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2.A.1.1.76
Glucose transporter, GT1. GT1, 2, and 3 are homologues. GT2 and GT3 transport ribose as well as glucose at different rates. GT3 transports ribose with 6-fold lower efficiency due to two threonines in GT3 that are alanines in GT2. They are in two loops between TMSs 3, 4, and 7, 8 (Naula et al., 2010). GT1 is expressed in the flagellar membrane and may be both a glucose transporter and sensor, allowing the parasites to enter the stationary phase when they deplete glucose although in the absence of the sensor, they lose viability (Rodriguez-Contreras et al. 2015).

Accession Number:O76486
Protein Name:Glucose transporter
Length:610
Molecular Weight:66107.00
Species:Leishmania mexicana [5665]
Number of TMSs:12
Substrate glucose

Cross database links:

Pfam: PF00083   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0022891 F:substrate-specific transmembrane transporter activity
GO:0008643 P:carbohydrate transport

References (1)

[1] “Differential regulation of multiple glucose transporter genes in Leishmania mexicana.”  Burchmore R.J.et.al.   9786920

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLPPPQIPQP LKPKKVKLPH TSHAASSFQP SKRHLTPLPL QESKYISEKV PNPMKPPIAD 
61:	GIDEFVEESI SPNKELSPSF FSISNFRMIM VQAIGGCLNG YSIGFVGVYS TLFGYSTNCA 
121:	NFRSERGCTT APNADCQWFA NATGTSYCGW PEITCRRTYT YSSVAEMPGA IAQCEADSRC 
181:	RWSYSAKECQ NPSGYSSSES GIFAGSMIAG CLIGSVFAGP LASTIGARLS FLLVGLVGVV 
241:	SSVMCHVSAS ENEFWVLVVG RFVIGLFVGV IGVACPVYTD QNAHPKWKRT IGVMFQVFTT 
301:	LGIFIAAAVG LALGQSTYFD RNKDQMVMAR MQGLCAFSTL FSLLTILLGI VMSESRAKFG 
361:	GDDEEGGIEL DPNEYSYVEM VPRLLMGAVM AGTLQLTGIN AVMNYAPAIM GSLGLAPLVG 
421:	NFVVMLWNFV TTLASIPLSY VFTMRQLFLF GSLFTSSMCL FMCGIPVYPG VSKKTEVKNG 
481:	VAITGILLFI LGFEVCVGPC YYVLTQDMFP LSFRPRGASF TQVAQFIFNL IINVCYPIAT 
541:	EHISGGPSGN QDKGQAVAFI FFGCVGMICF IIQVFFLHPW DEKRDGKKRP ATPAGGKREL 
601:	SSSLSGNRAE