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2.A.1.1.1
Galactose:H+ symporter, GalP. Also transports glucose, xylose, fucose (6-deoxygalactose), 2-deoxygalactose and 2-deoxyglucose) (Henderson and Giddens 1977Henderson et al. 1977; Hernández-Montalvo et al., 2001). Relative substrate affinities of wild-type and mutant forms of the E. coli sugar transporter GalP have been determined by solid-state NMR (Patching et al., 2008).  GalP may exist as a trimer with each subunit having a sugar transporting channel (Zheng et al. 2010).

Accession Number:P0AEP1
Protein Name:Galactose-proton symporter
Length:464
Molecular Weight:50983.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate D-galactose, Galactose

Cross database links:

Genevestigator: P0AEP1 P0AEP1 P0AEP1
EchoBASE: EB2068 EB2068 EB2068
EcoGene: EG12148 EG12148 EG12148
eggNOG: COG0477 COG0477 COG0477
HEGENOM: HBG744444 HBG744444 HBG744444

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPDAKKQGRS NKAMTFFVCF LAALAGLLFG LDIGVIAGAL PFIADEFQIT SHTQEWVVSS 
61:	MMFGAAVGAV GSGWLSFKLG RKKSLMIGAI LFVAGSLFSA AAPNVEVLIL SRVLLGLAVG 
121:	VASYTAPLYL SEIAPEKIRG SMISMYQLMI TIGILGAYLS DTAFSYTGAW RWMLGVIIIP 
181:	AILLLIGVFF LPDSPRWFAA KRRFVDAERV LLRLRDTSAE AKRELDEIRE SLQVKQSGWA 
241:	LFKENSNFRR AVFLGVLLQV MQQFTGMNVI MYYAPKIFEL AGYTNTTEQM WGTVIVGLTN 
301:	VLATFIAIGL VDRWGRKPTL TLGFLVMAAG MGVLGTMMHI GIHSPSAQYF AIAMLLMFIV 
361:	GFAMSAGPLI WVLCSEIQPL KGRDFGITCS TATNWIANMI VGATFLTMLN TLGNANTFWV 
421:	YAALNVLFIL LTLWLVPETK HVSLEHIERN LMKGRKLREI GAHD