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2.A.1.1.18
Glucose/mannose/fructose transporter and high affinity sensor, Snf3p (regulates glucose transport via other systems).  Residues involved in ligand preference are similar to those involved in transport (Dietvorst et al. 2010).  Snf3p in Candida glabrata is essential for growth in low glucose media but not high glucose media, and plays a role in the induction of severall hexose transporters (Ng et al. 2015).

Accession Number:Q06222
Protein Name:Th2A aka THT2A
Length:529
Molecular Weight:57005.00
Species:Trypanosoma brucei brucei [5702]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate glucose, Mannose, fructose

Cross database links:

Pfam: PF00083   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0022891 F:substrate-specific transmembrane transporte...
GO:0008643 P:carbohydrate transport
GO:0055085 P:transmembrane transport

References (1)

[1] “Differential regulation of two distinct families of glucose transporter genes in Trypanosoma brucei.”  Bringaud F.et.al.   8423781

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTERRDNVSH APDAIEGPND GAHAEDTSPG FFSFENLGVA QVQVVGGTLN GFSIGFVAVY 
61:	ILLYEVATNC SLFKTTEACK AVGSYGCEWK DTEVCSWKKE CDSDSDGVNP CESLIGYSSL 
121:	YSGIFASAMI VGSMVGSIIA GKCITMFGLK KSFIIVGVMS VVASALNHIS VATNEFWVLC 
181:	AGRVLMGIGL GVVCVICPMY VNENAHPKLS KVDGVLFQVF ITFGIMLAAM LGLILDKTVN 
241:	YDNDPDMAGR FHGFCAVSSV LSVAMFLVGM FLRESTATFS QDDDGKADGG MDPNEYGWGQ 
301:	MLWPLFMGAV TAGTLQLTGI NAVMNYAPKI TENLGMDPSL GNFLVMAWNF VTSLVAIPLA 
361:	SRFTMRQMFI TCSFVASCMC LFLCGIPVFP GVAEEKVKNG VATTGIALFI AAFEFGVGSC 
421:	FFVLAQDLFP PSFRPKGSSF VVMMQFIFNI LINLLYPITT EAISGGATGD QDKGQAVVFI 
481:	LFGLIGLICF VLQFFYLYPY DANQDHENDH GTEPVERILS PVDVPTPRN