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2.A.1.1.62
High affinity (0.24mM) plasma membrane myoinositol-specific H+ symporter, INT4 (Schneider et al., 2006)

Accession Number:O23492
Protein Name:INT4
Length:582
Molecular Weight:62892.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate myo-inositol

Cross database links:

Genevestigator: O23492
eggNOG: KOG0254
HEGENOM: HBG744444
RefSeq: NP_193381.1   
Entrez Gene ID: 827346   
Pfam: PF00083   
KEGG: ath:AT4G16480   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005366 F:myo-inositol:hydrogen symporter activity
GO:0055085 P:transmembrane transport

References (5)

[1] “Arabidopsis INOSITOL TRANSPORTER4 mediates high-affinity H+ symport of myoinositol across the plasma membrane.”  Schneider S.et.al.   16603666
[2] “Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis thaliana.”  Bevan M.et.al.   9461215
[3] “Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.”  Mayer K.F.X.et.al.   10617198
[4] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[5] “The monosaccharide transporter gene family in land plants is ancient and shows differential subfamily expression and expansion across lineages.”  Johnson D.A.et.al.   16923188

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVEGGIAKAD KTEFTECWRT TWKTPYIMRL ALSAGIGGLL FGYDTGVISG ALLFIKEDFD 
61:	EVDKKTWLQS TIVSMAVAGA IVGAAVGGWI NDKFGRRMSI LIADVLFLIG AIVMAFAPAP 
121:	WVIIVGRIFV GFGVGMASMT SPLYISEASP ARIRGALVST NGLLITGGQF FSYLINLAFV 
181:	HTPGTWRWML GVAGVPAIVQ FVLMLSLPES PRWLYRKDRI AESRAILERI YPADEVEAEM 
241:	EALKLSVEAE KADEAIIGDS FSAKLKGAFG NPVVRRGLAA GITVQVAQQF VGINTVMYYS 
301:	PSIVQFAGYA SNKTAMALSL ITSGLNALGS IVSMMFVDRY GRRKLMIISM FGIIACLIIL 
361:	ATVFSQAAIH APKIDAFESR TFAPNATCSA YAPLAAENAP PSRWNCMKCL RSECGFCASG 
421:	VQPYAPGACV VLSDDMKATC SSRGRTFFKD GCPSKFGFLA IVFLGLYIVV YAPGMGTVPW 
481:	IVNSEIYPLR YRGLGGGIAA VSNWVSNLIV SESFLSLTHA LGSSGTFLLF AGFSTIGLFF 
541:	IWLLVPETKG LQFEEVEKLL EVGFKPSLLR RREKKGKEVD AA