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2.A.1.1.46
The blastocyst/testis glucose transporter, Glut8 (Doege et al., 2000) (insulin stimulated in blastocysts) (Carayannopoulos et al., 2000).

Accession Number:Q9JIF3
Protein Name:Solute carrier family 2, facilitated glucose transporter member 8 aka Glut8
Length:477
Molecular Weight:51524.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate glucose

Cross database links:

Genevestigator: Q9JIF3
HEGENOM: HBG744444
RefSeq: NP_062361.1   
Entrez Gene ID: 56017   
Pfam: PF00083   
KEGG: mmu:56017   

Gene Ontology

GO:0030659 C:cytoplasmic vesicle membrane
GO:0005887 C:integral to plasma membrane
GO:0005536 F:glucose binding
GO:0005355 F:glucose transmembrane transporter activity
GO:0006006 P:glucose metabolic process
GO:0015758 P:glucose transport
GO:0008286 P:insulin receptor signaling pathway
GO:0001666 P:response to hypoxia
GO:0055085 P:transmembrane transport

References (5)

[1] “GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues.”  Ibberson M.R.et.al.   10671487
[2] “GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity.”  Doege H.et.al.   10821868
[3] “GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocyst.”  Carayannopoulos M.O.et.al.   10860996
[4] “Mouse GLUT8: genomic organization and regulation of expression in 3T3-L1 adipocytes by glucose.”  Scheepers A.et.al.   11689004
[5] “Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the beta2-adaptin subunit of the AP-2 adaptor complex.”  Schmidt U.et.al.   16723738

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSPEDPQETQ PLLRPPEART PRGRRVFLAS FAAALGPLSF GFALGYSSPA IPSLRRTAPP 
61:	ALRLGDNAAS WFGAVVTLGA AAGGILGGWL LDRSGRKLSL LLCTVPFVTG FAVITAARDV 
121:	WMLLGGRLLT GLACGVASLV APVYISEIAY PAVRGLLGSC VQLMVVTGIL LAYVAGWVLE 
181:	WRWLAVLGCV PPTLMLLLMC YMPETPRFLL TQHQYQEAMA ALRFLWGSEE GWEEPPVGAE 
241:	HQGFQLALLR RPGIYKPLII GISLMVFQQL SGVNAIMFYA NSIFEEAKFK DSSLASVTVG 
301:	IIQVLFTAVA ALIMDRAGRR LLLALSGVIM VFSMSAFGTY FKLTQSLPSN SSHVGLVPIA 
361:	AEPVDVQVGL AWLAVGSMCL FIAGFAVGWG PIPWLLMSEI FPLHVKGVAT GICVLTNWFM 
421:	AFLVTKEFSS VMEMLRPYGA FWLTAAFCAL SVLFTLTVVP ETKGRTLEQV TAHFEGR