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2.A.1.1.60
The major hexose transporter, Htr1 (mediates the active uptake of hexoses by sugar:H+ symport. Can transport glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose. Confers sensitivity to galactose in seedlings. Km=20 uM for glucose) (Stadler et al., 2003; Boorer et al., 1994)

Accession Number:P23586
Protein Name:Sugar transport protein 1 aka Htr1
Length:522
Molecular Weight:57611.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Hexoses

Cross database links:

Genevestigator: P23586
eggNOG: KOG0254
HEGENOM: HBG744444
RefSeq: NP_172592.1   
Entrez Gene ID: 837667   
Pfam: PF00083   
KEGG: ath:AT1G11260   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005634 C:nucleus
GO:0005886 C:plasma membrane
GO:0005773 C:vacuole
GO:0022891 F:substrate-specific transmembrane transporte...
GO:0015293 F:symporter activity
GO:0008643 P:carbohydrate transport
GO:0055085 P:transmembrane transport

References (14)

[1] “Primary structure, genomic organization and heterologous expression of a glucose transporter from Arabidopsis thaliana.”  Sauer N.et.al.   2209537
[2] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.”  Theologis A.et.al.   11130712
[3] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[4] “Functional expression of a plant plasma membrane transporter in Xenopus oocytes.”  Boorer K.J.et.al.   1633849
[5] “Steady-state and presteady-state kinetics of the H(+)/hexose cotransporter (STP1) from Arabidopsis thaliana expressed in Xenopus oocytes.”  Boorer K.J.et.al.   8051137
[6] “Functional reconstitution of the solubilized Arabidopsis thaliana STP1 monosaccharide-H(+) symporter in lipid vesicles and purification of the histidine tagged protein from transgenic Saccharomyces cerevisiae.”  Stolz J.et.al.   7920712
[7] “Monosaccharide/proton symporter AtSTP1 plays a major role in uptake and response of Arabidopsis seeds and seedlings to sugars.”  Sherson S.M.et.al.   11135118
[8] “Roles of cell-wall invertases and monosaccharide transporters in the growth and development of Arabidopsis.”  Sherson S.M.et.al.   12508063
[9] “Diurnal and light-regulated expression of AtSTP1 in guard cells of Arabidopsis.”  Stadler R.et.al.   12972665
[10] “Phosphoproteomics of the Arabidopsis plasma membrane and a new phosphorylation site database.”  Nuehse T.S.et.al.   15308754
[11] “The monosaccharide transporter gene family in land plants is ancient and shows differential subfamily expression and expansion across lineages.”  Johnson D.A.et.al.   16923188
[12] “Novel subsets of the Arabidopsis plasmalemma phosphoproteome identify phosphorylation sites in secondary active transporters.”  Hem S.et.al.   17869214
[13] “Site-specific phosphorylation profiling of Arabidopsis proteins by mass spectrometry and peptide chip analysis.”  de la Fuente van Bentem S.et.al.   18433157
[14] “Phosphoproteomic analysis of nuclei-enriched fractions from Arabidopsis thaliana.”  Jones A.M.E.et.al.   19245862

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPAGGFVVGD GQKAYPGKLT PFVLFTCVVA AMGGLIFGYD IGISGGVTSM PSFLKRFFPS 
61:	VYRKQQEDAS TNQYCQYDSP TLTMFTSSLY LAALISSLVA STVTRKFGRR LSMLFGGILF 
121:	CAGALINGFA KHVWMLIVGR ILLGFGIGFA NQAVPLYLSE MAPYKYRGAL NIGFQLSITI 
181:	GILVAEVLNY FFAKIKGGWG WRLSLGGAVV PALIITIGSL VLPDTPNSMI ERGQHEEAKT 
241:	KLRRIRGVDD VSQEFDDLVA ASKESQSIEH PWRNLLRRKY RPHLTMAVMI PFFQQLTGIN 
301:	VIMFYAPVLF NTIGFTTDAS LMSAVVTGSV NVAATLVSIY GVDRWGRRFL FLEGGTQMLI 
361:	CQAVVAACIG AKFGVDGTPG ELPKWYAIVV VTFICIYVAG FAWSWGPLGW LVPSEIFPLE 
421:	IRSAAQSITV SVNMIFTFII AQIFLTMLCH LKFGLFLVFA FFVVVMSIFV YIFLPETKGI 
481:	PIEEMGQVWR SHWYWSRFVE DGEYGNALEM GKNSNQAGTK HV