toxicity in fission yeast are caused by the pyridoxine transporter encoded by bsu1+ (car1+). Eukaryot. Cell. 4: 319-326. 15701794
Stolz, J., T. Caspari, A.M. Carr, N. Sauer. (2004). Cell division defects of Schizosaccharomyces pombe liz1- mutants are caused by defects in pantothenate uptake. Euk. Cell 3: 406-412. 15075270
Stolz, J., U. Hoja, S, Meier, N. Sauer, and E. Schweizer. (2000). Identification of the plasma membrane H+-biotin symporter of Saccharomyces cerevisiae by rescue of a fatty acid-auxotrophic mutant. J. Biol. Chem. 274: 18741-18746. 10373489
Sturm, A., V. Gorboulev, D. Gorbunov, T. Keller, C. Volk, B.M. Schmitt, P. Schlachtbauer, G. Ciarimboli, and H. Koepsell. (2007). Identification of cysteines in rat organic cation transporters rOCT1 (C322, C451) and rOCT2 (C451) critical for transport activity and substrate affinity. Am. J. Physiol. Renal Physiol 293: F767-779. 17567940
Su X. and Tsang JS. (2013). Existence of a robust haloacid transport system in a Burkholderia species bacterium. Biochim Biophys Acta. 1828(2):187-92. 23022134
Su, X., R. Li, K.F. Kong, and J.S. Tsang. (2016). Transport of haloacids across biological membranes. Biochim. Biophys. Acta. 1858: 3061-3070. 27668346
Subramanian, V.S., J.S. Marchant, and H.M. Said. (2008). Apical membrane targeting and trafficking of the human proton-coupled transporter in polarized epithelia. Am. J. Physiol. Cell Physiol. 294: C233-240. 18003745
Sugimoto, N., T. Iwaki, S. Chardwiriyapreecha, M. Shimazu, M. Kawano, T. Sekito, K. Takegawa, and Y. Kakinuma. (2011). Atg22p, a vacuolar membrane protein involved in the amino acid compartmentalization of Schizosaccharomyces pombe. Biosci. Biotechnol. Biochem. 75: 385-387. 21307582
Sun, L., X. Zeng, C. Yan, X. Sun, X. Gong, Y. Rao, and N. Yan. (2012). Crystal structure of a bacterial homologue of glucose transporters GLUT1-4. Nature 490: 361-366. 23075985
Sun, Y. and C.K. Vanderpool. (2011). Regulation and function of Escherichia coli sugar efflux transporter A (SetA) during glucose-phosphate stress. J. Bacteriol. 193: 143-153. 20971900
Suzawa, K., A. Yukita, T. Hayata, T. Goto, H. Danno, T. Michiue, K.W. Cho, and M. Asashima. (2007). Xenopus glucose transporter 1 (xGLUT1) is required for gastrulation movement in Xenopus laevis. Int J Dev Biol 51: 183-190. 17486538
Swain, K., I. Casabon, L.D. Eltis, and W.W. Mohn. (2012). Two transporters essential for reassimilation of novel cholate metabolites by Rhodococcus jostii RHA1. J. Bacteriol. 194: 6720-6727. 23024344
Sweet, D.H. and J.B. Pritchard. (1999). rOCT2 is a basolateral potential-driven carrier, not an organic cation/proton exchanger. Am. J. Physiol. 277: F890-898. 10600936
Tahlan, K., S.K. Ahn, A. Sing, T.D. Bodnaruk, A.R. Willems, A.R. Davidson, and J.R. Nodwell. (2007). Initiation of actinorhodin export in Streptomyces coelicolor. Mol. Microbiol. 63: 937-940. 17338074
Tailor, C.S., B.J. Willett, and D. Kabat. (1999). A putatve cell surface receptor for anemia-inducing feline leukemia virus subgroup C is a member of a transporter superfamily. Virology 73: 6500-6505. 10400745
Takanaga H. and Frommer WB. (2010). Facilitative plasma membrane transporters function during ER transit. FASEB J. 24(8):2849-58. 20354141
Tamai, I., R. Ohashi, J. Nezu, H. Yabuuchi, A. Oku, M. Shimane, Y. Sai, and A. Tsuji. (1998). Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. J. Biol. Chem. 273: 20378-20382. 9685390
Tan, P.K., T.M. Ostertag, and J.N. Miner. (2016). Mechanism of high affinity inhibition of the human urate transporter URAT1. Sci Rep 6: 34995. 27713539
Tanabe, T., T. Funahashi, H. Nakao, S.-I. Miyoshi, S. Shinoda, and S. Yamamoto. (2003). Identification and characterization of genes required for biosynthesis and transport of the siderophore vibrioferrin in Vibrio parahaemolyticus. J. Bacteriol. 185: 6938-6949. 14617658
Tang, G., B. Jiang, Y. Huang, M. Fu, L. Wu, and R. Wang. (2011). Identification of a novel bacterial k(+) channel. J. Membr. Biol. 242: 153-164. 21744086
Tavoulari, S. and S. Frillingos. (2008). Substrate selectivity of the melibiose permease (MelY) from Enterobacter cloacae. J. Mol. Biol. 376: 681-693. 18177889
Teijeira, F., R.V. Ullán, S.M. Guerra, C. García-Estrada, I. Vaca, and J.F. Martín. (2009). The transporter CefM involved in translocation of biosynthetic intermediates is essential for cephalosporin production. Biochem. J. 418: 113-124. 18840096
Tenreiro, S., P.A. Nunes, C.A. Viegas, M.S. Neves, M.C. Teixeira, M.G. Cabral, and I. Sá-Correia. (2002). AQR1 gene (ORF YNL065w) encodes a plasma membrane transporter of the major facilitator superfamily that confers resistance to short-chain monocarboxylic acids and quinidine in Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 292: 741-748. 11922628
Teranishi, Y., M. Inoue, N.G. Yamamoto, T. Kihara, B. Wiehager, T. Ishikawa, B. Winblad, S. Schedin-Weiss, S. Frykman, and L.O. Tjernberg. (2015). Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage. FEBS J. 282: 3438-3451. 26094765
Thompson, S.A., E.V. Maani, A.H. Lindell, C.J. King, and J.V. McArthur. (2007). Novel tetracycline resistance determinant isolated from an environmental strain of Serratia marcescens. Appl. Environ. Microbiol. 73: 2199-2206. 17308196
Tirosh, O., N. Sigal, A. Gelman, N. Sahar, N. Fluman, S. Siemion, and E. Bibi. (2012). Manipulating the drug/proton antiport stoichiometry of the secondary multidrug transporter MdfA. Proc. Natl. Acad. Sci. USA 109: 12473-12478. 22802625
Tomitori, H., K. Kashiwagi, K. Sakata, Y. Kakinuma, and K. Igarashi. (1999). Identification of a gene for a polyamine transport protein in yeast. J. Biol. Chem. 274: 3265-3267. 9920864
Truernit, E., J. Schmid, P. Epple, J. Illig, and N. Sauer. (1996). The sink-specific and stress-regulated Arabidopsis STP4 gene: enhanced expression of a gene encoding a monosaccharide transporter by wounding, elicitors, and pathogen challenge. Plant Cell 8: 2169-2182. 8989877
Truernit, E., R. Stadler, K. Baier, and N. Sauer. (1999). A male gametophyte-specific monosaccharide transporter in Arabidopsis. Plant J. 17: 191-201. 10074716
Truong, D.M., G. Kaler, A. Khandelwal, P.W. Swaan, and S.K. Nigam. (2008). Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination. J. Biol. Chem. 283(13): 8654-8663. 18174163
Truong-Bolduc, Q.C., J. Strahilevitz, and D.C. Hooper. (2006). NorC, a new efflux pump regulated by MgrA of Staphylococcus aureus. Antimicrob. Agents Chemother. 50: 1104-1107. 16495280
Truong-Bolduc, Q.C., P.M. Dunman, J. Strahilevitz, S.J. Projan, and D.C. Hooper. (2005). MgrA is a multiple regulator of two new efflux pumps in Staphylococcus aureus. J. Bacteriol. 187: 2395-2405. 15774883
Tse, Y.M., M. Yu, and J.S. Tsang. (2009). Topological analysis of a haloacid permease of a Burkholderia sp. bacterium with a PhoA-LacZ reporter. BMC Microbiol 9: 233. 19878597
Tsuchida, H., N. Anzai, H.J. Shin, M.F. Wempe, P. Jutabha, A. Enomoto, S.H. Cha, T. Satoh, M. Ishida, H. Sakurai, and H. Endou. (2010). Identification of a novel organic anion transporter mediating carnitine transport in mouse liver and kidney. Cell Physiol Biochem 25: 511-522. 20332632
Turner, M.S. and J.D. Helmann. (2000). Mutations in multidrug efflux homologs, sugar isomerases, and antimicrobial biosynthesis genes differentially elevate activity of the σX and σW factors in Bacillus subtilis. J. Bacteriol. 182: 5202-5210. 10960106
Uemura, T., K. Tachihara, H. Tomitori, K. Kashiwagi, K. Igarashi. (2005). Characteristics of the polyamine transporter TPO1 and regulation of its activity and cellular localization by phosphorylation. J. Biol. Chem. 280: 9646-9652. 15637075
Uldry, M., M. Ibberson, J.D. Horisberger, J.Y. Chatton, B.M. Riederer, and B. Thorens. (2001). Identification of a mammalian H+-myo-inositol symporter expressed predominantly in the brain. EMBO J. 20: 4467-4477. 11500374
Uldry, M., M. Ibberson, M. Hosokawa, and B. Thorens. (2002). GLUT2 is a high affinity glucosamine transporter. FEBS Lett. 524: 199-203. 12135767
Ullán, R.V., G. Liu, J. Casqueiro, S. Gutiérrez, O. Bañuelos, and J.F. Martín. (2002). The cefT gene of Acremonium chrysogenum C10 encodes a putative multidrug efflux pump protein that significantly increases cephalosporin C production. Mol. Genet. Genomics 267: 673-683. 12172807
Unkles SE., Karabika E., Symington VF., Cecile JL., Rouch DA., Akhtar N., Cromer BA. and Kinghorn JR. (2012). Alanine scanning mutagenesis of a high-affinity nitrate transporter highlights the requirement for glycine and asparagine residues in the two nitrate signature motifs. Biochem J. 447(1):35-42. 22738143
Unkles, S.E., K.L. Hawker, C. Grieve, E.I. Campbell, P. Montague, and J.R. Kinghorn. (1991). crnA encodes a nitrate transporter in Aspergillus nidulans. Proc. Natl. Acad. Sci. USA 88: 204-208. 1986367
Unkles, S.E., V.F. Symington, Z. Kotur, Y. Wang, M.Y. Siddiqi, J.R. Kinghorn, and A.D. Glass. (2011). Physiological and biochemical characterization of AnNitA, the Aspergillus nidulans high-affinity nitrite transporter. Eukaryot. Cell. 10: 1724-1732. 22021238
Uwai, Y., Y. Ozeki, T. Isaka, H. Honjo, and K. Iwamoto. (2011). Inhibitory effect of caffeic acid on human organic anion transporters hOAT1 and hOAT3: a novel candidate for food-drug interaction. Drug Metab Pharmacokinet 26: 486-493. 21697612
Valmeekam, V., Y.L. Loh, and M.J. San Francisco. (2001). Control of exuT activity for galacturonate transport by the negative regulator ExuR in Erwinia chrysanthemi EC16. Mol. Plant Microbe Interact. 14: 816-820. 11386378
Van Camp, B.M., R.R. Crow, Y. Peng, and M.F. Varela. (2007). Amino acids that confer transport of raffinose and maltose sugars in the raffinose permease (RafB) of Escherichia coli as implicated by spontaneous mutations at Val-35, Ser-138, Ser-139, Gly-389 and Ile-391. J. Membr. Biol. 220: 87-95. 18008022
van Wezel, G.P., K. Mahr, M. König, B.A. Traag, E.F. Pimentel-Schmitt, A. Willimek, and F. Titgemeyer. (2005). GlcP constitutes the major glucose uptake system of Streptomyces coelicolor A3(2). Mol. Microbiol. 55: 624-636. 15659175
Vardy, E., S. Steiner-Mordoch, and S. Schuldiner. (2005). Characterization of bacterial drug antiporters homologous to mammalian neurotransmitter transporters. J. Bacteriol. 187: 7518-7525. 16237035
Västermark, A. and M.H. Saier. (2014). Major Facilitator Superfamily (MFS) evolved without 3-transmembrane segment unit rearrangements. Proc. Natl. Acad. Sci. USA 111: E1162-1163. 24567407
Västermark, A., B. Lunt, and M. Saier. (2014). Major facilitator superfamily porters, LacY, FucP and XylE of Escherichia coli appear to have evolved positionally dissimilar catalytic residues without rearrangement of 3-TMS repeat units. J. Mol. Microbiol. Biotechnol. 24: 82-90. 24603210
Verheijen, F.W., E. Verbeek, N. Aula, C.E. Beerens, A.C. Havelaar, M. Joosse, L. Peltonen, R. Aula, H. Galjaard, P.J. van der Spek, and G.M. Mancini. (1999). A new gene, encoding an anion transporter, is mutated in sialic acid storage diseases. Nature Genet. 23: 462-465. 10581036
Visser, W.E., N.J. Philp, T.B. van Dijk, W. Klootwijk, E.C. Friesema, J. Jansen, P.W. Beesley, A.G. Ianculescu, and T.J. Visser. (2009). Evidence for a homodimeric structure of human monocarboxylate transporter 8. Endocrinology 150: 5163-5170. 19797118
Visser, W.F., C.W. van Roermund, L. Ijlst, H.R. Waterham, and R.J. Wanders. (2007). Metabolite transport across the peroxisomal membrane. Biochem. J. 401: 365-375. 17173541
Vogl, C., C.M. Klein, A.F. Batke, M.E. Schweingruber, and J. Stolz. (2008). Characterization of Thi9, a novel thiamine (Vitamin B1) transporter from Schizosaccharomyces pombe. J. Biol. Chem. 283: 7379-7389. 18201975
Volkova M., Mandikova J., Barta P., Navratilova L., Laznickova A. and Trejtnar F. (2015). The in vivo disposition and in vitro transmembrane transport of two model radiometabolites of DOTA-conjugated receptor-specific peptides labelled with (177) Lu. J Labelled Comp Radiopharm. 58(13-14):483-9. 26526343
von Rozycki, T., M.R. Yen, E.E. Lende, and M.H. Saier, Jr. (2004). The YedZ family: possible heme binding proteins that can be fused to transporters and electron carriers. J. Mol. Microbiol. Biotechnol. 8: 129-140. 16088215
Walters, D.K., B.K. Arendt, and D.F. Jelinek. (2013). CD147 regulates the expression of MCT1 and lactate export in multiple myeloma cells. Cell Cycle 12: 3175-3183. 24013424
Wang C., Shen Y., Hou J., Suo F. and Bao X. (2013). An assay for functional xylose transporters in Saccharomyces cerevisiae. Anal Biochem. 442(2):241-8. 23928049
Wang M., Qi H., Li J., Xu Y. and Zhang H. (2015). Transmembrane transport of steviol glucuronide and its potential interaction with selected drugs and natural compounds. Food Chem Toxicol. 86:217-24. 26525112
Wang, C., L. Yang, A.A. Shah, E.S. Choi, and S.W. Kim. (2015). Dynamic interplay of multidrug transporters with TolC for isoprenol tolerance in Escherichia coli. Sci Rep 5: 16505. 26563610
Wang, C., X. Bao, Y. Li, C. Jiao, J. Hou, Q. Zhang, W. Zhang, W. Liu, and Y. Shen. (2015). Data set for cloning and characterization of heterologous transporters in Saccharomyces cerevisiae and identification of important amino acids for xylose utilization. Data Brief 4: 119-126. 26217774
Wang, J., T. Li, X. Wu, and Z. Zhao. (2014). Molecular cloning and functional analysis of a H+-dependent phosphate transporter gene from the ectomycorrhizal fungus Boletus edulis in southwest China. Fungal Biol 118: 453-461. 24863474
Wang, Q. and M.E. Morris. (2007). The role of monocarboxylate transporter 2 and 4 in the transport of γ-hydroxybutyric acid in mammalian cells. Drug Metab Dispos 35: 1393-1399. 17502341
Wang, Q., H. Li, and A.F. Post. (2000). Nitrate assimilation genes of the marine diazotrophic, filamentous cyanobacterium Trichodesmium sp. strain WH9601. J. Bacteriol. 182: 1764-1767. 10692386
Wang, W. and H.W. van Veen. (2012). Basic residues R260 and K357 affect the conformational dynamics of the major facilitator superfamily multidrug transporter LmrP. PLoS One 7: e38715. 22761697
Wang, W., A.A. Guffanti, Y. Wei, M. Ito, and T.A. Krulwich. (2000). Two types of Bacillus subtilis tetA(L) deletion strains reveal the physiological importance of TetA(L) in K+ acquisition as well as in Na+, alkali, and tetracycline resistance. J. Bacteriol. 182: 2088-2095. 10735849
Wang, X., R.I. Sarker, and P.C. Maloney. (2006). Analysis of substrate-binding elements in OxlT, the oxalate:formate antiporter of Oxalobacter formigenes. Biochemistry 45: 10344-10350. 16922510
Wang, Y., W. Li, Y. Siddiqi, V.F. Symington, J.R. Kinghorn, S.E. Unkles, and A.D. Glass. (2008). Nitrite transport is mediated by the nitrite-specific high-affinity NitA transporter and by nitrate transporters NrtA, NrtB in Aspergillus nidulans. Fungal Genet Biol 45: 94-102. 18024100
Wieczorke, R., S. Krampe, T. Weierstall, K. Freidel, C.P. Hollenberg, and E. Boles. (1999). Concurrent knock-out of at least 20 transporter genes is required to block uptake of hexoses in Saccharomyces cerevisiae. FEBS Lett. 464: 123-128. 10618490
Williams, P.A. and L.E. Shaw. (1997). mucK, a gene in Acinetobacter calcoaceticus ADP1 (BD413), encodes the ability to grow on exogenous cis,cis-muconate as the sole carbon source. J. Bacteriol. 179: 5935-5942. 9294455
Wilson MR., Kugel S., Huang J., Wilson LJ., Wloszczynski PA., Ye J., Matherly LH. and Hou Z. (2015). Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6. Biochem J. 469(1):33-44. 25877470
Wilson, M.C., D. Meredith, J.E. Fox, C. Manoharan, A.J. Davies, and A.P. Halestrap. (2005). Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). J. Biol. Chem. 280: 27213-27221. 15917240
Wilson, M.C., V.N. Jackson, C. Heddle, N.T. Price, H. Pilegaard, C. Juel, A. Bonen, I. Montgomery, O.F. Hutter, and A.P. Halestrap. (1998). Lactic acid efflux from white skeletal muscle is catalyzed by the monocarboxylate transporter isoform MCT3. J. Biol. Chem. 273: 15920-15926. 9632638
Wilson, M.R., Z. Hou, and L.H. Matherly. (2014). Substituted Cysteine Accessibility Reveals a Novel Transmembrane 2-3 Reentrant Loop and Functional Role for Transmembrane Domain 2 in the Human Proton-coupled Folate Transporter. J. Biol. Chem. 289: 25287-25295. 25053408
Wirth, E.K., S.Y. Sheu, J. Chiu-Ugalde, R. Sapin, M.O. Klein, I. Mossbrugger, L. Quintanilla-Martinez, M.H. de Angelis, H. Krude, T. Riebel, K. Rothe, J. Köhrle, K.W. Schmid, U. Schweizer, and A. Grüters. (2011). Monocarboxylate transporter 8 deficiency: altered thyroid morphology and persistent high triiodothyronine/thyroxine ratio after thyroidectomy. Eur J Endocrinol 165: 555-561. 21813593
Wirth, E.K., U. Schweizer, and J. Köhrle. (2014). Transport of thyroid hormone in brain. Front Endocrinol (Lausanne) 5: 98. 25009532
Wirth, J., F. Chopin, V. Santoni, G. Viennois, P. Tillard, A. Krapp, L. Lejay, F. Daniel-Vedele, and A. Gojon. (2007). Regulation of root nitrate uptake at the NRT2.1 protein level in Arabidopsis thaliana. J. Biol. Chem. 282: 23541-23552. 17573350
Witkowska K., Smith KM., Yao SY., Ng AM., O'Neill D., Karpinski E., Young JD. and Cheeseman CI. (2012). Human SLC2A9a and SLC2A9b isoforms mediate electrogenic transport of urate with different characteristics in the presence of hexoses. Am J Physiol Renal Physiol. 303(4):F527-39. 22647630
Wollack, J.B., B. Makori, S. Ahlawat, R. Koneru, S.C. Picinich, A. Smith, I.D. Goldman, A. Qiu, P.D. Cole, J. Glod, and B. Kamen. (2008). Characterization of folate uptake by choroid plexus epithelial cells in a rat primary culture model. J Neurochem 104(6): 1494-1503. 18086128
Wood, N.J., T. Alizadeh, D.J. Richardson, S.J. Ferguson, and J.W.B. Moir. (2002). Two domains of a dual-function NarK protein are required for nitrate uptake, the first step of denitrification in Paracoccus pantotrophus. Mol. Microbiol. 44: 157-170. 11967076
Woolley, R.C., G. Vediyappan, M. Anderson, M. Lackey, B. Ramasubramanian, B. Jiangping, T. Borisova, J.A. Colmer, A.N. Hamood, C.S. McVay, and J.A. Fralick. (2005). Characterization of the Vibrio cholerae vceCAB multiple-drug resistance efflux operon in Escherichia coli. J. Bacteriol. 187: 5500-5503. 16030246
Wright DJ. and Tate CG. (2015). Isolation and characterisation of transport-defective substrate-binding mutants of the tetracycline antiporter TetA(B). Biochim Biophys Acta. 1848(10 Pt A):2261-2270. 26143388
Wright, D.C. (2007). Mechanisms of calcium-induced mitochondrial biogenesis and GLUT4 synthesis. Appl Physiol Nutr Metab 32: 840-845. 18059607
Wright, M.B., E.A. Howell, and R.F. Gaber. (1996). Amino acid substitutions in membrane-spanning domains of Hol1, a member of the major facilitator superfamily of transporters, confer nonselective cation uptake in Saccharomyces cerevisiae. J. Bacteriol. 178: 7197-7205. 8955402
Wu, W., N. Jamshidi, S.A. Eraly, H.C. Liu, K.T. Bush, B.O. Palsson, and S.K. Nigam. (2013). Multispecific drug transporter slc22a8 (oat3) regulates multiple metabolic and signaling pathways. Drug Metab Dispos 41: 1825-1834. 23920220
Wu, X., R. Kekuda, W. Huang, Y.J. Fei, F.H. Leibach, J. Chen, S.J. Conway, and V. Ganapathy. (1998). Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. J. Biol. Chem. 273: 32776-32786. 9830022
Wuchiyama, J., M. Kimura, and I. Yamaguchi. (2000). A trichothecene efflux pump encoded by Tri102 in the biosynthesis gene cluster of Fusarium graminearum. J Antibiot (Tokyo) 53: 196-200. 10805582
Xie, X., H. Lin, X. Peng, C. Xu, Z. Sun, K. Jiang, A. Huang, X. Wu, N. Tang, A. Salvioli, P. Bonfante, and B. Zhao. (2016). Arbuscular Mycorrhizal Symbiosis Requires a Phosphate Transceptor in the Gigaspora margarita Fungal Symbiont. Mol Plant 9: 1583-1608. 27688206
Xu Y., Chen B., Chao H. and Zhou NY. (2013). mhpT encodes an active transporter involved in 3-(3-hydroxyphenyl)propionate catabolism by Escherichia coli K-12. Appl Environ Microbiol. 79(20):6362-8. 23934492
Xu, X., J. Chen, H. Xu, and D. Li. (2014). Role of a major facilitator superfamily transporter in adaptation capacity of Penicillium funiculosum under extreme acidic stress. Fungal Genet Biol 69: 75-83. 24959657
Yadav, V., M. Kumar, D.K. Deep, H. Kumar, R. Sharma, T. Tripathi, N. Tuteja, A.K. Saxena, and A.K. Johri. (2010). A phosphate transporter from the root endophytic fungus Piriformospora indica plays a role in phosphate transport to the host plant. J. Biol. Chem. 285: 26532-26544. 20479005
Yaffe, D., S. Radestock, Y. Shuster, L.R. Forrest, and S. Schuldiner. (2013). Identification of molecular hinge points mediating alternating access in the vesicular monoamine transporter VMAT2. Proc. Natl. Acad. Sci. USA 110: E1332-1341. 23530208
Yamada, K., Y. Saijo, H. Nakagami, and Y. Takano. (2016). Regulation of sugar transporter activity for antibacterial defense in Arabidopsis. Science 354: 1427-1430. 27884939
Yamada, S., N. Awano, K. Inubushi, E. Maeda, S. Nakamori, K. Nishino, A. Yamaguchi, and H. Takagi. (2006). Effect of drug transporter genes on cysteine export and overproduction in Escherichia coli. Appl. Environ. Microbiol. 72: 4735-4742. 16820466
Yamada, Y., K. Hideka, S. Shiota, T. Kuroda, and T. Tsuchiya. (2006). Gene cloning and characterization of SdrM, a chromosomally-encoded multidrug efflux pump, from Staphylococcus aureus. Biol Pharm Bull 29: 554-556. 16508166
Yamada, Y., S. Shiota, T. Mizushima, T. Kuroda, and T. Tsuchiya. (2006). Functional gene cloning and characterization of MdeA, a multidrug efflux pump from Staphylococcus aureus. Biol Pharm Bull 29: 801-804. 16595922
Yanagisawa, H., T. Miyashita, Y. Nakano, and D. Yamamoto. (2003). HSpin1, a transmembrane protein interacting with Bcl-2/Bcl-xL, induces a caspase-independent autophagic cell death. Cell Death Differ. 10: 798-807. 12815463
Yanatori, I., Y. Yasui, K. Miura, and F. Kishi. (2012). Mutations of FLVCR1 in posterior column ataxia and retinitis pigmentosa result in the loss of heme export activity. Blood Cells Mol Dis 49: 60-66. 22483575
Yang, C., D.A. Rodionov, X. Li, O.N. Laikova, M.S. Gelfand, O.P. Zagnitko, M.F. Romine, A.Y. Obraztsova, K.H. Nealson, and A.L. Osterman. (2006). Comparative genomics and experimental characterization of N-acetylglucosamine utilization pathway of Shewanella oneidensis. J. Biol. Chem. 281: 29872-29885. 16857666
Yang, J., X. Xu, and G. Liu. (2012). Amplification of an MFS Transporter Encoding Gene penT Significantly Stimulates Penicillin Production and Enhances the Sensitivity of Penicillium chrysogenum to Phenylacetic Acid. J Genet Genomics 39: 593-602. 23177147
Yao, J. and S.M. Bajjalieh. (2009). SVOP is a nucleotide binding protein. PLoS One 4: e5315. 19390693
Yasuda, S., S. Hasui, M. Kobayashi, S. Itagaki, T. Hirano, and K. Iseki. (2008). The mechanism of carrier-mediated transport of folates in BeWo cells: the involvement of heme carrier protein 1 in placental folate transport. Biosci. Biotechnol. Biochem. 72: 329-334. 18256483
Ye, L. and P.C. Maloney. (2002). Structure/function relationships in OxlT, the oxalate/formate antiporter of Oxalobacter formigenes: assignment of transmembrane helix 2 to the translocation pathway. J. Biol. Chem. 277: 20372-20378. 11919184
Ye, L., Z. Jia, T. Jung, and P.C. Maloney. (2001). Toplogy of OxlT, the oxalate transporter of Oxalobacter formigenes, determined by site-directed fluorescence labeling. J. Bacteriol. 183: 2490-2496. 11274108
Yin, Y., X. He, P. Szewczyk, T. Nguyen, and G. Chang. (2006). Structure of the multidrug transporter EmrD from Escherichia coli. Science 312: 741-744. 16675700
Yonezawa, A., S. Masuda, S. Yokoo, T. Katsura, and K. Inui. (2006). Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family). J Pharmacol Exp Ther 319: 879-886. 16914559
Yong, Z., Z. Kotur, and A.D. Glass. (2010). Characterization of an intact two-component high-affinity nitrate transporter from Arabidopsis roots. Plant J. 63: 739-748. 20561257
Yoshida, K.-I., Y. Yamamoto, K. Omae, M. Yamamoto, and Y. Fujita. (2002). Identification of two myo-inositol transporter genes of Bacillus subtilis. J. Bacteriol. 184: 983-991. 11807058
Young, C.S. and J.T. Beatty. (1998). A topological model of the Rhodobacter capsulatus light-harvesting I complex assembly protein LlaA (previously known as ORF1696). J. Bacteriol. 180: 4742-4745. 9721320
Yu, M., Y.W. Faan, W.Y. Chung, and J.S. Tsang. (2007). Isolation and characterization of a novel haloacid permease from Burkholderia cepacia MBA4. Appl. Environ. Microbiol. 73: 4874-4880. 17545323
Yu, S., A. Vit, S. Devenish, H.K. Mahanty, A. Itzen, R.S. Goody, and W. Blankenfeldt. (2011). Atomic resolution structure of EhpR: phenazine resistance in Enterobacter agglomerans Eh1087 follows principles of bleomycin/mitomycin C resistance in other bacteria. BMC Struct Biol 11: 33. 21849072
Zähner, D., X. Zhou, S.T. Chancey, J. Pohl, W.M. Shafer, and D.S. Stephens. (2010). Human antimicrobial peptide LL-37 induces MefE/Mel-mediated macrolide resistance in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 54: 3516-3519. 20498319
Zakataeva, N.P., E.A. Kutukova, S.V. Gronskiĭ, P.V. Troshin, V.A. Livshits, and V.V. Aleshin. (2006). [Export of metabolites by the proteins of the DMT and RhtB families and its possible role in intercellular communication]. Mikrobiologiia 75: 509-520. 17025177
Zakataeva, N.P., S.V. Gronskiy, A.S. Sheremet, E.A. Kutukova, A.E. Novikova, and V.A. Livshits. A new function for the Bacillus PbuE purine base efflux pump: efflux of purine nucleosides. Res. Microbiol. 158(8-9): 659-665. 17935948
Zhan, C., S. Wang, Y. Sun, X. Dai, X. Liu, L. Harvey, B. McNeil, Y. Yang, and Z. Bai. (2016). The Pichia pastoris transmembrane protein GT1 is a glycerol transporter and relieves the repression of glycerol on AOX1 expression. FEMS Yeast Res 16:. 27189360
Zhang Z., Wang R. and Xie J. (2015). Mycobacterium smegmatis MSMEG_3705 encodes a selective major facilitator superfamily efflux pump with multiple roles. Curr Microbiol. 70(6):801-9. 25697715
Zhang, C.C., M.C. Durand, R. Jeanjean, and F. Joset. (1989). Molecular and genetical analysis of the fructose-glucose transport system in the cyanobacterium Synechocystis PCC6803. Mol. Microbiol. 3: 1221-1229. 2507869
Zhang, X., K. Garbett, K. Veeraraghavalu, B. Wilburn, R. Gilmore, K. Mirnics, and S.S. Sisodia. (2012). A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2. J. Neurosci. 32: 8633-8648. 22723704
Zhang, Y., Q. Bao, L.A. Gagnon, A. Huletsky, A. Oliver, S. Jin, and T. Langaee. (2010). ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. Antimicrob. Agents Chemother. 54: 4772-4779. 20713660
Zhao R., Shin DS., Fiser A. and Goldman ID. (2012). Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1). Am J Physiol Cell Physiol. 303(6):C673-81. 22785121
Zhao R., Visentin M., Suadicani SO. and Goldman ID. (2013). Inhibition of the proton-coupled folate transporter (PCFT-SLC46A1) by bicarbonate and other anions. Mol Pharmacol. 84(1):95-103. 23609145
Zhao, R. and I.D. Goldman. (2007). The molecular identity and characterization of a proton-coupled folate transporter--PCFT; biological ramifications and impact on the activity of pemetrexed. Cancer Metastasis. Rev. 26: 129-139. 17340171
Zhao, R., E.S. Unal, D.S. Shin, and I.D. Goldman. (2010). Membrane topological analysis of the proton-coupled folate transporter (PCFT-SLC46A1) by the substituted cysteine accessibility method. Biochemistry 49: 2925-2931. 20225891
Zhao, R., M. Najmi, A. Fiser, and I.D. Goldman. (2016). Identification of an Extracellular Gate for the Proton-Coupled Folate Transporter (SLC46A1) by Cysteine Cross-Linking. J. Biol. Chem. [Epub: Ahead of Print] 26884338
Zhao, R., N. Diop-Bove, M. Visentin, and I.D. Goldman. (2011). Mechanisms of membrane transport of folates into cells and across epithelia. Annu. Rev. Nutr. 31: 177-201. 21568705
Zheng, H., G. Wisedchaisri, and T. Gonen. (2013). Crystal structure of a nitrate/nitrite exchanger. Nature 497: 647-651. 23665960
Zhou, J., E. Fernández, A. Galván, and A.J. Miller. (2000). A high affinity nitrate/nitrite transport system from Chlamydomonas requires two gene products. FEBS Lett. 466: 225-227. 10682832
Zorzano, A., M. Palacín, and A. Gumà. (2005). Mechanisms regulating GLUT4 glucose transporter expression and glucose transport in skeletal muscle. Acta Physiol Scand 183: 43-58. 15654919