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2.A.1.1.19
Glucose transporter and low affinity sensor, Rgt2p (regulates glucose transport in conjunction with Snf3p)

Accession Number:Q12300
Protein Name:RGT2 aka Rgt2p aka YDL138W aka D2160
Length:763
Molecular Weight:83159.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate glucose

Cross database links:

Genevestigator: Q12300
eggNOG: fuNOG04879
HEGENOM: HBG744444
DIP: DIP-2865N
RefSeq: NP_010143.1   
Entrez Gene ID: 851417   
Pfam: PF00083   
KEGG: sce:YDL138W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005536 F:glucose binding
GO:0004872 F:receptor activity
GO:0022891 F:substrate-specific transmembrane transporte...
GO:0008643 P:carbohydrate transport
GO:0051594 P:detection of glucose
GO:0007165 P:signal transduction
GO:0055085 P:transmembrane transport

References (4)

[1] “Analysis of a 26,756 bp segment from the left arm of yeast chromosome IV.”  Woelfl S.et.al.   8972577
[2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.”  Jacq C.et.al.   9169867
[3] “Two glucose transporters in Saccharomyces cerevisiae are glucose sensors that generate a signal for induction of gene expression.”  Oezcan S.et.al.   8901598
[4] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MNDSQNCLRQ REENSHLNPG NDFGHHQGAE CTINHNNMPH RNAYTESTND TEAKSIVMCD 
61:	DPNAYQISYT NNEPAGDGAI ETTSILLSQP LPLRSNVMSV LVGIFVAVGG FLFGYDTGLI 
121:	NSITDMPYVK TYIAPNHSYF TTSQIAILVS FLSLGTFFGA LIAPYISDSY GRKPTIMFST 
181:	AVIFSIGNSL QVASGGLVLL IVGRVISGIG IGIISAVVPL YQAEAAQKNL RGAIISSYQW 
241:	AITIGLLVSS AVSQGTHSKN GPSSYRIPIG LQYVWSSILA VGMIFLPESP RYYVLKDELN 
301:	KAAKSLSFLR GLPIEDPRLL EELVEIKATY DYEASFGPST LLDCFKTSEN RPKQILRIFT 
361:	GIAIQAFQQA SGINFIFYYG VNFFNNTGVD NSYLVSFISY AVNVAFSIPG MYLVDRIGRR 
421:	PVLLAGGVIM AIANLVIAIV GVSEGKTVVA SKIMIAFICL FIAAFSATWG GVVWVVSAEL 
481:	YPLGVRSKCT AICAAANWLV NFTCALITPY IVDVGSHTSS MGPKIFFIWG GLNVVAVIVV 
541:	YFAVYETRGL TLEEIDELFR KAPNSVISSK WNKKIRKRCL AFPISQQIEM KTNIKNAGKL 
601:	DNNNSPIVQD DSHNIIDVDG FLENQIQSND HMIAADKGSG SLVNIIDTAP LTSTEFKPVE 
661:	HPPVNYVDLG NGLGLNTYNR GPPSIISDST DEFYEENDSS YYNNNTERNG ANSVNTYMAQ 
721:	LINSSSTTSN DTSFSPSHNS NARTSSNWTS DLASKHSQYT SPQ