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2.A.1.1.34
The broad specificity sugar/sugar alcohol (myo-inositol, glycerol, ribose, sorbitol, mannitol, xylitol, erythritol, etc) H+ symporter, AtPLT5 (transports a wide range of hexoses, pentoses, tetroses, sugar alcohols and a sugar acid, but not disaccharides) (Reinders et al., 2005) (expressed in roots, leaves and floral organs) (Klepek et al., 2004)

Accession Number:Q8VZ80
Protein Name:AtPLT5
Length:539
Molecular Weight:58103.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate myo-inositol, glycerol, Ribose, Sorbitol, mannitol, Xylitol, Erythritol, H+

Cross database links:

Genevestigator: Q8VZ80
eggNOG: KOG0254
HEGENOM: HBG744444
RefSeq: NP_188513.1   
Entrez Gene ID: 821416   
Pfam: PF00083   
KEGG: ath:AT3G18830   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015591 F:D-ribose transmembrane transporter activity
GO:0015148 F:D-xylose transmembrane transporter activity
GO:0005354 F:galactose transmembrane transporter activity
GO:0005355 F:glucose transmembrane transporter activity
GO:0015168 F:glycerol transmembrane transporter activity
GO:0015575 F:mannitol transmembrane transporter activity
GO:0005365 F:myo-inositol transmembrane transporter acti...
GO:0015576 F:sorbitol transmembrane transporter activity
GO:0005351 F:sugar:hydrogen symporter activity
GO:0008643 P:carbohydrate transport
GO:0055085 P:transmembrane transport

References (5)

[1] “Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones.”  Sato S.et.al.   10819329
[2] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[3] “Analysis of transport activity of Arabidopsis sugar alcohol permease homolog AtPLT5.”  Reinders A.et.al.   15525644
[4] “Arabidopsis POLYOL TRANSPORTER5, a new member of the monosaccharide transporter-like superfamily, mediates H+-symport of numerous substrates, including myo-inositol, glycerol, and ribose.”  Klepek Y.-S.et.al.   15598803
[5] “The monosaccharide transporter gene family in land plants is ancient and shows differential subfamily expression and expansion across lineages.”  Johnson D.A.et.al.   16923188

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTGATPENRT APSPPPVKHV PESVLPAKPP KRNNYAFACA ILASMTSILL GYDIGVMSGA 
61:	MIYIKRDLKI NDLQIGILAG SLNIYSLIGS CAAGRTSDWI GRRYTIVLAG AIFFAGAILM 
121:	GLSPNYAFLM FGRFIAGIGV GYALMIAPVY TAEVSPASSR GFLNSFPEVF INAGIMLGYV 
181:	SNLAFSNLPL KVGWRLMLGI GAVPSVILAI GVLAMPESPR WLVMQGRLGD AKRVLDKTSD 
241:	SPTEATLRLE DIKHAAGIPA DCHDDVVQVS RRNSHGEGVW RELLIRPTPA VRRVMIAAIG 
301:	IHFFQQASGI DAVVLFSPRI FKTAGLKTDH QQLLATVAVG VVKTSFILVA TFLLDRIGRR 
361:	PLLLTSVGGM VLSLAALGTS LTIIDQSEKK VMWAVVVAIA TVMTYVATFS IGAGPITWVY 
421:	SSEIFPLRLR SQGSSMGVVV NRVTSGVISI SFLPMSKAMT TGGAFYLFGG IATVAWVFFY 
481:	TFLPETQGRM LEDMDELFSG FRWRDSKSKP KGNPEKTVPN PEVEIGSNKQ WKEGDTQSS