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2.A.1.1.31
High affinity, glucose-repressible, glucose (hexose) uniporter (Hxt6/Hxt7). Asn331 and hydrophobic residue side chains in TMS5 determine substrate affinity (Kasahara et al., 2011; Kasahara and Kasahara 2010).  Also transports xylose (<Kasahara and Kasahara 2010).  Also transports xylose (Wang et al. 2013).

Accession Number:P39004
Protein Name:High-affinity hexose transporter HXT6
Length:570
Molecular Weight:62735.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Hexoses

Cross database links:

Genevestigator: P39004
eggNOG: fuNOG06406
HEGENOM: HBG744444
DIP: DIP-5182N
Entrez Gene ID: 851943   
Pfam: PF00083   
KEGG: sce:YDR342C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005739 C:mitochondrion
GO:0005886 C:plasma membrane
GO:0001950 C:plasma membrane enriched fraction
GO:0005353 F:fructose transmembrane transporter activity
GO:0005355 F:glucose transmembrane transporter activity
GO:0015578 F:mannose transmembrane transporter activity
GO:0015146 F:pentose transmembrane transporter activity

References (6)

[1] “Identification of novel HXT genes in Saccharomyces cerevisiae reveals the impact of individual hexose transporters on glycolytic flux.”  Reifenberger E.et.al.   7651133
[2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.”  Jacq C.et.al.   9169867
[3] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[4] “A proteomics approach to understanding protein ubiquitination.”  Peng J.et.al.   12872131
[5] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258
[6] “A multidimensional chromatography technology for in-depth phosphoproteome analysis.”  Albuquerque C.P.et.al.   18407956

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSQDAAIAEQ TPVEHLSAVD SASHSVLSTP SNKAERDEIK AYGEGEEHEP VVEIPKRPAS 
61:	AYVTVSIMCI MIAFGGFVFG WDTGTISGFI NQTDFIRRFG MKHKDGTNYL SKVRTGLIVS 
121:	IFNIGCAIGG IILSKLGDMY GRKVGLIVVV VIYIIGIIIQ IASINKWYQY FIGRIISGLG 
181:	VGGIAVLSPM LISEVSPKHL RGTLVSCYQL MITAGIFLGY CTNFGTKNYS NSVQWRVPLG 
241:	LCFAWALFMI GGMTFVPESP RYLAEVGKIE EAKRSIAVSN KVAVDDPSVL AEVEAVLAGV 
301:	EAEKLAGNAS WGELFSSKTK VLQRLIMGAM IQSLQQLTGD NYFFYYGTTI FKAVGLSDSF 
361:	ETSIVLGIVN FASTFVGIYV VERYGRRTCL LWGAASMTAC MVVYASVGVT RLWPNGQDQP 
421:	SSKGAGNCMI VFACFYIFCF ATTWAPIPYV VVSETFPLRV KSKAMSIATA ANWLWGFLIG 
481:	FFTPFITGAI NFYYGYVFMG CLVFMFFYVL LVVPETKGLT LEEVNTMWEE GVLPWKSASW 
541:	VPPSRRGANY DAEEMTHDDK PLYKRMFSTK