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2.A.1.1.6
Galactose, glucose uniporter, Gal2. Also transports xylose (Wang et al. 2013).  This transporter has been engineered by mutation (N376F) to transport xylose without being inhibited by glucose or transporting other hexoses (Farwick et al. 2014).  The 3-d structure is known (Wang et al. 2015).

Accession Number:P13181
Protein Name:Gal2 aka IMP1 aka YLR081W aka L9449.6
Length:574
Molecular Weight:63626.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Galactose, glucose, Xylose

Cross database links:

Genevestigator: P13181
eggNOG: fuNOG06406
HEGENOM: HBG744444
DIP: DIP-4773N
RefSeq: NP_013182.1   
Entrez Gene ID: 850770   
Pfam: PF00083   
KEGG: sce:YLR081W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005354 F:galactose transmembrane transporter activity
GO:0005355 F:glucose transmembrane transporter activity
GO:0006012 P:galactose metabolic process
GO:0015757 P:galactose transport
GO:0055085 P:transmembrane transport

References (4)

[1] “Sequence and structure of the yeast galactose transporter.”  Szkutnicka K.et.al.   2666404
[2] “Yeast galactose permease is related to yeast and mammalian glucose transporters.”  Nehlin J.O.et.al.   2697639
[3] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.”  Johnston M.et.al.   9169871
[4] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAVEENNMPV VSQQPQAGED VISSLSKDSH LSAQSQKYSN DELKAGESGS EGSQSVPIEI 
61:	PKKPMSEYVT VSLLCLCVAF GGFMFGWDTG TISGFVVQTD FLRRFGMKHK DGTHYLSNVR 
121:	TGLIVAIFNI GCAFGGIILS KGGDMYGRKK GLSIVVSVYI VGIIIQIASI NKWYQYFIGR 
181:	IISGLGVGGI AVLCPMLISE IAPKHLRGTL VSCYQLMITA GIFLGYCTNY GTKSYSNSVQ 
241:	WRVPLGLCFA WSLFMIGALT LVPESPRYLC EVNKVEDAKR SIAKSNKVSP EDPAVQAELD 
301:	LIMAGIEAEK LAGNASWGEL FSTKTKVFQR LLMGVFVQMF QQLTGNNYFF YYGTVIFKSV 
361:	GLDDSFETSI VIGVVNFAST FFSLWTVENL GHRKCLLLGA ATMMACMVIY ASVGVTRLYP 
421:	HGKSQPSSKG AGNCMIVFTC FYIFCYATTW APVAWVITAE SFPLRVKSKC MALASASNWV 
481:	WGFLIAFFTP FITSAINFYY GYVFMGCLVA MFFYVFFFVP ETKGLSLEEI QELWEEGVLP 
541:	WKSEGWIPSS RRGNNYDLED LQHDDKPWYK AMLE