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2.A.1.1.37
The glucose/fructose facilitator, Glut7 (SLC2A7) (a single mutation, I314V, results in loss of fructose transport but retention of glucose transport (Manolescu et al., 2005)

Accession Number:Q6PXP3
Protein Name:Glut7
Length:512
Molecular Weight:55728.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Glucose, fructose

Cross database links:

Genevestigator: Q6PXP3 Q6PXP3
eggNOG: prNOG06788 COG0477
HEGENOM: HBG744444 HOG000202871
RefSeq: NP_997303.2   
Entrez Gene ID: 155184   
Pfam: PF00083   
OMIM: 610371  gene
KEGG: hsa:155184    hsa:155184   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005353 F:fructose transmembrane transporter activity
GO:0008643 P:carbohydrate transport
GO:0055085 P:transmembrane transport
GO:0005886 C:plasma membrane
GO:0022891 F:substrate-specific transmembrane transporter activity

References (4)

[1] “Cloning and functional characterization of the human GLUT7 isoform SLC2A7 from the small intestine.”  Li Q.et.al.   15033637
[2] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[3] “Cloning and functional characterization of the human GLUT7 isoform SLC2A7 from the small intestine.”  Li Q.et.al.   15033637
[4] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
Structure:
1YG7     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MENKEAGTPP PIPSREGRLQ PTLLLATLSA AFGSAFQYGY NLSVVNTPHK VFKSFYNETY 
61:	FERHATFMDG KLMLLLWSCT VSMFPLGGLL GSLLVGLLVD SCGRKGTLLI NNIFAIIPAI 
121:	LMGVSKVAKA FELIVFSRVV LGVCAGISYS ALPMYLGELA PKNLRGMVGT MTEVFVIVGV 
181:	FLAQIFSLQA ILGNPAGWPV LLALTGVPAL LQLLTLPFFP ESPRYSLIQK GDEATARQAL 
241:	RRLRGHTDME AELEDMRAEA RAERAEGHLS VLHLCALRSL RWQLLSIIVL MAGQQLSGIN 
301:	AINYYADTIY TSAGVEAAHS QYVTVGSGVV NIVMTITSAV LVERLGRRHL LLAGYGICGS 
361:	ACLVLTVVLL FQNRVPELSY LGIICVFAYI AGHSIGPSPV PSVVRTEIFL QSSRRAAFMV 
421:	DGAVHWLTNF IIGFLFPSIQ EAIGAYSFII FAGICLLTAI YIYVVIPETK GKTFVEINRI 
481:	FAKRNRVKLP EEKEETIDAG PPTASPAKET SF