TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.1.1.2
Arabinose (xylose; galactose):H+ symporter, AraE (low affinity high capacity) (Khlebnikov et al. 2001).

Accession Number:P0AE24
Protein Name:Arabinose-proton symporter AraE aka B2841
Length:472
Molecular Weight:51684.00
Species:Escherichia coli [83333]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate L-arabinose, D-xylose, D-galactose, Arabinose

Cross database links:

Genevestigator: P0AE24
EchoBASE: EB0054
EcoGene: EG10056
eggNOG: COG0477
HEGENOM: HBG744444
RefSeq: AP_003404.1    NP_417318.1   
Entrez Gene ID: 947341   
Pfam: PF00083   
BioCyc: EcoCyc:ARAE-MONOMER    ECOL168927:B2841-MONOMER   
KEGG: ecj:JW2809    eco:b2841   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0022891 F:substrate-specific transmembrane transporte...
GO:0015293 F:symporter activity
GO:0008643 P:carbohydrate transport
GO:0055085 P:transmembrane transport

References (6)

[1] “Mammalian and bacterial sugar transport proteins are homologous.”  Maiden M.C.J.et.al.   3543693
[2] “The cloning, DNA sequence, and overexpression of the gene araE coding for arabinose-proton symport in Escherichia coli K12.”  Maiden M.C.J.et.al.   2836407
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “The araE low affinity L-arabinose transport promoter. Cloning, sequence, transcription start site and DNA binding sites of regulatory proteins.”  Stoner C.et.al.   6319708
[6] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MVTINTESAL TPRSLRDTRR MNMFVSVAAA VAGLLFGLDI GVIAGALPFI TDHFVLTSRL 
61:	QEWVVSSMML GAAIGALFNG WLSFRLGRKY SLMAGAILFV LGSIGSAFAT SVEMLIAARV 
121:	VLGIAVGIAS YTAPLYLSEM ASENVRGKMI SMYQLMVTLG IVLAFLSDTA FSYSGNWRAM 
181:	LGVLALPAVL LIILVVFLPN SPRWLAEKGR HIEAEEVLRM LRDTSEKARE ELNEIRESLK 
241:	LKQGGWALFK INRNVRRAVF LGMLLQAMQQ FTGMNIIMYY APRIFKMAGF TTTEQQMIAT 
301:	LVVGLTFMFA TFIAVFTVDK AGRKPALKIG FSVMALGTLV LGYCLMQFDN GTASSGLSWL 
361:	SVGMTMMCIA GYAMSAAPVV WILCSEIQPL KCRDFGITCS TTTNWVSNMI IGATFLTLLD 
421:	SIGAAGTFWL YTALNIAFVG ITFWLIPETK NVTLEHIERK LMAGEKLRNI GV