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2.A.1.1.66
The tonoplast H+:Inositol symporter 1, Int1 (mediates efflux from the tonoplast to the cytoplasm (Schneider et al., 2008) (most similar to 2.A.1.1.63 and 2.A.1.1.62).

Accession Number:Q8VZR6
Protein Name:Int1
Length:509
Molecular Weight:54813.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate myo-inositol

Cross database links:

Genevestigator: Q8VZR6
eggNOG: KOG0254
HEGENOM: HBG744444
RefSeq: NP_850393.1   
Entrez Gene ID: 818934   
Pfam: PF00083   
KEGG: ath:AT2G43330   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0009705 C:plant-type vacuole membrane
GO:0005366 F:myo-inositol:hydrogen symporter activity
GO:0015798 P:myo-inositol transport
GO:0055085 P:transmembrane transport

References (4)

[1] “Arabidopsis INOSITOL TRANSPORTER4 mediates high-affinity H+ symport of myoinositol across the plasma membrane.”  Schneider S.et.al.   16603666
[2] “Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.”  Lin X.et.al.   10617197
[3] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[4] “The monosaccharide transporter gene family in land plants is ancient and shows differential subfamily expression and expansion across lineages.”  Johnson D.A.et.al.   16923188

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTLTIPNAPG SSGYLDMFPE RRMSYFGNSY ILGLTVTAGI GGLLFGYDTG VISGALLYIK 
61:	DDFEVVKQSS FLQETIVSMA LVGAMIGAAA GGWINDYYGR KKATLFADVV FAAGAIVMAA 
121:	APDPYVLISG RLLVGLGVGV ASVTAPVYIA EASPSEVRGG LVSTNVLMIT GGQFLSYLVN 
181:	SAFTQVPGTW RWMLGVSGVP AVIQFILMLF MPESPRWLFM KNRKAEAIQV LARTYDISRL 
241:	EDEIDHLSAA EEEEKQRKRT VGYLDVFRSK ELRLAFLAGA GLQAFQQFTG INTVMYYSPT 
301:	IVQMAGFHSN QLALFLSLIV AAMNAAGTVV GIYFIDHCGR KKLALSSLFG VIISLLILSV 
361:	SFFKQSETSS DGGLYGWLAV LGLALYIVFF APGMGPVPWT VNSEIYPQQY RGICGGMSAT 
421:	VNWISNLIVA QTFLTIAEAA GTGMTFLILA GIAVLAVIFV IVFVPETQGL TFSEVEQIWK 
481:	ERAYGNISGW GSSSDSNNME GLLEQGSQS