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2.A.1.1.30
Low affinity, constitutive, glucose (hexose; xylose) uniporter, Hxt4 (LGT1) (also transports arsenic trioxide [As(OH)3] as do Hxtl, 3, 5, 7 and 9) (Liu et al., 2004)

Accession Number:P32467
Protein Name:Hxt4 aka LGT1 aka RAG1 aka YHR092C
Length:576
Molecular Weight:63910.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Xylose, glucose

Cross database links:

Genevestigator: P32467
eggNOG: fuNOG06406
HEGENOM: HBG744444
DIP: DIP-7908N
RefSeq: NP_011960.1   
Entrez Gene ID: 856492   
Pfam: PF00083   
KEGG: sce:YHR092C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005624 C:membrane fraction
GO:0005886 C:plasma membrane
GO:0005353 F:fructose transmembrane transporter activity
GO:0005355 F:glucose transmembrane transporter activity
GO:0015578 F:mannose transmembrane transporter activity
GO:0015146 F:pentose transmembrane transporter activity
GO:0008645 P:hexose transport
GO:0055085 P:transmembrane transport

References (5)

[1] “High-copy suppression of glucose transport defects by HXT4 and regulatory elements in the promoters of the HXT genes in Saccharomyces cerevisiae.”  Theodoris G.et.al.   7982576
[2] “Low-affinity glucose carrier gene LGT1 of Saccharomyces cerevisiae, a homologue of the Kluyveromyces lactis RAG1 gene.”  Prior C.et.al.   8154188
[3] “Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII.”  Johnston M.et.al.   8091229
[4] “A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery.”  Hitchcock A.L.et.al.   14557538
[5] “Xylose transport studies with xylose-utilizing Saccharomyces cerevisiae strains expressing heterologous and homologous permeases.”  Saloheimo A.et.al.   17180689

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSEEAAYQED TAVQNTPADA LSPVESDSNS ALSTPSNKAE RDDMKDFDEN HEESNNYVEI 
61:	PKKPASAYVT VSICCLMVAF GGFVFGWDTG TISGFVAQTD FIRRFGMKHH DGTYYLSKVR 
121:	TGLIVSIFNI GCAIGGIILA KLGDMYGRKM GLIVVVVIYI IGIIIQIASI NKWYQYFIGR 
181:	IISGLGVGGI AVLSPMLISE VSPKHIRGTL VSCYQLMITL GIFLGYCTNY GTKTYTNSVQ 
241:	WRVPLGLGFA WALFMIGGMT FVPESPRYLV EVGKIEEAKR SIALSNKVSA DDPAVMAEVE 
301:	VVQATVEAEK LAGNASWGEI FSTKTKVFQR LIMGAMIQSL QQLTGDNYFF YYGTTVFTAV 
361:	GLEDSFETSI VLGIVNFAST FVGIFLVERY GRRRCLLWGA ASMTACMVVF ASVGVTRLWP 
421:	NGKKNGSSKG AGNCMIVFTC FYLFCFATTW APIPFVVNSE TFPLRVKSKC MAIAQACNWI 
481:	WGFLIGFFTP FISGAIDFYY GYVFMGCLVF SYFYVFFFVP ETKGLTLEEV NTLWEEGVLP 
541:	WKSPSWVPPN KRGTDYNADD LMHDDQPFYK KMFGKK