TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.1.1.12
  Glucose uniporter, Glut3 (also transports dehydro-ascorbate; Maulén et al., 2003). Down-regulated in the brains of Alzheimer's disease patients (Liu et al., 2008b).  The structure of the human orthologue with D-glucose bound was solved at 1.5 Å resolution in the outward occluded conformation (Deng et al. 2015).  Sugars are predominantly coordinated by polar residues in the C-terminal domain. The conformational transition from the outward-open to the outward-occluded states entails a prominent local rearrangement of the extracellular part of  TMS 7. Comparison of the outward-facing GLUT3 structures with inward-open GLUT1 provides insight into the alternating access cycle for GLUTs, whereby the C-terminal domain provides the primary substrate-binding site and the N-terminal domain undergoes rigid-body rotation with respect to the C-terminal domain (Deng et al. 2015).

Accession Number:Q07647
Protein Name:Gtr3 aka Glut3 aka SLC2A3 aka GLUT-3
Length:493
Molecular Weight:53581.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate glucose

Cross database links:

Genevestigator: Q07647
eggNOG: roNOG09613
RefSeq: NP_058798.2   
Entrez Gene ID: 25551   
Pfam: PF00083   
KEGG: rno:25551   

Gene Ontology

GO:0005901 C:caveola
GO:0016021 C:integral to membrane
GO:0030672 C:synaptic vesicle membrane
GO:0055056 F:D-glucose transmembrane transporter activity
GO:0033300 F:dehydroascorbic acid transporter activity
GO:0016936 F:galactoside binding
GO:0005536 F:glucose binding
GO:0019900 F:kinase binding
GO:0033222 F:xylose binding
GO:0070837 P:dehydroascorbic acid transport
GO:0046323 P:glucose import
GO:0043066 P:negative regulation of apoptosis
GO:0009749 P:response to glucose stimulus

References (2)

[1] “Neuron-specific glucose transporter (NSGT): CNS distribution of GLUT3 rat glucose transporter (RGT3) in rat central neurons.”  Nagamatsu S.et.al.   8243635
[2] “Cloning of glucose transporter-3 (GLUT3) cDNA from rat brain.”  Krishnan S.N.et.al.   7475896

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MGTAKVTPSL VFAVTVATIG SFQFGYNTGV INAPETIIKD FLNYTLEERL EDLPREGLLT 
61:	TLWSLCVAIF SVGGMIGSFS VGLFVNRFGR RNSMLLVNLI AILGGCLMGF AKIAESVEML 
121:	ILGRLIIGIF CGLCTGFVPM YIGEVSPTAL RGAFGTLNQL GIVVGILVAQ VFGLDFILGS 
181:	EELWPGLLGL TIIPAILQSA ALPFCPESPR FLLINRKEED QATEILQRLW GTPDVIQEIQ 
241:	EMKDESIRMS QEKQVTVLEL FKSPSYFQPL LISVVLQLSQ QFSGINAVFY YSTGIFQDAG 
301:	VQEPIYATIG AGVVNTIFTV VSLFLVERAG RRTLHMIGLG GMAVCSVFMT ISLLLKDEYE 
361:	AMSFVCIVAI LVYVAFFEIG PGPIPWFIVA ELFSQGPRPA AMAVAGCSNW TSNFLVGMFF 
421:	PSAAAYLGAY VFIIFAAFLV FFLIFTSFKV PETKGRTFED ITRAFEGQAH SGKGSAGVEL 
481:	NSMQPVKETP GNA