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2.A.1.1.59
The glucose transporter, GLUT10, was originally believed to be responsible for Type 2 diabetes. It is now believed to be responsible for arterial tortuosity, a rare autosomal recessive connective tissue disease (Callewaert et al., 2007). GLUT10 transports glucose and 2-deoxy glucose (Km=0.3 mM), and is inhibited by galactose and phloretin (Coucke et al., 2006).

Accession Number:O95528
Protein Name:Glucose transporter type 10 aka GLUT10
Length:541
Molecular Weight:56911.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Endomembrane system1 / Multi-pass membrane protein2
Substrate glucose, 2-deoxyglucose

Cross database links:

Genevestigator: O95528 O95528
eggNOG: prNOG11533 COG0477
HEGENOM: HBG744444 HOG000202868
RefSeq: NP_110404.1   
Entrez Gene ID: 81031   
Pfam: PF00083   
OMIM: 208050  phenotype
606145  gene
KEGG: hsa:81031    hsa:81031   

Gene Ontology

GO:0012505 C:endomembrane system
GO:0016021 C:integral to membrane
GO:0048471 C:perinuclear region of cytoplasm
GO:0005351 F:sugar:hydrogen symporter activity
GO:0015758 P:glucose transport
GO:0055085 P:transmembrane transport
GO:0005886 C:plasma membrane

References (16)

[1] “Molecular cloning of a novel member of the GLUT family of transporters, SLC2A10 (GLUT10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility.”  McVie-Wylie A.J.et.al.   11247674
[2] “Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1.”  Dawson P.A.et.al.   11592815
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The DNA sequence and comparative analysis of human chromosome 20.”  Deloukas P.et.al.   11780052
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary traits.”  Andersen G.et.al.   12941788
[7] “Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome.”  Coucke P.J.et.al.   16550171
[8] “Arterial tortuosity syndrome: clinical and molecular findings in 12 newly identified families.”  Callewaert B.L.et.al.   17935213
[9] “Molecular cloning of a novel member of the GLUT family of transporters, SLC2A10 (GLUT10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility.”  McVie-Wylie A.J.et.al.   11247674
[10] “Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1.”  Dawson P.A.et.al.   11592815
[11] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[12] “The DNA sequence and comparative analysis of human chromosome 20.”  Deloukas P.et.al.   11780052
[13] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[14] “Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary traits.”  Andersen G.et.al.   12941788
[15] “Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome.”  Coucke P.J.et.al.   16550171
[16] “Arterial tortuosity syndrome: clinical and molecular findings in 12 newly identified families.”  Callewaert B.L.et.al.   17935213

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FASTA formatted sequence
1:	MGHSPPVLPL CASVSLLGGL TFGYELAVIS GALLPLQLDF GLSCLEQEFL VGSLLLGALL 
61:	ASLVGGFLID CYGRKQAILG SNLVLLAGSL TLGLAGSLAW LVLGRAVVGF AISLSSMACC 
121:	IYVSELVGPR QRGVLVSLYE AGITVGILLS YALNYALAGT PWGWRHMFGW ATAPAVLQSL 
181:	SLLFLPAGTD ETATHKDLIP LQGGEAPKLG PGRPRYSFLD LFRARDNMRG RTTVGLGLVL 
241:	FQQLTGQPNV LCYASTIFSS VGFHGGSSAV LASVGLGAVK VAATLTAMGL VDRAGRRALL 
301:	LAGCALMALS VSGIGLVSFA VPMDSGPSCL AVPNATGQTG LPGDSGLLQD SSLPPIPRTN 
361:	EDQREPILST AKKTKPHPRS GDPSAPPRLA LSSALPGPPL PARGHALLRW TALLCLMVFV 
421:	SAFSFGFGPV TWLVLSEIYP VEIRGRAFAF CNSFNWAANL FISLSFLDLI GTIGLSWTFL 
481:	LYGLTAVLGL GFIYLFVPET KGQSLAEIDQ QFQKRRFTLS FGHRQNSTGI PYSRIEISAA 
541:	S