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2.A.1.1.47
The embryonic liver, kidney, and other tissue uric acid (urate) transporter, Glut9 (SLC2A9) (Wright et al. 2010). Mutations in this transporter cause severe renal hyperuricemia.  It transports hexoses as well as urate, the latter by an electrogenic uniport mechanism.  It's transcription is regulated by a hepatocyte nuclear factor, HNF4α (Prestin et al. 2014).

Accession Number:Q5ERC7
Protein Name:Glucose transporter 9b aka Glut9
Length:523
Molecular Weight:57044.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Urate

Cross database links:

Genevestigator: Q5ERC7
RefSeq: NP_001012363.2   
Entrez Gene ID: 117591   
Pfam: PF00083   
KEGG: mmu:117591   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005635 C:nuclear envelope
GO:0005355 F:glucose transmembrane transporter activity
GO:0015758 P:glucose transport
GO:0055085 P:transmembrane transport

References (1)

[1] “Mouse glucose transporter 9 splice variants are expressed in adult liver and kidney and are up-regulated in diabetes.”  Keembiyehetty C.et.al.   16293642

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKLSEKNSAE TKESQRKWSF SLVVAALVGA FGSSFLYGYN LSVVNAPTPY IKAFYNGTWY 
61:	RRHGQPIDPD TLTLLWSVTV SIFAIGGLVG TLMVKMIGKF LGRKSTLLVN NGFAISAALL 
121:	MACSLRAGTF EMLIVGRFIM GVDGGIALSA LPMYLNEISP KEIRGSLGQV TAIFICIGVF 
181:	SGQLLGLPEL LGRESTWPYL FGVIIVPALV QLASLPFLPE SPRYLLFEKH DEAGAMKAFQ 
241:	TFLGKADVSQ ELEEALAESR VQRNLRLVSV LELLRAPFVR WQVITVIITM ASYQLCGLNA 
301:	IWFYTNSIFG KAGIPQDKIP YITLSTGGIE TLAAIFSGLV IERLGRGPLL IGGFGLMALF 
361:	FGTLTATLTL QDQAPWVPYL SIVCILAIIA SFCSGPGGIP FILTGEFFQQ SERPAAFMIA 
421:	GTVNWLSNFA VGLLFPFIQK SLDSYCFLVF ATICIAGATY FYFVLPETKN RTHAEISQAF 
481:	AKRNKAQPPE VKADSAMTEE KANSQTEPDS SSTLDSYGQN KIV