about | faq
TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.1.1.13
Fructose uniporter

Accession Number:P22732
Protein Name:Solute carrier family 2, facilitated glucose transporter member 5
Length:501
Molecular Weight:54974.00
Species: [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2

Cross database links:

Genevestigator: P22732
eggNOG: prNOG16095
HEGENOM: HBG744444
RefSeq: NP_003030.1   
Entrez Gene ID: 6518   
Pfam: PF00083   
OMIM: 138230  gene

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005353 F:fructose transmembrane transporter activity
GO:0005355 F:glucose transmembrane transporter activity
GO:0005975 P:carbohydrate metabolic process
GO:0015755 P:fructose transport
GO:0015758 P:glucose transport
GO:0055085 P:transmembrane transport

References (6)

[1] “Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6).”  Kayano T.et.al.   1695905
[2] “Regulation of expression of the human fructose transporter (GLUT5) by cyclic AMP.”  Mahraoui L.et.al.   8037665
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Cluster analysis of an extensive human breast cancer cell line protein expression map database.”  Harris R.A.et.al.   11840567
Structure:
1YG1     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MEQQDQSMKE GRLTLVLALA TLIAAFGSSF QYGYNVAAVN SPALLMQQFY NETYYGRTGE 
61:	FMEDFPLTLL WSVTVSMFPF GGFIGSLLVG PLVNKFGRKG ALLFNNIFSI VPAILMGCSR 
121:	VATSFELIII SRLLVGICAG VSSNVVPMYL GELAPKNLRG ALGVVPQLFI TVGILVAQIF 
181:	GLRNLLANVD GWPILLGLTG VPAALQLLLL PFFPESPRYL LIQKKDEAAA KKALQTLRGW 
241:	DSVDREVAEI RQEDEAEKAA GFISVLKLFR MRSLRWQLLS IIVLMGGQQL SGVNAIYYYA 
301:	DQIYLSAGVP EEHVQYVTAG TGAVNVVMTF CAVFVVELLG RRLLLLLGFS ICLIACCVLT 
361:	AALALQDTVS WMPYISIVCV ISYVIGHALG PSPIPALLIT EIFLQSSRPS AFMVGGSVHW 
421:	LSNFTVGLIF PFIQEGLGPY SFIVFAVICL LTTIYIFLIV PETKAKTFIE INQIFTKMNK 
481:	VSEVYPEKEE LKELPPVTSE Q