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2.A.1.1.29
Glucosamine/glucose uniporter, Glut-2 (may also transport dehydroascorbate (Mardones et al., 2011Maulén et al., 2003), and cotransport water against an osmotic gradient (Naftalin, 2008))

Accession Number:P11168
Protein Name:Gtr2 aka Glut2 aka SLC2A2
Length:524
Molecular Weight:57490.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2

Cross database links:

Genevestigator: P11168 P11168
eggNOG: prNOG04098 COG0477
HEGENOM: HBG744444 HOG000202871
RefSeq: NP_000331.1   
Entrez Gene ID: 6514   
Pfam: PF00083   
Drugbank: Drugbank Link   
OMIM: 138160  gene
227810  phenotype
KEGG: hsa:6514    hsa:6514   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0005975 P:carbohydrate metabolic process
GO:0015758 P:glucose transport
GO:0055085 P:transmembrane transport
GO:0016323 C:basolateral plasma membrane
GO:0031526 C:brush border membrane
GO:0005829 C:cytosol
GO:0005768 C:endosome
GO:0055056 F:D-glucose transmembrane transporter activity
GO:0033300 F:dehydroascorbic acid transporter activity
GO:0005355 F:glucose transmembrane transporter activity
GO:0031018 P:endocrine pancreas development
GO:0006112 P:energy reserve metabolic process
GO:0015755 P:fructose transport
GO:0050796 P:regulation of insulin secretion
GO:0009749 P:response to glucose stimulus
GO:0043434 P:response to peptide hormone stimulus
GO:0044281 P:small molecule metabolic process

References (14)

[1] “Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein.”  Fukumoto H.et.al.   3399500
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “Sequence variations of the pancreatic islet/liver glucose transporter (GLUT2) gene in Japanese subjects with noninsulin dependent diabetes mellitus.”  Matsubara A.et.al.   7593414
[4] “Variability of the pancreatic islet beta cell/liver (GLUT 2) glucose transporter gene in NIDDM patients.”  Tanizawa Y.et.al.   8063045
[5] “A mutation in the Glut2 glucose transporter gene of a diabetic patient abolishes transport activity.”  Mueckler M.et.al.   8027028
[6] “A mutation in GLUT2, not in phosphorylase kinase subunits, in hepato-renal glycogenosis with Fanconi syndrome and low phosphorylase kinase activity.”  Burwinkel B.et.al.   10987651
[7] “Mutation analysis of the GLUT2 gene in patients with Fanconi-Bickel syndrome.”  Sakamoto O.et.al.   11044475
[8] “Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein.”  Fukumoto H.et.al.   3399500
[9] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[10] “Sequence variations of the pancreatic islet/liver glucose transporter (GLUT2) gene in Japanese subjects with noninsulin dependent diabetes mellitus.”  Matsubara A.et.al.   7593414
[11] “Variability of the pancreatic islet beta cell/liver (GLUT 2) glucose transporter gene in NIDDM patients.”  Tanizawa Y.et.al.   8063045
[12] “A mutation in the Glut2 glucose transporter gene of a diabetic patient abolishes transport activity.”  Mueckler M.et.al.   8027028
[13] “A mutation in GLUT2, not in phosphorylase kinase subunits, in hepato-renal glycogenosis with Fanconi syndrome and low phosphorylase kinase activity.”  Burwinkel B.et.al.   10987651
[14] “Mutation analysis of the GLUT2 gene in patients with Fanconi-Bickel syndrome.”  Sakamoto O.et.al.   11044475

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTEDKVTGTL VFTVITAVLG SFQFGYDIGV INAPQQVIIS HYRHVLGVPL DDRKAINNYV 
61:	INSTDELPTI SYSMNPKPTP WAEEETVAAA QLITMLWSLS VSSFAVGGMT ASFFGGWLGD 
121:	TLGRIKAMLV ANILSLVGAL LMGFSKLGPS HILIIAGRSI SGLYCGLISG LVPMYIGEIA 
181:	PTALRGALGT FHQLAIVTGI LISQIIGLEF ILGNYDLWHI LLGLSGVRAI LQSLLLFFCP 
241:	ESPRYLYIKL DEEVKAKQSL KRLRGYDDVT KDINEMRKER EEASSEQKVS IIQLFTNSSY 
301:	RQPILVALML HVAQQFSGIN GIFYYSTSIF QTAGISKPVY ATIGVGAVNM VFTAVSVFLV 
361:	EKAGRRSLFL IGMSGMFVCA IFMSVGLVLL NKFSWMSYVS MIAIFLFVSF FEIGPGPIPW 
421:	FMVAEFFSQG PRPAALAIAA FSNWTCNFIV ALCFQYIADF CGPYVFFLFA GVLLAFTLFT 
481:	FFKVPETKGK SFEEIAAEFQ KKSGSAHRPK AAVEMKFLGA TETV