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2.A.1.1.14
Hexose:H+ symporter of 534 aas and 12 TMSs.  Substrate accumulation can be up to 1500-fold;  one proton  is symporter per hexose taken up. Helices I, V, VII and XI interact with the sugar during translocation and line the transport path through the membrane (Tanner 2000).

Accession Number:P15686
Protein Name:Hup1
Length:534
Molecular Weight:57523.00
Species:Chlorella kessleri [3074]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Hexoses

Cross database links:

Pfam: PF00083   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0022891 F:substrate-specific transmembrane transporte...
GO:0015293 F:symporter activity
GO:0008643 P:carbohydrate transport
GO:0055085 P:transmembrane transport

References (2)

[1] “The hexose carrier from Chlorella. cDNA cloning of a eucaryotic H+-cotransporter.”  Sauer N.et.al.   2599110
[2] “The Chlorella H+/hexose cotransporter gene.”  Wolf K.et.al.   1868571

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAGGGVVVVS GRGLSTGDYR GGLTVYVVMV AFMAACGGLL LGYDNGVTGG VVSLEAFEKK 
61:	FFPDVWAKKQ EVHEDSPYCT YDNAKLQLFV SSLFLAGLVS CLFASWITRN WGRKVTMGIG 
121:	GAFFVAGGLV NAFAQDMAML IVGRVLLGFG VGLGSQVVPQ YLSEVAPFSH RGMLNIGYQL 
181:	FVTIGILIAG LVNYAVRDWE NGWRLSLGPA AAPGAILFLG SLVLPESPNF LVEKGKTEKG 
241:	REVLQKLCGT SEVDAEFADI VAAVEIARPI TMRQSWASLF TRRYMPQLLT SFVIQFFQQF 
301:	TGINAIIFYV PVLFSSLGSA NSAALLNTVV VGAVNVGSTL IAVMFSDKFG RRFLLIEGGI 
361:	QCCLAMLTTG VVLAIEFAKY GTDPLPKAVA SGILAVICIF ISGFAWSWGP MGWLIPSEIF 
421:	TLETRPAGTA VAVVGNFLFS FVIGQAFVSM LCAMEYGVFL FFAGWLVIMV LCAIFLLPET 
481:	KGVPIERVQA LYARHWFWNR VMGPAAAEVI AEDEKRVAAA SAIIKEEELS KAMK