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2.A.1.1.104
Myo-inositol transporter 2

Accession Number:P30606
Protein Name:Myo-inositol transporter 2
Length:609
Molecular Weight:66710.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate myo-inositol

Cross database links:

Genevestigator: P30606
eggNOG: COG0477
HEGENOM: HOG000202868
DIP: DIP-6553N
Entrez Gene ID: 854050   
Pfam: PF00083   
KEGG: sce:YOL103W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005365 F:myo-inositol transmembrane transporter activity

References (7)

[1] “Isolation and characterization of two distinct myo-inositol transporter genes of Saccharomyces cerevisiae.”  Nikawa J.et.al.   2040626
[2] “Sequence analysis of a 44 kb DNA fragment of yeast chromosome XV including the Ty1-H3 retrotransposon, the suf1(+) frameshift suppressor gene for tRNA-Gly, the yeast transfer RNA-Thr-1a and a delta element.”  Vandenbol M.et.al.   7502582
[3] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.”  Dujon B.et.al.   9169874
[4] “Mutational analysis and localization of the inositol transporters of Saccharomyces cerevisiae.”  Miyashita M.et.al.   16233524
[5] “Sequencing and comparison of yeast species to identify genes and regulatory elements.”  Kellis M.et.al.   12748633
[6] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[7] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKNSTAASSR WTKSRLSHFF PSYTNSSGMG AASTDQSSTQ GEELHHRKHC EEDNDGQKPK 
61:	KSPVSTSTMQ IKSRQDEDED DGRIVIKPVN DEDDTSVIIT FNQSISPFII TLTFVASISG 
121:	FMFGYDTGYI SSALISINRD LDNKVLTYGE KELITAATSL GALITSVGAG TAADVFGRRP 
181:	CLMFSNLMFL IGAILQITAH KFWQMAAGRL IMGFGVGIGS LISPLFISEI APKMIRGRLT 
241:	VINSLWLTGG QLIAYGCGAG LNHVKNGWRI LVGLSLIPTV LQFSFFCFLP DTPRYYVMKG 
301:	DLKRAKMVLK RSYVNTEDEI IDQKVEELSS LNQSIPGKNP ITKFWNMVKE LHTVPSNFRA 
361:	LIIGCGLQAI QQFTGWNSLM YFSGTIFETV GFKNSSAVSI IVSGTNFVFT LIAFFCIDKI 
421:	GRRYILLIGL PGMTVALVIC AIAFHFLGIK FNGADAVVAS DGFSSWGIVI IVFIIVYAAF 
481:	YALGIGTVPW QQSELFPQNV RGVGTSYATA TNWAGSLVIA STFLTMLQNI TPTGTFSFFA 
541:	GVACLSTIFC YFCYPELSGL ELEEVQTILK DGFNIKASKA LAKKRKQQVA EGAAHHKLKF 
601:	EPTQEIVES