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2.A.1.1.11
General α-glucoside:H+ symporter, Gtr3, Mal11,Mal1T, Mtp1 or Agt1 . (Substrates include trehalose, maltotriose, maltose, turanose, isomaltose, α-methyl-glucoside, maltotriose, palatinose, and melezitose) (Smit et al., 2008).  Maltotriose is transported with higher affinity than maltose (Magalhães et al. 2016).

Accession Number:P53048
Protein Name:AGT1 aka MTP1 aka MAL1T aka MAL11 aka YGR289C
Length:616
Molecular Weight:67980.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate H+, alpha-glucosides

Cross database links:

Genevestigator: P53048
eggNOG: fuNOG07577
HEGENOM: HBG328361
DIP: DIP-5567N
RefSeq: NP_011805.1   
Entrez Gene ID: 853207   
Pfam: PF00083   
KEGG: sce:YGR289C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005352 F:alpha-glucoside:hydrogen symporter activity
GO:0005364 F:maltose:hydrogen symporter activity
GO:0015574 F:trehalose transmembrane transporter activity
GO:0000023 P:maltose metabolic process
GO:0015768 P:maltose transport
GO:0055085 P:transmembrane transport
GO:0015771 P:trehalose transport

References (6)

[1] “Characterization of AGT1 encoding a general alpha-glucoside transporter from Saccharomyces.”  Han E.-K.et.al.   8594329
[2] “Sequence analysis of a near-subtelomeric 35.4 kb DNA segment on the right arm of chromosome VII from Saccharomyces cerevisiae carrying the MAL1 locus reveals 15 complete open reading frames, including ZUO1, BGL2 and BIO2 genes and an ABC transporter gene.”  Volckaert G.et.al.   9090054
[3] “The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.”  Tettelin H.et.al.   9169869
[4] “Concurrent knock-out of at least 20 transporter genes is required to block uptake of hexoses in Saccharomyces cerevisiae.”  Wieczorke R.et.al.   10618490
[5] “Characterization of the putative maltose transporters encoded by YDL247w and YJR160c.”  Day R.E.et.al.   12210897
[6] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKNIISLVSK KKAASKNEDK NISESSRDIV NQQEVFNTED FEEGKKDSAF ELDHLEFTTN 
61:	SAQLGDSDED NENVINEMNA TDDANEANSE EKSMTLKQAL LKYPKAALWS ILVSTTLVME 
121:	GYDTALLSAL YALPVFQRKF GTLNGEGSYE ITSQWQIGLN MCVLCGEMIG LQITTYMVEF 
181:	MGNRYTMITA LGLLTAYIFI LYYCKSLAMI AVGQILSAIP WGCFQSLAVT YASEVCPLAL 
241:	RYYMTSYSNI CWLFGQIFAS GIMKNSQENL GNSDLGYKLP FALQWIWPAP LMIGIFFAPE 
301:	SPWWLVRKDR VAEARKSLSR ILSGKGAEKD IQVDLTLKQI ELTIEKERLL ASKSGSFFNC 
361:	FKGVNGRRTR LACLTWVAQN SSGAVLLGYS TYFFERAGMA TDKAFTFSLI QYCLGLAGTL 
421:	CSWVISGRVG RWTILTYGLA FQMVCLFIIG GMGFGSGSSA SNGAGGLLLA LSFFYNAGIG 
481:	AVVYCIVAEI PSAELRTKTI VLARICYNLM AVINAILTPY MLNVSDWNWG AKTGLYWGGF 
541:	TAVTLAWVII DLPETTGRTF SEINELFNQG VPARKFASTV VDPFGKGKTQ HDSLADESIS 
601:	QSSSIKQREL NAADKC