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2.A.1.1.78
The glucose transporter, LmGT3 (homologous to LmGT2 (1.A.1.1.75)). Two threonine residues located in the hydrophilic loops connecting TMSs 3 & 4 and 7 & 8 of GT3 prevent transport of D-ribose. Changing these two residues to alanine (as in GT2) allows transport of ribose. Thus, loops 3-4 and 7-8 partially determine substrate specificity (Naula et al., 2010).

Accession Number:O61060
Protein Name:Glucose transporter
Length:566
Molecular Weight:61250.00
Species:Leishmania mexicana [5665]
Number of TMSs:12
Substrate glucose

Cross database links:

Pfam: PF00083   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0022891 F:substrate-specific transmembrane transporter activity
GO:0008643 P:carbohydrate transport

References (4)

[1] “Differential regulation of multiple glucose transporter genes in Leishmania mexicana.”  Burchmore R.J.et.al.   9786920
[2] “A glucose transporter can mediate ribose uptake: definition of residues that confer substrate specificity in a sugar transporter.”  Naula C.M.et.al.   20601430
[3] “Differential regulation of multiple glucose transporter genes in Leishmania mexicana.”  Burchmore R.J.et.al.   9786920
[4] “A glucose transporter can mediate ribose uptake: definition of residues that confer substrate specificity in a sugar transporter.”  Naula C.M.et.al.   20601430

External Searches:

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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSDKLEANVQ SSNWLSEEPA RPDANKLGDE DDSPPFFSMS NVRVAMVQAI GGCLNGYSIG 
61:	FVGVYSTLFG YSTNCANFRS ERGCTTAPNA DCQWFANATG TSYCGWPEIT CRRTYTYSSV 
121:	AEMPGAIAQC EADSRCRWSY SAEECQNPSG YSSSESGIFA GSMIAGCLIG SVFAGPLAST 
181:	IGARLSFLLV GLVGVVSSVM YHVSTGENEF WVLVVGRFVI GLFVGVIGVA CPVYTDQNAH 
241:	PKWKRTIGVM FQVFTTLGIF IAAAVGLALG QSTYFDRNKD QMVMARMQGL CAFSTLFSLL 
301:	TILLGIVMSE SRAKFGGDDE EGGIELDPNE YSYVEMVPRL LMGAVMAGTL QLTGINAVMN 
361:	YAPTIMGSLG LAPLVGNFVV MLWNFVTTLA SIPLSYVFTM RQLFLFGSLF TSSMCLFMCG 
421:	IPVYPGVSKK TEVKNGVAIT GILLFILGFE VCVGPCYYVL TQDMFPLSFR PRGASLTQVT 
481:	QFLFNLVINV CYPIATEHIS GGLSGNQDKG QAVAFIFFGC VGMICFIIQV FFLHPWDEKR 
541:	DGKKRPATPA GGKRELSGEF VGKKEV