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2.A.1.1.108
Low-affinity glucose transporter HXT1

Accession Number:P32465
Protein Name:Low-affinity glucose transporter HXT1
Length:570
Molecular Weight:63261.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate glucose

Cross database links:

Genevestigator: P32465
eggNOG: COG0477
HEGENOM: HOG000202870
DIP: DIP-5593N
Entrez Gene ID: 856494   
Pfam: PF00083   
KEGG: sce:YHR094C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005624 C:membrane fraction
GO:0005886 C:plasma membrane
GO:0005353 F:fructose transmembrane transporter activity
GO:0005354 F:galactose transmembrane transporter activity
GO:0005355 F:glucose transmembrane transporter activity
GO:0015578 F:mannose transmembrane transporter activity
GO:0015146 F:pentose transmembrane transporter activity

References (9)

[1] “The HXT1 gene product of Saccharomyces cerevisiae is a new member of the family of hexose transporters.”  Lewis D.A.et.al.   2046678
[2] “Roles of multiple glucose transporters in Saccharomyces cerevisiae.”  Ko C.H.et.al.   8417358
[3] “Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII.”  Johnston M.et.al.   8091229
[4] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[5] “A proteomics approach to understanding protein ubiquitination.”  Peng J.et.al.   12872131
[6] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258
[7] “Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.”  Li X.et.al.   17330950
[8] “Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.”  Chi A.et.al.   17287358
[9] “A multidimensional chromatography technology for in-depth phosphoproteome analysis.”  Albuquerque C.P.et.al.   18407956

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNSTPDLISP QKSNSSNSYE LESGRSKAMN TPEGKNESFH DNLSESQVQP AVAPPNTGKG 
61:	VYVTVSICCV MVAFGGFIFG WDTGTISGFV AQTDFLRRFG MKHHDGSHYL SKVRTGLIVS 
121:	IFNIGCAIGG IVLAKLGDMY GRRIGLIVVV VIYTIGIIIQ IASINKWYQY FIGRIISGLG 
181:	VGGITVLSPM LISEVAPSEM RGTLVSCYQV MITLGIFLGY CTNFGTKNYS NSVQWRVPLG 
241:	LCFAWALFMI GGMMFVPESP RYLVEAGRID EARASLAKVN KCPPDHPYIQ YELETIEASV 
301:	EEMRAAGTAS WGELFTGKPA MFQRTMMGIM IQSLQQLTGD NYFFYYGTIV FQAVGLSDSF 
361:	ETSIVFGVVN FFSTCCSLYT VDRFGRRNCL MWGAVGMVCC YVVYASVGVT RLWPNGQDQP 
421:	SSKGAGNCMI VFACFYIFCF ATTWAPIAYV VISECFPLRV KSKCMSIASA ANWIWGFLIS 
481:	FFTPFITGAI NFYYGYVFMG CMVFAYFYVF FFVPETKGLS LEEVNDMYAE GVLPWKSASW 
541:	VPVSKRGADY NADDLMHDDQ PFYKSLFSRK