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TCID	Name	Organismal Type	Example
2.A.1.1: The Sugar Porter (SP) Family
2.A.1.1.1	Galactose:H⁺ symporter	Bacteria	GalP of E. coli (P0AEP1)
2.A.1.1.2	Arabinose (xylose; galactose):H⁺ symporter	Bacteria	AraE of E. coli (P0AE24)
2.A.1.1.3	Xylose:H⁺ symporter	Bacteria	XylE of E. coli (P0AGF4)
2.A.1.1.4	Glucose uniporter	Bacteria	Glf of Zymomonas mobilis
2.A.1.1.5	Hexose uniporter	Yeast	HxtO of Saccharomyces cerevisiae
2.A.1.1.6	Galactose, glucose uniporter (also transports xylose)	Yeast	Gal2 of Saccharomyces cerevisiae
2.A.1.1.7	Quinate:H⁺ symporter	Fungi	Qay of Neurospora crassa
2.A.1.1.8	Myoinositol:H⁺ symporter	Yeast	ITR1 of Saccharomyces cerevisiae
2.A.1.1.9	Lactose, galactose:H⁺ symporter	Yeast	LacP of Kluyveromyces lactis
2.A.1.1.10	Maltose:H⁺ symporter	Yeast	MAL6 of Saccharomyces cerevisiae
2.A.1.1.11	General α-glucoside H⁺ symporter (Trehalose, maltose turanose, isomaltose, α-methyl-glucoside, maltotriose, palatinose, trehalose and melezitose): H⁺ symporter, Gtr3 or Agt1 (Smit et al., 2008).	Yeast	AGT1 of Saccharomyces cerevisiae
2.A.1.1.12	Glucose uniporter (also transports dehydro-ascorbate; Maulén et al., 2003). Down-regulated in the brains of Alzheimer's disease patients (Liu et al., 2008b).	Animals	Gtr3 (Glut3) of Rattus norvegicus (rat)
2.A.1.1.13	Fructose uniporter	Animals	Ftr of Homo sapiens
2.A.1.1.14	Hexose:H⁺ symporter	Plants	Hup1 of Chlorella kessleri
2.A.1.1.15	Putative sugar transporter	Archaea	Porter of Sulfolobus solfataricus
2.A.1.1.16	Low-affinity hexose (glucose, fructose, mannose, 2-deoxyglucose) uniporter	Protozoa	Gtr2 (D2) of Leishmania donovani
2.A.1.1.17	Glucose transporter	Protozoa	Th2A of Trypanosoma brucei
2.A.1.1.18	Glucose/mannose/fructose transporter and high affinity sensor, Snf3p (regulates glucose transport via other systems)	Yeast	Snf3p of Saccharomyces cerevisiae
2.A.1.1.19	Glucose transporter and low affinity sensor, Rgt2p (regulates glucose transport in conjunction with Snf3p)	Yeast	Rgt2p of Saccharomyces cerevisiae
2.A.1.1.20	Myoinositol:H⁺ symporter, MIT	Protozoa	MIT of Leishmania donovani; most similar to ITRI of Saccharomyces cerevisiae
2.A.1.1.21	Hexose:H⁺ symporter, Ght2 (Glucose > Fructose)	Yeast	Ght2 of Schizosaccharomyces pombe
2.A.1.1.22	Hexose:H⁺ symporter, Ght6 (Fructose > Glucose)	Yeast	Ght6 of Schizosaccharomyces pombe
2.A.1.1.23	Gluconate:H⁺ symporter, Ght3	Yeast	Ght3 of Schizosaccharomyces pombe
2.A.1.1.24	Hexose (Glucose and Fructose) transporter, PfHT1	Protozoa	PfHT1 of Plasmodium falciparum
2.A.1.1.25	Myoinositol:H⁺ symporter, HMIT (also transport other inositols including scyllo-, muco- and chiro-, but not allo-inositol) (Aouameur et al., 2007). Expressed in the golgi of the hippocampus and cortex. May also transport inositoltriphosphate (Di Daniel et al., 2009).	Animals	HMIT of Homo sapiens
2.A.1.1.26	Major myoinositol:H⁺ symporter, IolT	Bacteria	IolT (YdjK) of Bacillus subtilis
2.A.1.1.27	Minor myoinositol:H⁺ symporter, IolF	Bacteria	IolF of Bacillus subtilis
2.A.1.1.28	The erythrocyte/brain hexose facilitator, Gtr1 or Glut1. Also transports D-glucose, dehydroascorbate, and the flavonone, quercetin, via one channel and water via a distinct channel. Sugar transport has been suggested to function via a sliding mechanism involving several sugar binding sites (Cunningham et al., 2006). (Receptor for human T-cell leukemia virus (HTLV)) (Manel et al., 2003). Regulated by stomatin to take up dehydroascorbate (Montel-Hagen et al., 2008). Mutations cause Glut1 deficiency syndrome, a human encephalopathy that results from decreased glucose flux through the blood brain barrier (Pascual et al., 2008). Mueckler and Makepeace (2009) have presented a model of the exofacial substrate-binding site and helical folding of Glut1. Glut 1, 2, 4 and 9 are functional both in the plasma membrane and the endoplasmic reticulum (Takanaga and Frommer, 2010). Down-regulated in the brains of Alzheimer's disease patients (Liu et al., 2008b).	Animals	Gtr1 of Homo sapiens
2.A.1.1.29	Glucosamine/glucose uniporter, Glut-2 (may also transport dehydroascorbate (Maulén et al., 2003), and cotransport water against an osmotic gradient (Naftalin, 2008))	Animals	Glut2 of Homo sapiens (P11168)
2.A.1.1.30	Low affinity, constitutive, glucose (hexose; xylose) uniporter, Hxt4 (LGT1) (also transports arsenic trioxide [As(OH)₃] as do Hxtl, 3, 5, 7 and 9) (Liu et al., 2004)	Yeast	Hxt4 of Saccharomyces cerevisiae
2.A.1.1.31	High affinity, glucose-repressible, glucose (hexose) uniporter (Hxt6).	Yeast	Hxt6 of Saccharomyces cerevisiae
2.A.1.1.32	Glucose/fructose:H⁺ symporter, GlcP (Zhang et al., 1989)	Bacteria	GlcP of Synechocystis sp. (P15729)
2.A.1.1.33	Fructose:H⁺ symporter, Frt1 (Diezemann and Boles, 2003)	Yeast	Frt1 of Kluyveromyces lactis (CAC79614)
2.A.1.1.34	The broad specificity sugar/sugar alcohol (myo-inositol, glycerol, ribose, sorbitol, mannitol, xylitol, erythritol, etc) H⁺ symporter, AtPLT5 (transports a wide range of hexoses, pentoses, tetroses, sugar alcohols and a sugar acid, but not disaccharides) (Reinders et al., 2005) (expressed in roots, leaves and floral organs) (Klepek et al., 2004)	Plants	AtPLT5 of Arabidopsis thaliana (Q8VZ80)
2.A.1.1.35	The major glucose (or 2-deoxyglucose) uptake transporter, GlcP (van Wezel et al., 2005)	Bacteria	GlcP of Streptomyces coelicolor (Q7BEC4)
2.A.1.1.36	The low affinity, glucose-inducible glucose transporter, MstE (Forment et al., 2006)	Fungi	MstE of Aspergillus nidulans (Q400D8)
2.A.1.1.37	The glucose/fructose facilitator, Glut7 (SLC2A7) (a single mutation, I314V, results in loss of fructose transport but retention of glucose transport (Manolescu et al., 2005)	Animals	Glut7 of Homo sapiens (AAS 78590)
2.A.1.1.38	The glycerol:H⁺ symporter, Stl1p (Ferreira et al., 2005)	Yeast	Stl1p of Saccharomyces cerevisiae (NP_010825)
2.A.1.1.39	The high affinity glucose transporter, Hgt1 (Baruffini et al., 2006)	Yeast	Hgt1 of Kluyveromyces lactis (P49374)
2.A.1.1.40	The xylose facilitator, Xylhp (Nobre et al., 1999)	Yeast	Xylhp of Debaryomyces hansenii (AAR06925)
2.A.1.1.41	The D-xylose:H⁺ symporter, XylT (K_m=220 μM; inhibited competitively by 6-deoxyglucose (K_i=220 μM), but not by other sugars tested) (Chaillou et al., 1998)	Bacteria	XylT of Lactobacillus brevis (O52733)
2.A.1.1.42	The D-glucose:H⁺ symporter, GlcP (glucose uptake is inhibited by 2-deoxyglucose, mannose and galactose) (Parche et al., 2006)	Bacteria	GlcP of Bifidobacterium longum (AAN25419)
2.A.1.1.43	The monosaccharide (MST) (glucose > mannose > galactose > fructose):H⁺ symporter, MST1 (Schussler et al., 2006).	Fungi	MST1 of Geosiphon pyriformis (A0ZXK6)
2.A.1.1.44	The hexose (glucose and fructose but not galactose) transporter (Glut11; SLC2A11) (Scheepers et al., 2005)	Animals	Glut11 of Homo sapiens (Q9BYW1)
2.A.1.1.45	Vacuolar (tonoplast) glucose transporter1, Vgt1 (important for seed germination and flowering) (Aluri and Büttner, 2007)	Plants	Vgt1 of Arabidopsis thaliana (Q8L6Z8)
2.A.1.1.46	The blastocyst/testis glucose transporter, Glut8 (Doege et al., 2000) (insulin stimulated in blastocysts) (Carayannopoulos et al., 2000).	Animals	Glut8 of Mus musculus (Q9JIF3)
2.A.1.1.47	The embryonic glucose transporter, Glut9 (Carayannopoulos et al., 2004)	Animals	Glut9 of Mus musculus (Q5ERC7)
2.A.1.1.48	The pentose/hexose transporter (sugar transport protein 2), STP2. (Expressed during pollen maturation and early stages of gametophyte development) (Truernit et al., 1999)	Plants	STP2 of Arabidopsis thaliana (Q9LNV3)
2.A.1.1.49	The sink-specific, stress-regulated monosaccharide uptake porter, STP4. (Induced upon wounding or infection with bacteria or fungi; expressed in roots and flowers) (Truernit et al., 1996)	Plants	STP4 of Arabidopsis thaliana (Q39228)
2.A.1.1.50	The glucose/fructose:H⁺ symporter, STP13. Expressed in vascular tissues and induced during programmed cell death (Norholm et al., 2006)	Plants	STP13 of Arabidopsis thaliana (Q94AZ2)
2.A.1.1.51	Glucose/xylose: H⁺ symporter, Gsx1 (Leandro et al., 2006)	yeast	Gsx1 of Candida intermedia (Q2MEV7)
2.A.1.1.52	The glucose transport protein, GTP1 (Skelly et al., 1994)	Animals	GTP1 of Schistosoma mansoni (Q26579)
2.A.1.1.53	Myo-Inositol uptake porter, IolT1 (Km=0.2mM) (Krings et al., 2006).	Bacteria	IolT1 of Corynebacterium glutamicum (Q8NTX0)
2.A.1.1.54	Myo-Inositol (Km=0.45mM) uptake porter, IolT2 (Krings et al., 2006)	Bacteria	IolT2 of Corynebacterium glutamicum (Q8NL90)
2.A.1.1.55	L-arabinose:proton symporter, AraE (Sa-Nogueira and Ramos, 1997).	Bacteria	AraE of Bacillus subtilis (P96710)
2.A.1.1.56	High affinity monosaccharide (K_M ≈ 20 �M):H⁺ symporter, Stp6 (takes up glucose, 3-O-methylglucose, mannose, fructose, galactose and to a lesser extent, xylose and ribulose. (Scholz-Starke et al., 2003)	Plants	Stp6 of Arabidopsis thaliana (Q9SFG0)
2.A.1.1.57	High affinity (15 μM) glucose (monosaccharides including xylose):H⁺ symporter, MstA (Jørgensen et al., 2007).	Fungi	MstA of Aspergillus niger (Q8J0V1)
2.A.1.1.58	Low affinity glucose:H⁺ symporter, MstC (Jørgensen et al., 2007).	Fungi	MstC of Aspergillus niger (Q8J0U9)
2.A.1.1.59	The glucose transporter, GLUT10, was originally believed to be responsible for Type 2 diabetes. It is now believed to be responsible for arterial tortuosity, a rare autosomal recessive connective tissue disease (Callewaert et al., 2007). GLUT10 transports glucose and 2-deoxy glucose (K_m=0.3 mM), and is inhibited by galactose and phloretin (Coucke et al., 2006).	Animals	GLUT10 of Homo sapiens (O95528)
2.A.1.1.60	The major hexose transporter, Htr1 (mediates the active uptake of hexoses by sugar:H⁺ symport. Can transport glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose. Confers sensitivity to galactose in seedlings. K_m=20 uM for glucose) (Stadler et al., 2003; Boorer et al., 1994)	Plants	Htr1 of Arabidopsis thaliana (P23586)
2.A.1.1.61	High affinity monosaccharide (K_m = 25 �M) transporter (takes up glucose, galactose, mannose, xylose and 3-O-methylglucose, but not fructose and ribose), STP11 (expressed in pollen tubes) (Schneidereit et al., 2005)	Plants	STP11 of Arabidopsis thaliana (Q9FMX3)
2.A.1.1.62	High affinity (0.24mM) plasma membrane myoinositol-specific H⁺ symporter, INT4 (Schneider et al., 2006)	Plants	INT4 of Arabidopsis thaliana (O23492)
2.A.1.1.63	Low affinity inositol (myoinsoitol (Km = 1 mM), scylloinositol, d-chiroinositol and mucoinositol):H⁺ symporter (expressed in the anther tapetum, the vasculature, and the leaf mesophyll (Schneider et al., 2007)	Plants	INT2 of Arabidopsis thaliana (Q9C757)
2.A.1.1.64	The hexose sensor, Hxs1 (believed to be non-transporting) (Stasyk et al., 2008)	Yeast	Hxs1 of Hansenula polymorpha (B1PM37)
2.A.1.1.65	Glucose permease GlcP (Pimentel-Schmitt et al., 2008) (most similar to 2.A.1.1.32)	Bacteria	GlcP of Mycobacterium smegmatis (A0QZX3)
2.A.1.1.66	The tonoplast H⁺:Inositol symporter 1, Int1 (mediates efflux from the tonoplast to the cytoplasm (Schneider et al., 2008) (most similar to 2.A.1.1.63 and 2.A.1.1.62).	Plants	Int1 of Arabidopsis thaliana (Q8VZR6)
2.A.1.1.67	Glucose/xylose facilitator-1, GXF1 (functions by sugar uniport; low affinity (Leandro et al., 2008)	Yeast	GXF1 of Candida intermedia (Q2MDH1)
2.A.1.1.68	The Glucose Transporter/Sensor Rgt2	Yeast	Rgt2 Pichia stipitis�(A3M0N3)
2.A.1.1.69	Sugar & polyol transporter 1 (SPT1): broad specificity; takes up glucose (Schilling and Oesterhelt, 2007). Loss of the first 3 TMSs of the 12 TMSs does not prevent sugar uptake or sugar recognition but lowers substrate affinity & transport rate, and abolished H⁺ symport (Schilling and Oesterhelt, 2007).	Red algae	SPT1 of Galdieria sulphuraria (A1Z264)
2.A.1.1.70	The 9TMS (lacking TMSs 1-3) sugar and polyol transporter 2; broad specificity, but does not transport glucose (Schilling and Oesterhelt, 2007).	Red algae	SPT2 of Galdieria sulphuraria (A1Z265)
2.A.1.1.71	Hexose (glucose) transporter, GT4 (D2) (almost identical to 2.A.1.1.16)	Trypanosomatidae	Hexose transporter, GT4 of Leishmania mexicana (B1PLM1)
2.A.1.1.72	The kidney basolateral voltage-driven urate efflux transporter (URATv1) (orthologue of 2.A.1.1.47) (Anzai et al., 2008).	Animals	URATv1 of Homo sapiens (Q9NRM0)
2.A.1.1.73	Glycerol uptake permease (Glycerol:H⁺ symporter) Stl1. (Involved in salt stress relief) (Kayingo et al. 2009) (similar to Stl1 of S. cerevisiae (2.A.1.1.38))	Yeast	Stl1 of Candida albicans (Q5A8J5)
2.A.1.1.74	The putative L-rhamnose porter, RhaY	Firmicutes, Actinobacteria	RhaY of Listeria monocytogenes (Q926Q9)
2.A.1.2: The Drug:H⁺ Antiporter-1 (12 Spanner) (DHA1) Family
2.A.1.2.1	Pyridoxine, pyridoxal, pyridoxamine, amiloride:H⁺ cotransporter (Km (pyridoxine) = 22 μM) (Stolz et al., 2005). Also takes up thiamine (Vogl et al., 2008).	Yeast	Bsu1 (Car1) of Schizosaccharomyces pombe (P33532)
2.A.1.2.2	Cycloheximide:H⁺ antiporter	Yeast	CyhR of Candida maltosa
2.A.1.2.3	Chloramphenicol:H⁺ antiporter; multidrug exporter; isopropyl β-thiogalactoside exporter	Bacteria	CmlA of Pseudomonas aeruginosa
2.A.1.2.4	Tetracycline:H⁺ antiporter	Bacteria	TetA of E. coli
2.A.1.2.5	Multidrug (14- and 15-membered macrolides, lincosamides, streptogramins, tetracyclines, daunomycin, ethidium bromide, etc.):H⁺ antiporter, LmrP. Two proton translocation pathways have been proposed (Bapna et al., 2007), but Schaedler and van Veen, 2010 have provided evidence that a flexible cation binding site in LmrP is associated with variable proton coupling.	Gram-positive bacteria	LmrP of Lactococcus lactis
2.A.1.2.6	(Benomyl, cycloheximide, methotrexate, fluconazole, etc.):H⁺ antiporter (Basso et al., 2010).	Yeast	CaMDR1 of Candida albicans
2.A.1.2.7	(Bicyclomycin, sulfathiazole, tetracycline, fosfomycin, acriflavin, etc.):H⁺ antiporter	Gram-negative bacteria	Bcr of E. coli
2.A.1.2.8	(Spermidine; fluoroquinolones, acriflavin, chloramphenicol, ethidium bromide, etc.):H⁺ antiporter	Gram-positive bacteria	Blt of Bacillus subtilis
2.A.1.2.9	(Hydrophobic uncoupler e.g., CCCP, benzalkonium, SDS):H⁺ antiporter	Gram-negative bacteria	EmrD of E. coli
2.A.1.2.10	Quinolone (and other drug):H⁺ antiporter	Bacteria	NorA of Staphylococcus aureus (P0A0J7)
2.A.1.2.11	Monoamine transporter; drug (doxorubicin, ethidium bromide-6-G):H⁺ antiporter	Animals	VMAT1 of Rattus norvegicus
2.A.1.2.12	Chromaffin granule monoamine (and drug) transporter, VAT1	Animals	VAT1 of Homo sapiens
2.A.1.2.13	Acetylcholine:H⁺ antiporter	Animals	Unc17 of Caenorhabditis elegans
2.A.1.2.14	Putative arabinose efflux porter	Bacteria	AraJ of E. coli
2.A.1.2.15	Arabinose (and isopropyl β-D-thio- galactopyranoside):H⁺ antiporter, YdeA	Bacteria	YdeA of E. coli
2.A.1.2.16	Polyamines (spermine, spermidine, putrescene); paraquat; methylgloxal bis(guanylhydrazone):H⁺ antiporter (in the plasma membrane) (activated by phosphorylation) (Uemura et al., 2005)	Yeast	TPO1 (YLL028w) of Saccharomyces cerevisiae
2.A.1.2.17	Fluconazole:H⁺ antiporter	Yeast	Flr1 of Saccharomyces cerevisiae
2.A.1.2.18	Lactose and melibiose (>>IPTG) efflux pump, SotB	Bacteria	SotB of Erwinia chrysanthemi
2.A.1.2.19	The multidrug (chloramphenicol, tetra- cycline, norfloxacin, doxorubicin, trimethoprim, acriflavin, ethidium bromide, tetraphenylphosphonium, TPP, benzalkonium, ciprofloxacin, thiamphenicol, IPTG) resistance exporter, MdfA (catalyzes both electrogenic and electroneutral transport) (Adler and Bibi, 2004). Can function as a Na⁺ (K⁺)/H⁺ antiporter (Lewinson and Bibi 2001; Higgins, 2007). For review of MdfA see Lewinson et al., 2006. The conformational switch accompanying transport is induced by promiscuous binding of substrates and/or inhibitors to the binding pocket (Fluman et al., 2009).	Bacteria	MdfA of E. coli (P0AEY8)
2.A.1.2.20	The fosfomycin resistance protein, YceE	Bacteria	YceE of E. coli
2.A.1.2.21	The norfloxacin/enoxacin resistance protein, YceL	Bacteria	YceL of E. coli (P69367)
2.A.1.2.22	The chloramphenicol resistance protein, YidY	Bacteria	YidY of E. coli
2.A.1.2.23	The fructose-specific facilitator (uniporter), Ffz1 (Pina et al., 2004)	Yeast	Ffz1 of Zygosaccharomyces bailii (CAD56485)
2.A.1.2.24	The multidrug resistance efflux pump, CgMDR (exports fluoroquinolones and chloramphenicol) (Vardy et al., 2005)	Bacteria	CgMDR of Corynebacterium glutamicum (NP_600365)
2.A.1.2.25	The purine base/nucleoside (nucleosides: inosine, adenosine and guanosine; bases: hypoxanthine adenine, guanine 2-fluoroadenine) efflux pump, YdhL (PbuE) (Johansen et al., 2003; Nygaard and Saxild, 2005; Zakataeva et al., 2007).	Bacteria	PbuE of Bacillus subtilis (O05504)
2.A.1.2.26	The purine ribonucleoside (inosine, adenosine, guanosine, 6-mercaptopurine ribonucleoside) efflux pump (H⁺ antiporter), NepI (YicM) (Gronskiy et al., 2005)	Bacteria	NepI of E. coli (P0ADL1)
2.A.1.2.27	The alcaligin siderophore exporter, AlcS (Brickman and Armstrong, 2005)	Bacteria	AlcS of Bordetella pertussis (CAE42734)
2.A.1.2.28	The vesicular acetylcholine transporter, VAChT (pumps acetylcholine into synaptic vesicles)	Animals	VAChT of Homo sapiens (Q16572)
2.A.1.2.29	The vesicular monoamine transporter, VMAT2 (pumps dopamine, norepinephrine, serotonin and histamine into synaptic vesicles)	Animals	VMAT2 of Homo sapiens (Q05940)
2.A.1.2.30	The hippocampus abundant transcript-like 1 protein, HIATL1 (putative drux exporter)	Animals	HIATL1 of Homo sapiens (NP_115947)
2.A.1.2.31	The multidrug transporter, QDR2, required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptake	Bacteria	QDR2 of Saccharomyces cerevisiae (P40474)
2.A.1.2.32	The chloramphenicol resistance protein, Chl^R	Bacteria	Chl^R of Streptomyces lividans (P31141)
2.A.1.2.33	The Hol1 MFS transporter (Mutation allows the uptake of histidinol and other cations (Wright et al., 1996). The N-terminal 200 residues show 22% identity with 2.A.1.2.1 and 2.A.1.2.16).	Yeast	Hol1 of Saccharomyces cerevisiae (P53389)
2.A.1.2.34	The MDR efflux pump, PmrA (exports fluoroquinolone and other compounds) and other components including the antimicrobial peptide, colistin (Pamp et al., 2008).	Bacteria	PmrA of Streptococcus pneumoniae (P0A4K4)
2.A.1.2.35	The caffeine resistance protein 5 (Caf5) (Benko et al., 2004)	Bacteria	Caf5 of Schizosaccharomyces pombe (O94528)
2.A.1.2.36	The multidrug resistance protein Aqr1 (YNL065w) (exports short chain monocarboxylates but not more hydrophobic acids such as octonate and quinidine. Also exports ketoconazole and crystal violet (Tenreiro et al., 2002)).	Yeast	Aqr1 of Saccharomyces cerevisiae (P53943)
2.A.1.2.37	The legiobactin (siderophore) exporter (most similar to 2.A.1.2.9; 23% identity) (Allard et al., 2006)	Gram-negative bacterium	IbtB of Legionella pneumophila LbtA (Q45RG2) LbtB (Q5WX21)
2.A.1.2.38	Tetracycline-specific exporter, TetA39 (most like 2.A.1.2.4) (Thompson et al., 2007).	Bacteria	TetA39 of Acinetobacter spp. (Q56RY7)
2.A.1.2.39	Tetracycline-specific exporter, TetA41 (most like 2.A.1.2.4) (Thompson et al., 2007).	Bacteria	TetA41 of Serratia marcescens (Q5JAK9)
2.A.1.2.40	The dityrosine exporter, Dtr1 (required for formation of the outer layer of the cell wall (Morishita and Engebrecht, 2008)).	Yeast	Dtr1 of Saccharomyces cerevisiae (P38125)
2.A.1.2.41	The tetracycline resistance determinant, TetA42 from a deep terrestrial subsurface bacterium (Brown et al., 2008).	Bacteria	TetA42 of Micrococcus sp. SMCC G8878 (B2YGG2)
2.A.1.2.42	The multidrug efflux pump, EmrD-3 (exports ethidium, linezolid, tetraphenylphosphonium chloride, rifampin, erythromycin, minocycline, trimethoprim, chloramphenicol, and rhodamine) (Smith et al., 2009).	Bacteria	EmrD-3 of Vibrio cholerae (Q9KMQ3)
2.A.1.2.43	The multidrug efflux pump, Qdr3 (exports polyamines, quinidine, barban, cisplatin and bleomycin). The two halves of the protein each have an N-terminal. 150 residue hydrophilic region found in many fungi followed by a 200 residue, 6 TMS, transmembrane region. This suggests that an intragenic duplication event gave rise to 12 TMS proteins independently of most other MFS carriers, but this has not been demonstrated, possibly because of extensive sequence divergence of the second half.	Fungi	Qdr3 of Saccharomyces cerevisiae (P38227)
2.A.1.2.44	Diglucosyl-diacylglycerol exporter in flippase, LtaA (lipoteichoic acid protein A) (Gründling and Schneewind, 2007)	Firmicutes	LtaA of Staphylococcus aureus (Q2FZP8)
2.A.1.3: The Drug:H⁺ Antiporter-2 (14 Spanner) (DHA2) Family
2.A.1.3.1	The main boron exporter in yeast, Atr1 (Kaya et al. 2009) (Aminotriazole, 4-nitroquinoline-N-oxide, etc.):H⁺ antiporter	Yeast	Atr1 of Saccharomyces cerevisiae
2.A.1.3.2	(CCCP, nalidixic acid, rhodamine 6G, methylviologen, deoxycholate, growth inhibitory steroid hormones (estradiol and progesterone) (Elkins and Mullis, 2006) SDS, organomercurials, etc.):H⁺ antiporter	Gram-negative bacteria	EmrB of E. coli (P0AEJ0)
2.A.1.3.3	(Acriflavin, ethidium bromide, fluoroquinolones, etc.):H⁺ antiporter	Gram-positive bacteria	LfrA of Mycobacterium smegmatis
2.A.1.3.4	(Mono- and divalent organocation):H⁺ antiporter. Transmembrane helix 12 of QacA lines the bivalent cationic drug binding pocket (Hassan et al., 2007).	Gram-positive bacteria	QacA of Staphylococcus aureus (P0A0J9)
2.A.1.3.5	(Pristinamycin I and II, rifamycin, etc.):H⁺ antiporter	Gram-positive bacteria	Ptr of Streptomyces pristinaespiralis
2.A.1.3.6	Me²⁺�tetracycline:2H⁺ or 2K⁺ antiporter (the optimal Me²⁺ = Co²⁺) (Also transports Na⁺ or K⁺out in exchange for 2H⁺.)	Bacteria	TetK of Staphylococcus aureus (P02983)
2.A.1.3.7	Actinorhodin:H⁺ antiporter, ActVa or ActA (Tahlan et al., 2007)	Gram-positive bacteria	ActVa of Streptomyces coelicolor
2.A.1.3.8	Cephamycin:H⁺ antiporter	Gram-positive bacteria	CmcT of Nocardia lactamdurans
2.A.1.3.9	Lincomycin:H⁺ antiporter	Gram-positive bacteria	LmrA of Streptomyces lincolnensis
2.A.1.3.10	Methylenomycin:H⁺ antiporter	Gram-positive bacteria	MmrB of Bacillus subtilis
2.A.1.3.11	Puromycin:H⁺ antiporter	Gram-positive bacteria	Pur8 of Streptomyces lipmanii
2.A.1.3.12	Tetracenomycin:H⁺ antiporter	Gram-positive bacteria	TcmA of Streptomyces glaucescens
2.A.1.3.13	Unconjugated bile acid uptake transporter	Bacteria	BaiG of Eubacterium sp. strain VPI 12708
2.A.1.3.14	Methylviologen (paraquat):H⁺ antiporter (also exports ethidium bromide, acriflavin, malachite green, pyonine B and benzyl viologen)	Bacteria	SmvA of Salmonella typhimurium
2.A.1.3.15	Rifamycin:H⁺ antiporter	Bacteria	RifP of Amycolatopsis mediterranei
2.A.1.3.16	The Me²⁺�tetracycline:2H⁺ antiporter (Me²⁺ = Co²⁺, Mg²⁺, Mn²⁺)(also probably a Na⁺ or K⁺:2H⁺ antiporter)	Bacteria	TetA(L) of Bacillus subtilis
2.A.1.3.17	The trimethoprim-sensitivity protein, YebQ (increases sensitivity to trimethoprim)	Bacteria	YebQ of E. coli
2.A.1.3.18	Efflux pump for plant-bacterial signaling molecules, phytoalexins, flavenoids and salicylate as well as drugs, RmrB	Bacteria	RmrB of Rhizobium etli
2.A.1.3.19	Paraquot efflux pump, PqrB (Cho et al., 2003)	Bacteria	PqrB of Streptomyces coelicolor (AAG45950)
2.A.1.3.20	Long chain fatty acid efflux pump, FarB (Lee et al., 2003) (exports antimicrobial long chain fatty acids; functions with MFP auxillary protein, FarA (TC# 8.A.1.1.2)) (Lee et al., 2006)	Bacteria	FarB of Neisseria gonorrhoeae (AAD54074)
2.A.1.3.21	Siderophore, achromobactin efflux pump, YhcA (Franza et al., 2005)	Bacteria	YhcA of Erwinia (Pectobacterium) chrysanthemi (AAL14569)
2.A.1.3.22	The Tet38 tetracycline-resistance protein of Staphylococcus aureus (Truong-Bolduc et al., 2005)	Bacteria	Tet38 of Staphylococcus aureus (AAV80464)
2.A.1.3.23	The NorB multidrug resistance pump (exports hydrophilic quinolones, ethidium bromide, cetrimide, sparfloxacin, moxifloxacin and tetracycline) (Truong-Bolduc et al., 2005)	Bacteria	NorB of Staphylococcus aureus (BAB42529)
2.A.1.3.24	The VceAB multidrug (hydrophobic compounds including deoxycholate (DOC), antibiotics, such as chloramphenicol and nalidixic acid, and the proton motive force uncoupler, cyanide carbonyl m-chlorophenylhydrazone (CCCP)) resistance pump (functions with outer membrane VceC (TC#1.B.17.3.6) or OprM (2.A.6.2.21), an OMF family member; The C-terminal domain of the Pseudomonas aeruginosa OprM and the alpha-helical hairpin domain of Vibrio cholerae VceA play important roles in recognition/specificity/recruitment in the assembly of a functional, VceAB-OprM chimeric efflux pump (Bai et al., 2010).	Bacteria	VceAB of Vibrio cholerae VceB (MFS), NP_231054 VceA (MFP), NP_231053
2.A.1.3.25	The multidrug resistance efflux pump, HsMDR (YfmO2) (Vardy et al., 2005)	Archaea	HsMDR of Halobacterium sp. NRC-1 (NP_279495)
2.A.1.3.26	Novobiocin/deoxycholate exporting MDR efflux pump, YegB (Baranova and Nikaido, 2002)	Bacteria	YegB of E. coli (P36554)
2.A.1.3.27	The vacuolar basic amino acid (Arg, Lys, His) transporter, Vba3 (Shimazu et al., 2005)	Yeast	Vba3 of Saccharomyces cerevisiae (P25594)
2.A.1.3.28	MDR multidrug efflux pump, EbrE (involved in colony growth, dependent on Ca²⁺, Mg²⁺, Na⁺ and K⁺) (Lee et al., 2007)	Bacteria	EbrE of Streptomyces lividans (Q939A4)
2.A.1.3.29	The metal:tetracycline/oxytetracycline resistance efflux pump, TctB (563 aas)	Bacteria	TctB of Streptomyces rimosus (O69070)
2.A.1.3.30	Lincomycin resistance protein; Lincomycin:H⁺ antiporter, LmrB	Bacteria	LmrB of Bacillus subtilis (O35018)
2.A.1.3.33	The hydrophilic fluroquinolones efflux pump, QepA (Perichon et al., 2008). Exports hyrdophilic quinolones, norfloxacin, and ciprofloxacin.	Bacteria	QepA of E. coli (A5H8A5)
2.A.1.3.34	Landomycin A efflux pump, LanJ (Otash et al., 2008)	Bacteria	LanJ of Streptomyces cyanogenus (Q9ZGB6)
2.A.1.3.35	Multidrug (including novobiocin, streptomycin, and actinomycin D) resistance porter, MdtP (YusP)	Bacteria	MdtP of Bacillus subtilis (O32182)
2.A.1.3.36	The P55 drug efflux pump (Rv141Oc) (extrudes drugs including rifampicin and clifazimine, first- and second-line anti-tuberculosis drugs. CCCP and valinomycin inhibited drug resistance) (Ramón-García et al., 2009).	Bacteria	P55 drug efflux pump of Mycobacterium tuberculosis (P71678)
2.A.1.3.37	The 14 TMS FmtC (MrpF) protein, involved in methecillin resistance	Bacteria	FmtC of Staphylococcus aureus (D1QCY9)
2.A.1.4: The Organophosphate:P_i Antiporter (OPA) Family
2.A.1.4.1	Sugar-P:P_i antiporter (transports many sugar-phosphates - both 1- and 6-P esters)	Bacteria	UhpT of E. coli (P0AGC0)
2.A.1.4.2	P-glycerate:P_i antiporter	Bacteria	PgtP of Salmonella typhimurium
2.A.1.4.3	Glycerol-P:P_i antiporter (may function by a 'rocker switch' mechanism; Law et al., 2007).	Bacteria	GlpT of E. coli
2.A.1.4.4	Hexose-P:P_i antiporter regulatory protein; senses external glucose-6-P and transports it with high affinity and low efficiency	Bacteria	UhpC of E. coli
2.A.1.4.5	Microsomal glucose-6-P:Pi antiporter (glycogen storage disease (GSD1b and 1c); Gierke's disease protein) (SLC37A2; in mice, associated with white adipose tissue obesity and expressed at high levels in macrophage) (4 isoforms present in humans; Chen et al., 2008)	Animals	GSD1b of Homo sapiens
2.A.1.4.6	Glucose-6-P:P_i antiporter, Hpt (may also transport other organophosphates including C₃ organophosphates).	Bacteria	Hpt of Chlamydia pneumoniae (spQ9Z7N9 & gi9979188) & pirA72050
2.A.1.4.7	Putative glycerol-3-phosphate (G-3-P) transporter, G3PP (most similar to TC# 2.A.1.4.6, 22% identity)	Animals	G3PP of Homo sapiens (P57057)
2.A.1.5: The Oligosaccharide:H⁺ Symporter (OHS) Family
2.A.1.5.1	Lactose:H⁺ symporter, LacY. Transports lactose, melibiose and TMG.	Bacteria	LacY of E. coli
2.A.1.5.2	Raffinose:H⁺ symporter, RafB, can be mutated to transport maltose (Van Camp et al., 2007).	Bacteria	RafB of E. coli
2.A.1.5.3	Sucrose:H⁺ symporter, CscB, also transports maltose (Peng et al. 2009).	Bacteria	CscB of E. coli
2.A.1.5.4	Melibiose:H⁺ symporter, MelY (Shinnick et al., 2003). Transports melibiose and lactose, but not TMG (Tavoulari and Frillingos, 2007)	Bacteria	MelY of Enterobacter cloacae
2.A.1.6: The Metabolite:H⁺ Symporter (MHS) Family
2.A.1.6.1	Citrate:H⁺ symporter	Bacteria	CitA of Klebsiella pneumoniae
2.A.1.6.2	α-Ketoglutarate:H⁺ symporter	Bacteria	KgtP of E. coli (P0AEX3)
2.A.1.6.3	Dicarboxylate:H⁺ symporter	Bacteria	PcaT of Pseudomonas putida
2.A.1.6.4	(Poline/glycine-betaine):(H⁺/Na⁺) symporter (also transports taurine, ectoine, pipecolate, proline-betaine, N,N-dimethylglycine, carnitine, and 1-carboxymethyl-pyridinium) (subject to osmotic activation)	Bacteria	ProP of E. coli (P0C0L7)
2.A.1.6.5	4-Methyl-o-phthalate:H⁺ symporter	Bacteria	MopB of Burkholderia cepacia
2.A.1.6.6	Shikimate:H⁺ symporter	Bacteria	ShiA of E. coli
2.A.1.6.7	The citrate/tricarballylate:H⁺ symporter (CitA or TcuC); probably orthologous to 2.A.1.6.1 (Lewis et al., 2004)	Bacteria	TcuC of Salmonella enterica serovar Typhimurium LT2 (P0A2G3)
2.A.1.6.8	The acetate/monochloroacetate permease, Deh4p (Km = 5.5 mμM for acetate; 9 mμM for monochloroacetate) (Yu et al., 2007).	bacteria	Deh4 of Burkholderia cepacia (Q7X4L6)
2.A.1.7: The Fucose: H⁺ Symporter (FHS) Family
2.A.1.7.1	L-Fucose:H⁺ symporter	Bacteria	FucP of E. coli
2.A.1.7.2	Glucose/galactose porter	Bacteria	Ggp of Brucella abortus (P0C105)
2.A.1.7.3	Glucose/mannose:H⁺ symporter (Paulsen et al., 1998)	Bacteria	GlcP of Bacillus subtilis
2.A.1.7.4	Rat kidney Na⁺-dependent glucose (methyl α-glucoside) transporter, NaGLT1 (glucose:Na⁺:Na⁺=1:1) (Horiba et al., 2003)	Animals	NaGLT1 of Rattus norvegicus (BAC57446)
2.A.1.7.5	2-Deoxy-D-ribose porter, DeoP (Christensen et al., 2003)	Bacteria	DeoP of Salmonella typhimurium LT-2 (gi 16767076)
2.A.1.7.6	The putative sucrose permease, ScrT	Bacteria	ScrT of Shewanella frigidimarina (ABI73814)
2.A.1.7.7	The Na⁺-dependent sugar transporter, HP1174 (transports glucose, galactose, mannose and 2-deoxyglucose (Psakis et al. 2009)). (most similar to 2.A.1.7.2; 49% identity)	Bacteria	HP1174 of Helicobacter pylori (O25788)
2.A.1.7.8	The putative N-acetylglucosamine porter, NagP (Yang et al., 2006).	Proteobacteria	NagP of Shewanella oneidensis (Q8EBL0)
2.A.1.7.9	The putative N-acetylgalactosamine porter, AgaP (Yang et al., 2006).	Proteobacteria	AgaP of Shewanella amazonensis (A1S4V0)
2.A.1.7.10	The putative glucose porter, GlcP	Proteobacteria	GlcP of Shewanella amazonensis (A1S5F4)
2.A.1.7.11	The putative mannose porter, ManP^l	Proteobacteria	ManP^l of Shewanella amazonensis (A1S297)
2.A.1.7.12	The putative trehalose porter, TreT	Proteobacteria	TreT of Shewanella frigidimarina (Q07XD1)
2.A.1.8: The Nitrate/Nitrite Porter (NNP) family
2.A.1.8.1	Nitrate/H⁺ symporter (K1) Nitrate/nitrite antiporter (K2)	Bacteria	NarK (NarK1-K2) of E. coli
2.A.1.8.2	Nitrate uptake porter	Bacteria	NasA of Bacillus subtilis
2.A.1.8.3	Nitrate/nitrite uptake porter	Bacteria	NrtP of Synechococcus PCC7002
2.A.1.8.4	Nitrate transporter	Diatoms	Nitrate porter of Cylindrotheca fusiformis
2.A.1.8.5	Nitrate transporter	Fungi	CrnA of Emericella nidulans
2.A.1.8.6	Nitrate transporter	Algae	Nitrate porter of Chlamydomonas reinhardtii
2.A.1.8.7	Nitrate/nitrite high affinity, two component uptake transporter Nrt23/Nar2	Algae	Nrt23/Nar2 of Chlamydomonas reinhardtii; Nrt23; Nar2 (Cre)
2.A.1.8.8	NO₂^- extrusion, NO₃^-/NO₂^- exchange permease, NarK1	Bacteria	NarK1 of Thermus thermophilus HB8
2.A.1.8.9	NO₂^- extrusion, NO₃^-/NO₂^- exchange permease, NarK2	Bacteria	NarK2 of Thermus thermophilus HB8
2.A.1.8.10	NO₃^-/NO₂^- transporter (NO₃^- uptake permease; NO₂^- exporter) (NO₃^-/NO₂^- antiporter ?) (stress-induced; Clegg et al., 2006)	Bacteria	NarU of E. coli
2.A.1.8.11	The 24 TMS, 2 domain, NarK1-NarK2 porter (NarK1 = a NO₃^-/H⁺ symporter; NarK2 = a NO₃^-/NO₂^- antiporter). NarK1 is a nitrate/proton symporter with high affinity for nitrate while NarK2 is a nitrate/nitrite antiporter with lower affinity for nitrate (Goddard et al., 2008). Each transporter requires two conserved arginine residues for activity. A transporter consisting of inactivated NarK1 fused to active NarK2 has a dramatically increased affinity for nitrate compared with NarK2 alone, implying a functional interaction between the two domains (Goddard et al., 2008).	Bacteria	NarK1/NarK2 of Roseobacter denitrificans (Q166T6)
2.A.1.8.12	The root cortical and epidermal cell, high affinity, plasma membrane, NO₃^- uptake transporter, NRT2.1 (Wirth et al., 2007). Also functions in nitrate sensing and signaling (Miller et al., 2007; Girin et al., 2010).	Plants	NRT2.1 of Arabidopsis thaliana (O82811)
2.A.1.9: The Phosphate: H⁺ Symporter (PHS) Family
2.A.1.9.1	High affinity P_i uptake porter (also functions in Mn²⁺ homeostasis); may transport a phosphate · Mn complex (Jensen et al., 2003)	Yeast	Ph84 of Saccharomyces cerevisiae
2.A.1.9.2	P_i uptake porter	Fungi	Pho-5 of Neurospora crassa
2.A.1.9.3	P_i uptake porter. Four close paralogues in Medicago truncatula (PT1-4), all localized to roots, show differing affinities for phosphate (Liu et al. 2008).	Plants	PT1 of Solanum tuberosum
2.A.1.9.4	Pht1;2(1;4) (PT2), a low affinity Pi uptake transporter, functioning throughout the plant (Ai et al., 2009) (76% identical to 2.A.1.9.3).	Plants	Pht1;2(1;4) of Oryza sativa (Q01MW8)
2.A.1.9.5	Pht1;6 (PT6), a high affinity Pi uptake transporter, functioning thoughout the plant (Ai et al., 2009) (75% identical to 2.A.1.9.3)	Plants	Pht1;6 (PT6) of Oryza sativa (Q8H6H0)
2.A.1.10: The Nucleoside: H⁺ Symporter (NHS) Family
2.A.1.10.1	Nucleoside porter (Guanosine, inosine, cytidine and thymidine but not uridine, adenosine and xanthosine are transported.)	Bacteria	NupG of E. coli (P0AFF4)
2.A.1.10.2	Xanthosine porter (Xanthosine, inosine, adenosine, cytidine and thymidine but not guanosine and uridine are transported.)	Bacteria	XapB of E. coli
2.A.1.11: The Oxalate:Formate Antiporter (OFA) Family
2.A.1.11.1	The oxalate:formate antiporter	Bacteria	OxlT of Oxalobacter formigenes
2.A.1.12: The Sialate:H⁺ Symporter (SHS) Family
2.A.1.12.1	The sialic acid porter	Bacteria	NanT of E. coli
2.A.1.12.2	The lactate/pyruvate:H⁺ symporter	Yeast	Jen1 (YKL217w) of Saccharomyces cerevisiae
2.A.1.13: The Monocarboxylate Porter (MCP) Family
2.A.1.13.1	The proton-linked monocarboxylate (lactate, pyruvate, mevalonate, branched chain oxo acids, β-hydroxybutyrate, γ-hydroxybutyrate, butyrate, acetoacetate and acetate) uptake/efflux porter. Activity is stimulated by direct interaction with carbonic anhydrase isoform II (Becker et al., 2005). [This transporter interacts physically with the chaperone protein Basigin (CD147; TC #8.A.23.1.1) which is required both for targetting to the plasma membrane and for activity. Mct-2 uses a different chaperone protein, GP70. Mct-1 also transports the methionine hydroxy analogue 2-hydroxy (4-methylthio) butanate (Martin-Venegas et al., 2007). Activity is stimulated by binding of carbonic anhydrase II (Becker and Deitmer, 2008)	Animals, yeast, fungi, protozoa	Mct-1 of Homo sapiens
2.A.1.13.2	The low affinity aromatic amino acid (Tyr, Trp, Phe) transporter, TAT1 (also transports N-methyl amino acids)	Animals	Tat1 of Rattus norvegicus
2.A.1.13.3	The thyroid hormone transporter, MCT8 (transports L- and D-isomers of thyroxine (T4), 3,3',5-triiodothyronine (T3), 3,3'5'-triiodothyronine (rT3) and 3,3'-diiodothyronine [Km values = 2-5 μM; Leu, Phe, Trp and Tyr were not transported]) (Friesema et al., 2003). Loss of function mutations in MCT8 lead to severe X-linked psychomotor retardation and elevated serum T3 levels (Jansen et al., 2008).	Animals	MCT8 of Mus musculus (O70324)
2.A.1.13.4	The high affinity (17 μM) facilitated diffusion, riboflavin-regulated riboflavin uptake system, Mch5 (Reihl and Stolz, 2005)	Yeast	Mch5 of Saccharomyces cerevisiae (NP_014951)
2.A.1.13.5	Monocarboxylate transporter-2 (MCT2). Transports γ-hydroxybutyrate (Wang and Morris, 2007)	Metazoa	MCT2 of Homo sapiens (O60669)
2.A.1.13.6	Plasma membrane lactate/pyruvate transporter, SLC16A3. MCT members have different substrate/inhibitor specificities and transport kinetics.	Animals	SLC16A3 (603877) of Homo sapiens (O15427)
2.A.1.13.7	Monocarboxylate transporter-4 (MCT4). Lactate transport via the monocarboxylate transporter isoform 4 is non enzymatically stimulated by carbonic anhydrase II (Becker et al., 2010).	Animals	MCT4 of Homo sapiens (O15374)
2.A.1.14: The Anion:Cation Symporter (ACS) Family
2.A.1.14.1	Glucarate porter	Bacteria	GudT of Bacillus subtilis
2.A.1.14.2	Hexuronate (glucuronate; galacturonate) porter	Bacteria	ExuT of E. coli (P0AA78)
2.A.1.14.3	Putative tartrate porter	Bacteria	TtuB of Agrobacterium vitis
2.A.1.14.4	Dipeptide (e.g., Gly-Leu), allantoate, ureidosuccinate, allantoin porter (Cai et al., 2007).	Yeast	Dal5 of Saccharomyces cerevisiae
2.A.1.14.5	Phthalate porter	Bacteria	Pht1 of Pseudomonas putida
2.A.1.14.6	Na:P_i symporter	Animals	Npt1 of Mus musculus
2.A.1.14.7	Galactonate transporter	Bacteria	DgoT (YidT) of E. coli (P0AA76)
2.A.1.14.8	Phthalate porter	Bacteria	OphD of Burkholderia cepacia
2.A.1.14.9	Putative p-hydroxyphenylacetate porter	Bacteria	HpaX of Salmonella dublin
2.A.1.14.10	Lysosomal sialate transporter (sialate storage disease protein)	Animals	Sialin of Homo sapiens
2.A.1.14.11	Plasma membrane, high affinity nicotinate permease, Tna1	Yeast	Tna1 of Saccharomyces cerevisiae
2.A.1.14.12	Plasma membrane, high affinity biotin:H⁺ symporter, Vht1	Yeast	Vht1 of Saccharomyces cerevisiae
2.A.1.14.13	Broad specificity brain synaptic vesicle anion:Na⁺ symporter (transports glutamate, phosphate, chloride, etc.)(BNPI, EAT-4, VGLUT1)	Animals	BNPI of Rattus norvegicus
2.A.1.14.14	Probable D-galactarate:H⁺ symporter, YhaU	Bacteria	YhaU of E. coli
2.A.1.14.15	Apical membrane renal proximal tubule. Voltage-driven but Na⁺-independent organic anion transporter, OAT_v1 (transports p-aminohippurate; probably transports organic anions but not cations and not inorganic phosphate. It may catalyze excretion of various drugs, xenobiotics, and their metabolites) (Jutabha et al., 2003)	Animals	OAT_v1 of Sus scrofa (Q7YQJ7)
2.A.1.14.16	The broad specificity brain synaptic vesicle anion transporter (transports glutamate in a Δψ-dependent fashion requiring Cl^- but phosphate by a Na⁺-dependent mechanism via a different pathway/mechanism (Juge et al., 2006).	Animals	VGLUT2 of Rattus norvegicus (Q9JI12)
2.A.1.14.17	Pantothenate:H⁺ symporter, Liz1 (mutants cause abnormal mitosis due to a defect in ribonucleotide reductase) (Stolz et al., 2004)	Yeast	Liz1 of Schizosaccharomyces pombe (O43000)
2.A.1.14.18	Pantothenate:H⁺ symporter, Fen2	Yeast	Fen2 of Saccharomyces cerevisiae (P25621)
2.A.1.14.19	Plasma membrane, high affinity vitamin H transporter 1 (H⁺:biotin symporter), Vht1 (Stolz, 2003)	Yeast	Vht1 of Schizosaccharomyces pombe (O13880)
2.A.1.14.20	Endoplasmic reticular cysteine transporter, Yct1 (Kaur and Bachhawat, 2007)	Yeast	Yct1 of Saccharomyces cerevisiae (Q12235)
2.A.1.14.21	The vesicular purine nucleotide (ADP, ATP, GTP) transporter. (Found in synaptic vesicles and chromafin granules, SLC17A9 (Sawada et al., 2008)).	Animals	SLC17A9 of Homo sapiens (Q9BYT1)
2.A.1.14.22	The chloroplast thylakoid Na⁺:phosphate symporter, ANTR1 (512aas) (Pavón et al., 2008).	Plants	ANTR1 of Arabidopsis thaliana (O82390)
2.A.1.14.23	Vesicular glutamate transporter #3 (VGLUT3) [Its absence in mice causes sensorineural deafness and seizures]. 70% identical to VGLUT2 (TC# 2.A.1.14.16)	Animals	VGLUT3 of Mus musculus (Q8BFU8)
2.A.1.14.24	Intestinal mucosal sodium/phosphate symporter, SLC17A4. Maintains phosphate homeostasis; mediates intestinal absorption, bone deposition and resorption and renal excretion.	Animals	SLC17A4 (604216) of Homo sapiens (Q9Y2C5)
2.A.1.14.25	The putative D-mannuronate porter, AlgT	Proteobacteria	AlgT of Shewanella frigidimarina (Q07YH1)
2.A.1.15: The Aromatic Acid:H⁺ Symporter (AAHS) Family
2.A.1.15.1	4-Hydroxybenzoate/protocatachuate porter	Bacteria	PcaK of Pseudomonas putida
2.A.1.15.2	3-Hydroxyphenyl propionate porter	Bacteria	MhpT of E. coli
2.A.1.15.3	2,4-Dichlorophenoxyacetate porter	Bacteria	TfdK of Ralstonia eutropha
2.A.1.15.4	cis,cis-muconate porter, MucK	Bacteria	MucK of Acinetobacter sp. ADP1
2.A.1.15.5	Benzoate porter, BenK	Bacteria	BenK of Acinetobacter sp. ADPP1
2.A.1.15.6	Putative vanillate porter	Bacteria	VanK of Acinetobacter sp. ADP1
2.A.1.15.7	The putative niacin/nicotinamide uptake porter, NiaP or YceI (Rodionov et al., 2009 Rodionov et al., 2009)	Bacteria	YceI of Bacillus subtilis (O34691)
2.A.1.15.8	Probable 1-hydroxy-2-naphthoate transporter, orf1 (Iwabuchi and Harayama, 1997).	Bacteria	Orf1 of Nocardioides sp. (O24723)
2.A.1.15.9	Probable 4-methylmuconolactone transporter, MmlH (Erb et al., 1998)	Bacteria	MmlH of Ralstonia eutropha (O51798)
2.A.1.16: The Siderophore-Iron Transporter (SIT) Family
2.A.1.16.1	Siderophore-iron (ferrioxamine):H⁺ sym- porter, Sit1 (Arn3) (in vesicles)	Yeast	Sit1 (YEL065w) of Saccharomyces cerevisiae
2.A.1.16.2	The ferric enterobactin:H⁺ symporter, Enb1	Yeast	Enb1 (YOL158c) of Saccharomyces cerevisiae
2.A.1.16.3	The ferric triacetylfusarinine C:H⁺ symporter, Taf1	Yeast	Taf1 (YHL047c) of Saccharomyces cerevisiae
2.A.1.16.4	The ferrichrome:H⁺ symporter, Arn1p (Moore et al., 2003)	Yeast	Arn1 of Saccharomyces cerevisiae (NP_011823)
2.A.1.17: The Cyanate Porter (CP) Family
2.A.1.17.1	Cyanate transport system	Bacteria	CynX of E. coli
2.A.1.18: The Polyol Porter (PP) Family
2.A.1.18.1	D-Arabinitol:H⁺ symporter	Bacteria	DalT of Klebsiella pneumoniae
2.A.1.18.2	Ribitol:H⁺ symporter	Bacteria	RbtT of Klebsiella pneumoniae
*2.A.1.19: The Organic Cation Transporter (OCT) Family (The SLC22A family including OCT1-3, OCTN1-3 and OAT1-5 of H. sapiens)*
2.A.1.19.1	The basolateral multivalent, potential-sensitive, organic cation (tetramethyl-ammonium; N'-methylnicotinamide; cationic drugs, xenobiotics, vitamins, neuro-transmitters, etc.) transporter (uni-porter)-1, Oct1	Animals	Oct1 of Rattus norvegicus (Q63089)
2.A.1.19.2	The polyspecific organic cation (tetraethyl ammonium, guanidinium):putative H⁺ antiporter, OctN1	Animals	OctN1 of Homo sapiens (O14546)
2.A.1.19.3	The polyspecific organic cation (L- and D-carnitine, butyryl-L-carnitine, acetyl carnitine, γ-butyro-betaine, glycinebetaine, β-lactam anti-biotics with a quaternary nitrogen such as cephaloridine, and others):Na⁺ symporter, OctN2 (may also function as a uniporter for some organic cations)	Animals	OctN2 of Homo sapiens (O76082)
2.A.1.19.4	The polyspecific organic anion, cation and neutral molecule transporter, Oat1 (Slc22a6) (transports neutral compounds such as cardiac glycosides [i.e., ouabain] and steroids [i.e., aldosterone; cortisol; dexamethasone]; cationic compounds such as N-propylajmalinium, and anionic compounds such as p-aminohippurate, dicarboxylates, cyclic nucleotides, prostaglandins, urate, β-lactam antibiotics, nonsteroidal anti-inflammatory drugs, diuretics, bile salts and steroid conjugates [i.e., estrone-3-sulfate and estradiol-17- glucuronide]) transporter (H⁺ symporter or uniporter) Probably catalyzes organic anion (uptake):dicarboxylate (efflux) antiport in the basolateral membrane of kidney proximal tubules) (Eraly et al., 2003a,b). A 3-dimensional model of OAT1 has led to the identification of residues involved in differential transport of substrates such as p-aminohippurate and cidofovir (Perry et al., 2006). Oat1 transports many antiviral agents (Truong et al., 2008). The human orthologue (Q4U2R8; 563aas) has been shown to be a multispecific organic anion transporter on the basolateral membrane of the proximal tubule in human kidney (Hosoyamada et al. 1999).	Animals	Oat1 of Rattus norvegicus (O35956)
2.A.1.19.5	The putative apical polyspecific organic cation transporter (cation:H⁺ or cation:cation antiporter), Oct2 (substrates include monoamine neurotransmitters such as dopamine, noradrenaline, adrenaline and 5-hydroxytryptamine) (Oct2 exhibits some properties of an ion channel with an inner diameter of ~4 �. Selectivity: Cs⁺ > Rb⁺ > K⁺ > Na⁺ ≈ Li⁺ (Schmitt and Koepsell, 2005)) Chloride dependent, but a single mutation (R466K) abolishes this dependency (Rizwan et al., 2007). Also transports ochratoxin (Rizwan et al., 2007) and cisplatin and oxaliplatin (Yonezama et al., 2006).	Animals	Oct2 of Sus scrofa (O02713)
2.A.1.19.6	The polyspecific potential-sensitive organic cation uptake transporter, Oct3 (transport substrates include the neurotoxin 1-methyl- 4-phenylpyridinium and monoamine neuro- transmitters such as dopamine)	Animals	Oct3 of Rattus norvegicus (O88446)
2.A.1.19.7	The polyspecific organic anion (and cation) (anions: p-aminohippurate, ochratoxin A, estrone sulfate, anionic drugs, anionic neurotransmitter metabolites; cation: cimetidine) transporter, Oat3 (slc22a8) (catalyzes organic anion (uptake): dicarboxylate (efflux) antiport in the basolateral membrane of the renal proximal tubule) (Eraly et al., 2003a,b); transports many antiviral agents (Truong et al., 2008).	Animals	Oat3 of Rattus norvegicus (Q9R1U7)
2.A.1.19.8	The mouse organic cation transporter, mBOCT (transports various cations and anions including cyclic GMP)	Animals	mBOCT of Mus musculus (Q9WTM1)
2.A.1.19.9	The osteosclerosis protein, Roct (organic anion transporter 3, Oat3) (Slc22a8) (catalyzes organic anion (uptake):di-carboxylate (efflux) antiport in the basolateral membrane of the renal proximal tubule) (Eraly et al., 2003a,b); transports glutathione and many antiviral agents (Truong et al., 2008).	Animals	Roct (Oat3) of Mus musculus (O88909)
2.A.1.19.10	The apical proximal tubular kidney/placenta organic anion transporter 4, Oat4 (Slc22a11) (transports estrone sulfate (K_m = 1 �M), dehydroepiandrosterone sulfate (K_m = 60�M), many anionic drugs, diuretics, bile salts, and ochratoxin A) (catalyzes Na⁺-independent efflux).	Animals	Oat4 of Homo sapiens (Q9NSA0)
2.A.1.19.11	The apical proximal tubular renal urate:anion exchanger, URAT1 (Slc22a12) (catalyzes Na⁺-independent anion efflux (secretion)) (Eraly et al., 2003a,b) (regulated by PDZK1 protein; Anzai et al., 2004) Mutations in URAT1 cause hereditary renal hypouricemia.	Animals	URAT1 of Homo sapiens (Q96S37)
2.A.1.19.12	The high affinity L-carnitine transporter, CT2 (present in the luminal membranes of epididymal epithelia and Sertoli cells of the testis) (Enomoto et al., 2002b)	Animals	CT2 of Homo sapiens (Q8IUG8)
2.A.1.19.13	The organic cation transporter, Oct1 (transports L-carnitine; expressed in vascular tissues of various organs and at sites of lateral root formation) (Lelandais-Briere et al, 2007)	Plants	Oct1 of Arabidopsis thaliana (Q9CAT6)
2.A.1.19.14	Brush boarder glycosylated urate (Km= 1.2 mM) tranporter. Inhibited by 50 μM benzbromarone, 1 mM probenecid and 10 mM lactate which may also be transported and trans-stimulate urate uptake. May be orthologous to 2.A.1.19.11. (Hosoyamada et al., 2004).	Animals	URAT1 of Mus musculus (Q8CFZ5)
2.A.1.19.15	The liver multispecific organic anion transporter, NLT or OAT2. Transports salicylate, K_M=90�M, acetylsalicylate, prostaglandin E2, dicarboxylate, p-aminohippurate, etc. (Sekine et al., 1998)	Animals	NLT of Rattus norvegicus (Q63314)
2.A.1.19.16	The organic anion transporter, Oat6 (binding and transport rates for 40 anionic substrates were studied and compared with these for Oat1 (TC# 1.A.1.19.4) (Kaler et al., 2007); transports many antiviral agents (Truong et al., 2008).	Animal	Oat6 of Mus musculus (Q80UJ1)
2.A.1.19.17	Kidney organic cation transporter-like 3 ORCTL-3 (OAT10; SLC22A13) (Bahn et al., 2008) (transports nicotinate, p-aminohippurate and urate; K_M=20-40 mμM) via exchange for lactate).	Animals	ORCTL-3 of Homo sapiens (Q9Y226)
2.A.1.19.18	Oranic anion transporter, Oat7 (exchanges sulfate conjugates (steroids) and other anions for butyrate) (Shin et al., 2007)	Animals	Oat7 of Homo sapiens (Q8IVM8)
2.A.1.19.19	The rat kidney basolateral potential-driven symport carrier, Oct2 (transports tetraethylammonium and many other organic cations) (Sweet and Pritchard 1999).	animals	Oct2 of Rattus norvegicus (Q9R0W2)
2.A.1.20: The Sugar Efflux Transporter (SET) Family
2.A.1.20.1	Efflux system for lactose, glucose, aromatic glucosides and galactosides, cellobiose, maltose, α-methylglucoside, and isopropyl β-thiogalactosides (IPTG); amino-glycosides, streptomycin and kanamycin, weakly expelled	Bacteria	SetA (YabM) of E. coli
2.A.1.20.2	Efflux system for lactose and glucose, but not IPTG or galactose	Bacteria	SetB (YeiO) of E. coli
2.A.1.20.3	Putative efflux system for unknown substrates (none of those exported by SetA and SetB are exported by SetC)	Bacteria	SetC (YicK) of E. coli
2.A.1.20.4	Efflux system for arabinose and IPTG (>>lactose), SotA	Bacteria	SotA of Erwinia chrysanthemi
2.A.1.21: The Drug:H⁺ Antiporter-3 (12 Spanner) (DHA3) Family
2.A.1.21.1	The macrolide (erythromycin; oleando-mycin; azithromycin) efflux, MefA	Bacteria	MefA of Streptococcus pyogenes
2.A.1.21.2	The multidrug (erythromycin, tetracycline, puromycin, bleomycin) resistance protein, Cmr	Bacteria	Cmr of Corynebacterium glutamicum
2.A.1.21.3	The tetracycline resistance determinant, TetV	Bacteria	TetV of Mycobacterium smegmatis
2.A.1.21.4	Multidrug resistance efflux pump, Tap	Bacteria	Tap of Mycobacterium fortuitum
2.A.1.21.5	The putative bacilysin exporter, BacE	Bacteria	BacE of Bacillus subtilis (P39642)
2.A.1.21.6	The tetracycline resistance efflux pump, TetA(P) (Bannam et al., 2004) (21% identity (e^-07) with 2.A.1.21.5 and 22% identity (2xe^-7) with 2.A.1.2.10). It may be the link between DHA1 and DHA3.	Bacteria	TetA (P) of Clostridium perfringens (Q46305)
2.A.1.21.7	The Staphyloferrin A (siderophore) exporter, NWMN-2081 (Beasley et al. 2009).	Bacteria	NWMN-2081 of Staphylococcus aureus (A6QJ21)
2.A.1.21.8	The putative macrolide exporter, TIGR00900 (most similar to 2.A.1.21.1).	Bacteria	TIGR00900 of Bacillus clausii (Q5WAS7)
2.A.1.22: The Vesicular Neurotransmitter Transporter (VNT) Family (Related to the SP Family (TC #2.1.1))
2.A.1.22.1	Synaptic vesicle neurotransmitter (e.g., dopamine) transporter	Animals	SV2 of Rattus norvegicus
2.A.1.23: The Conjugated Bile Salt Transporter (BST) Family
2.A.1.23.1	Conjugated bile salt:H⁺ symporter, CbsT1	Bacteria	CbsT1 of Lactobacillus johnsonii 100-100
2.A.1.23.2	Taurocholate:cholate antiporter, CbsT2	Bacteria	CbsT2 of Lactobacillus johnsonii 100-100 (AAC34380)
2.A.1.24: The Unknown Major Facilitator-1 (UMF1) Family
2.A.1.24.1	58.8 KDa protein, YCL038c	Yeast	YCL038c of Saccharomyces cerevisiae
2.A.1.25: The Peptide-Acetyl-Coenzyme A Transporter (PAT) Family
2.A.1.25.1	(Putative) Acetyl-CoA:CoA antiporter	Animals	Acetyl CoA transporter of Homo sapiens
2.A.1.25.2	Cell wall degradation product (peptides and glycopeptides including N-acetylglucos-aminyl β-1,4-anhydro-N-acetyl-muramyl-tripeptide) as well as penicillin derivative uptake porter, AmpG	Bacteria	AmpG of E. coli (P0AE16)
2.A.1.25.3	The AmpG peptidoglycan uptake porter; part of the peptidoglycan recycling pathway (Garcia and Dillard, 2008)	Bacteria	AmpG of Neisseria gonorrhoeae (Q5F6G0)
2.A.1.26: The Unknown Major Facilitator-2 (UMF2) Family
2.A.1.26.1	41.4 KDa Protein, YcaD	Bacteria	YcaD of E. coli
2.A.1.27: The Phenyl Propionate Permease (PPP) Family
2.A.1.27.1	The phenylpropionate porter, HcaT	Bacteria	HcaT (YfhS) of E. coli
2.A.1.28: The Feline Leukemia Virus Subgroup C Receptor (FLVCR) Family
2.A.1.28.1	Cell surface receptor (c-receptor) for anemia-inducing feline leukemia virus subgroup C (FLCVR); functions in haem export in haemopoietic cells (Latunde-Dada et al., 2006). May cause Diamond-Blackfan anemia when defective (Keel et al., 2008).	Animals	C-receptor of Homo sapiens
2.A.1.28.2	The MFS-Domain7 protein (516aa) (the MFS-D7 mRNA is expressed in many human tissues, especially in lungs and testis).	Animals	MFSD7 of Mus musculus
2.A.1.29: The Unknown Major Facilitator-4 (UMF4) Family
2.A.1.29.1	Archaeal open reading frame	Archaea	Orf of Archaeoglobus fulgidus
2.A.1.29.2	Archaeal open reading frame	Archaea	Orf of Aeropyrum pernix
2.A.1.30: The Putative Abietane Diterpenoid Transporter (ADT) Family
2.A.1.30.1	Putative abietane uptake permease (in gene cluster for degradation of abietane diterpenoids), DitE	Bacteria	DitE of Pseudomonas abietaniphila BKME-9
2.A.1.31: The Nickel Resistance (Nre) Family
2.A.1.31.1	The Ni²⁺ efflux pump, NreB (Ni²⁺ inductible)	Bacteria	NreB of Achromobacter xylosoxidans plasmid pTOM
2.A.1.31.2	The Ni²⁺ resistance protein, NrsD	Bacteria	NrsD of Synechocystis PCC6803
2.A.1.32: The Putative Aromatic Compound/Drug Exporter (ACDE) Family
2.A.1.32.1	Putative aromatic compound/drug exporter	Bacilli	YitG of Bacillus subtilis
2.A.1.32.2	Bacillibactin exporter, YmfE (199aas; 6TMSs) (Miethke et al., 2008) (resembles the 2^nd half of YitG of B. subtilis (2.A.1.32.1). The sequence provided under acc# O31763 is only a fragment of the full length gene.	Bacteria	YmfE of Bacillus subtilis (O31763)
2.A.1.33: The Putative YqgE Transporter (YqgE) Family
2.A.1.33.1	MFS homologue, YqgE	Bacteria; Archaea	YqgE of Bacillus subtilis
2.A.1.35: The Fosmidomycin Resistance (Fsr) Family
2.A.1.35.1	The fosmidomycin resistance (Fsr) protein (confers fosmidomycin, trimethoprim and carbonylcyanide m-chlorophenylhydrazone (CCCP) resistance)	Bacteria	Fsr of E. coli
2.A.1.35.2	The cationic microbial peptide resistance (RosA) protein	Bacteria	RosA of Yersinia enterocolitica
2.A.1.36: The Acriflavin-sensitivity (YnfM) Family
2.A.1.36.1	The acriflavin-sensitivity protein, YnfM (increases sensitivity to acriflavin specifically)	Bacteria	YnfM of E. coli
2.A.1.38: The Enterobactin (Siderophore) Exporter (EntS) Family
2.A.1.38.1	The enterobactin (siderophore) exporter, EntS (Bleuel et al., 2005)	Bacteria	EntS (YbdA) of E. coli
2.A.1.38.2	The putative siderophore exporter (DUF 894; Pfam 05977), VabS	Bacteria	VabS of Listonella anguillarum (Q0E7C5)
2.A.1.38.3	Enterobactin exporter, EntS (Crouch et al., 2008) (probably orthologous to 2.A.1.38.1).	Bacteria	EntS of Salmonella typhimurium (Q8ZR35)
2.A.1.39: The Vibrioferrin (Siderophore) Exporter (PrsC) Family
2.A.1.39.1	The vibrioferrin (siderophore) exporter, PrsC (Tanabe et al., 2003)	Bacteria	PrsC of Vibrio parahaemolyticus (BAC16546)
2.A.1.40: The Purine Transporter, AzgA (AzgA) Family
2.A.1.40.1	The purine (hypoxanthine/adenine/guanine) transporter, AzgA (Cecchetto et al., 2004).	Fungi	AzgA of Aspergillus (Emericella) nidulans (CAE00849)
2.A.1.40.2	Hypoxanthine/guanosine uptake transporter, PbuG (Johansen et al., 2003)	Bacteria	PbuG of Bacillus subtilis (CAB12456)
2.A.1.40.3	The purine transporter Azg1 (takes up 8-azadenine and 8-azaguanine but not other toxic nucleobase analogues; similar to Azg2 of A. thaliana (Q84MA8); (Mansfield et al. 2009).	Plants	Azg1 of Arabidopsis thaliana (Q9SRK7)
2.A.1.41: The Putative Bacteriochlorophyll Delivery (BCD) Family
2.A.1.41.1	Putative pigment transporter (Young and Beatty, 1998)	Photosynthetic bacteria	LhaA of Rhodobacter capsulatus
2.A.1.41.2	Putative pigment transporter (Young and Beatty, 1998)	Photosynthetic bacteria	PucC of Rhodobacter capsulatus
2.A.1.41.3	Putative bacteriochlorophyll synthase	Photosynthetic bacteria	Bch2 of Rhodobacter capsulatus
2.A.1.42: The Lysophospholipid Transporter (LplT) Family
2.A.1.42.1	The lysophospholipid transporter, LplT (Harvat et al., 2005)	Bacteria	LplT of E. coli (NP_417312)
2.A.1.42.2	The putative lysophospholipid transporter-2-acyl glycerophosphoethanolamine acyl transferase/acyl ACP synthetase (LplT-Pls-ACS) fusion protein (Harvat et al., 2005).	Bacteria	The fused LplT-PlsC-ACS of Bradyrhizobium japonicum (BAC47589)
2.A.1.43: The Putative Magnetosome Permease (PMP) Family
2.A.1.43.1	The putative magnetosomal permease, MamH (Schubbe et al., 2003)	Bacteria	MamH of Magnetospirillum gryphiswaldense (Q6NE63)
2.A.1.43.2	The putative magnetosome (Fe?) permease fused to a C-terminal YedZ-like domain (von Rozycki et al., 2004) This protein has a C-terminal YedZ domain and is therefore in the YedZ superfamily.	Bacteria	PMP of Magnetospirillum magnetotacticum (gi_23014927)
2.A.1.44: The L-Amino Acid Transporter-3 (LAT3) Family (also called the SLC43 family)
2.A.1.44.1	The L-amino acid transporter-3, LAT3 (transports neutral amino acids such as L-leucine, L-isoleucine, L-valine, and L-phenylalanine by a Na⁺-independent, electroneutral, facilitated diffusion process; also transports amino acid alcohols) (Prostate cancer up-regulated gene product)	Animals	LAT3 (POV1) of Homo sapiens (O75387)
2.A.1.44.2	L-amino acid transporter-4 (LAT4) has the same specificity and is 57% identity to LAT3. Na⁺, Cl^- and pH independent; not trans-stimulated; two kinetic components, a low affinity component sensitive to NEM, and a high affinity component insensitive to NEM. Found in the basolateral membrane of epithelial cells in the distal tubule and collecting duct of the kidney and the crypt cells in the intestine (Bodoy et al., 2005).	Animals	LAT4 of Homo sapiens (DAA05676)
2.A.1.45: The 2,4-diacetylphloroglucinol (PHL) Exporter (PHL-E) Family
2.A.1.45.1	The 2,4-diacetylphloroglucinol resistance/general stress porter, PhlE (Abbas et al., 2004)	Bacteria	PhlE of Pseudomonas fluorescens (CAD65845)
2.A.1.46: The Unknown Major Facilitator-5 (UMF5) Family
2.A.1.46.1	Probable transporter	Bacteria	Probable transporter of Bordetella pertussis (Q7W0Q7)
2.A.1.46.2	Putative transporter	Bacteria	Putative transporter of Tropheryma whipplei (Q83N16)
2.A.1.47: The Unknown Major Facilitator-6 (UMF6) Family
2.A.1.47.1	Putative transporter	Bacteria	Putative transporter of Lactobacillus plantarum (NP_784357)
2.A.1.48: The Vacuolar Basic Amino Acid Transporter (V-BAAT) Family
2.A.1.48.1	The vacuolar basic amino acid (histidine, lysine and arginine) transporter, Vba1 (catalyzes uptake into the vacuoles (equivalent to efflux from the cytoplasm)) (most similar to family 2.A.1.3; DHA2; 13-14 putative TMSs) (Shimazu et al., 2005)	Yeast	Vba1 of Saccharomyces cerevisiae (NP_013806)
2.A.1.48.2	The vacuolar basic amino acid (Arg, Lys, His) transporter, Vba2 (Shimazu et al., 2005)	Yeast	Vba2 of Saccharomyces cerevisiae (P38358)
2.A.1.48.3	Vacuolar G0 arrest protein, Fnx1; involved in amino acid (e.g., his, lys, ile, asn, etc) uptake into the vacuole (Chardwiriyapreecha et al., 2008).	Yeast	Fnx1 of Schizosaccharomyces pombe (Q09752)
2.A.1.48.4	Vacuolar amino acid uptake system, Fnx2 (Chardiwiriyapreecha et al., 2008)	Yeast	Fnx2 of Schizosaccharomyces pombe (O59726)
2.A.1.49: The Endosomal Spinster (Spinster) Family
2.A.1.49.1	The spinster protein, spin1 gene product (involved in synaptic growth regulation; interacts with Bcl-2/Bcl-xL, affecting programmed cell death) (Nakano et al., 2001; Sanyal and Ramaswami, 2002; Yanagisawa et al., 2003)	Animals	Spinster of Drosophila melanogaster (AAG43825)
2.A.1.49.2	The spinster homologue, Spin1 (interacts with Bc1-2/Bc1-XL to induce a caspase-independent autophagic cell death; may be required for embryogenesis) (Yanagisawa et al., 2003)	Animals	Spin1 of Homo sapiens (NP_114427)
2.A.1.50: The Proton Coupled Folate Transporter/Heme Carrier Protein (PCFT/HCP) Family
2.A.1.50.1	The apical intestinal proton coupled, high affinity folate transporter, the hereditary folate malabsorption protein, PCFT/HCP1 (Also reported to mediate heme-iron uptake from the gut lumen with duodenal epithelial cells (Shayeghi et al., 2005; Latunde-Dada et al., 2006; Subramanian et al., 2008), but it shows a higher affinity for folate than heme) (Qiu et al., 2006). Responsible for folate uptake by choroid plexus epithelial cells (Wollack et al., 2007) and placenta (Yasuda et al., 2008). The rat orthologue (Q5EBA8) catalyzes H⁺-dependent folate uptake in the intestine (Inoue et al., 2008). Responsible for the rare autosomal recessive disorder, hereditary folate malabsorption (Zhao and Goldman, 2007).	Animals	PCFT/HCP1 of Homo sapiens (Q96NT5)
2.A.1.50.2	Thymic stromal cotransporter, TSCOT (Kim et al. 2000)	Animals	TSCOT of Homo sapiens (Q9BY10)
2.A.1.51: The Unknown Major Facilitator 7 (UMF7) Family
2.A.1.51.1	Putative permease	Bacteria	Putative transporter of Azoarcus sp. EbN1 (CAI06874)
2.A.1.52: The Unknown Major Facilitator-8 (UMF8) Family
2.A.1.52.1	The putative permease, YihN (most like NarK and UhpC, 21% identity)	Bacteria	YihN of E. coli (P32135)
2.A.1.53: The Proteobacterial Intraphagosomal Amino Acid Transporter (Pht) Family
2.A.1.53.1	The threonine uptake permease, PhtA (Sauer et al., 2005) (required for maximal growth in macrophages and Acanthamoeba castellanii)	Gamma proteobacteria	PhtA of Legionella pneumophila (YP_094583)
2.A.1.53.2	The valine uptake permease, PhtJ (required for maximal growth in macrophages and Acanthamoeba castellanii)(Chen et al., 2008)	Gamma proteobacteria	PhtJ of Legionella pneumophila (YP_095910)
2.A.1.53.3	The putative MFSDI transporter (463aas; 12 TMSs)	Animals	MFSDI of Homo sapiens (A6NID9)
2.A.1.54: The Unknown (Archaeal/Bacterial) Major Facilitator-9 (UMF9) Family
2.A.1.54.1	The archaeal uptake permease, MMP0835 (function unknown) (31% I, 49% S with PhtA)	Bacteria	MMP0835 of Methanococcus maripaludis (CAF30391)
2.A.1.55: The Iron � Pyridine Thiocarboxylic Acid Transporter (PDTC-T) Family
2.A.1.55.1	The iron (Fe³⁺) � pyridine-2,6-bis(thiocarboxylic acid (PDTC)) uptake transporter, PdTE. Functions with the OMR, PdtK, 1.B.14.8.2 (most similar to 2.A.1.25.2, AmpG).	Bacteria	PdtE of Pseudomonas putida (ABC8353)
2.A.1.56: The 1,3-Dihydroxybenzene Transporter (DHB-T) Family
2.A.1.56.1	The 1,3-dihydroxybenzene (resorcinol) uptake permease, MFS_1 (Darley et al., 2007)	Bacteria	MFS_1 of Azoarcus anaerobius (YP_285101)
2.A.1.57: The Ferripyochelin Transporter (FptX) Family
2.A.1.57.1	The Ferripyochelin uptake permease, FptX (most similar to 1.A.1.25) (Michel et al., 2007).	Bacteria	FptX of Pseudomonas aeruginosa (Q9HWG8)
2.A.1.58: The N-Acetylglucosamine Transporter (NAG-T) Family
2.A.1.58.1	The N-acetylglucosamine H⁺ symporter, Ngt1 (Alvarez and Konopka, 2007)	Yeast	Ngt1 of Candida albicans (Q5A7S4)
2.A.1.59: Unidentified Major Facilitator-10 (UMF10) Family (mostly from Archaea but some from bacteria)
2.A.1.59.1	UMF10a of unknown function (most similar, (22% identity)) to TC# 2.A.1.3.25 and 2.A.1.2.24) (COG2270)	Archaea	UMF10a of Methanococcus aeolicus (A6UVW2)
2.A.1.60: The Rhizopine-related MocC (MocC) Family
2.A.1.60.1	The rhizopine related transporter, MocC (could either transport a precursor for rhizopine biosynthesis into bacteroids or the finished product from the bacteroids) (Murphy et al., 1993)	Bacteria	MocC of Sinorhizobium meliloti (Q07609)
2.A.1.61: The Microcin C51 Immunity Protein (MccC) Family
2.A.1.61.1	The MccC microcin C51 immunity protein (exports the peptide-nucleotide 'Trojan horse' antibiotic) (Fomenko et al., 2003; Kazakov et al., 2007)	Bacteria	MccC of E. coli (Q83Y57)
2.A.1.62: The Unidentified Major Facilitator-11 (UMF11) Family
2.A.1.62.1	The UMF11 homologue (most similar to 2.A.1.38.2 and 2.A.1.21.1) (18% identity; 38% similarity)	Protein	UMF11 of UMF11 of Staphylococcus aureus (A8YZ14)
2.A.1.63: The Unidentified Major Facilitator-12 (UMF12) Family
2.A.1.63.1	The UMF12 protein (most similar to 2.A.1.46.1)	Archaea	UMF12 of Methanosarcina barkeri (Q467Y6)
2.A.1.64: The Unidentified Major Facilitator-13 (UMF13) Family
2.A.1.64.1	The UMF13 protein (most similar to 2.A.1.24.1)	Firmicutes	UMF13 of Streptococcus pneumoniae (Q5M4L1)
2.A.1.65: The Unidentified Major Facilitator-14 (UMF14) Family
2.A.1.65.1	The putative MFS carrier, Sugar Baby (Sug, isoform D); has a hydrophilic domain between TMSs 3 and 4. Overexpression causes an increased lifespan by 17%.	Animals	Sugar Baby of Drosophila melanogaster (Q7KUF9)
2.A.1.65.2	Unknown MFS homologue; e^-6 with 2.A.1.5 family members; has a hydrophilic domain between TMSs 3 and 4.	Animals	UMF14 of Culex quinquefasciatus (B0W435)
2.A.1.66: The Unidentified Major Facilitator-15 (UMF15) Family
2.A.1.66 The Unidentified Major Facilitator-15 (UMF15) Family
2.A.1.66.1	MFS permease of unknown function (First half resembles 2.A.1.3.7 (e-11) and 2.A.1.15.3 (e-8))	Archaeon	MFS permease of Thermofilum pendens (A1RW34)